Dr Fauci in the ⁦@WhiteHouse⁩ briefing room
Fauci: If you look at the 7-day avg of cases, right now it looks like it may be plateauing.

But you have to be careful it’s not an artifact of slowing down after the holidays.

“I’m sort of getting deja vu standing up here. I said something like this almost a year ago.”
Fauci: There are always lags so please be aware of that - cases, weeks later hospitalizations, weeks later deaths.

Cases may be plateauing or coming down at the same time hospitalizations and deaths are going up.
Fauci on mutants: RNA viruses like coronaviruses mutate all the time. Most of the mutations don’t have any physiological relevant wrt the function of the virus itself.

Once in awhile you get mutations which do have an impact. What have we learned thus far?
Fauci: At least from experience UK has had, twice as much transmissibility as wild-type original virus.

They say on a 1-1 basis it doesn’t have a greater chance of making you seriously ill or killing you.

We shouldn’t be lulled into complacency about that.
Fauci: We’re seeing in the much more concerning mutations in South Africa and Brazil that it’s having an effect on monoclonal antibodies.

What is the impact on the vaccine?
Fauci: So far literally pre-prints - not peer-reviewed - saying what we likely will be seeing is a diminution, more from South Africa than UK variant, in what would be effect you in vaccine-induced antibodies.
Fauci: That does not mean that the vaccines will not be effective. There’s a thing called a cushion effect. Moderna and Pfizer vaccine that can suppress virus at dilution of 1:1000 and the mutant influences it by bringing it down to 1:800 you’re still well above the line.
Fauci: Thus far it does not appear the South African strain is in the US. But level of sequencing surveillance thus far is not at the level we would have liked. Given the information we have today it doesn’t appear the South African strain is here.
Fauci on difference btw administrations: There were things that were said, ie hydroxychloroquine, that were not based on fact. It was really something you didn’t feel you could actually say something and there wouldn’t be repercussions. (Cont)
Fauci: The idea that you can get up here and let the science speak, it is somewhat of a liberating feeling.

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More from @megtirrell

21 Jan
Exactly one year ago today, @CDCgov confirmed the first case of 2019-nCoV in the U.S.

24M cases later, what are the most important lessons learned, about the virus itself & our response?

10 experts shared their thoughts. A few in a 🧵next: cnbc.com/2021/01/21/cov…
.@DrPaulOffit:

“It is not the winter respiratory virus it was billed to be; it’s far more far-reaching and damaging than that.”
.@CarlosdelRio7:

"More airborne than we originally thought, less surface than we originally thought."

(Remember Clorox-wiping your groceries?)
Read 11 tweets
21 Jan
Biden signing 10 executive orders and other directives today on #covid19. Here they are per @WhiteHouse fact-sheet: 🧵

1. EO directing agencies to fix supply of PPE, materials for testing & vaccines, including through Defense Production Act
2. Presidential Memo directing FEMA to increase federal reimbursement to 100% (from 75%) of cost of National Guard personnel & emergency supplies; restoring full reimbursement for eligible costs to support safe school reopening through FEMA Disaster Relief Fund
3. EO to establish Pandemic Testing Board; increase testing capacity by directing use of Defense Production Act; promote surge capacity of testing in the US; onshore test manufacturing, expand public health workforce, support #covid19 screening for schools;ensure equitable access
Read 10 tweets
19 Jan
I enjoy the "Mean Girls" parallel of the title of this HBR session about to start: "When Dr Fauci Thinks 'Normal' Will Happen" linkedin.com/video/live/urn…
HBR host notes Dr Fauci got his second dose of Moderna vaccine today
Fauci: If we can get 75-80% of the population of this country fully vaccinated over a period of several months, we will have an umbrella or cloak of herd immunity that would completely turn around the dynamics of the outbreak.
Read 17 tweets
16 Jan
Still confused about the 2nd dose vaccine supply? Me too, but I think this is what happened: 🧵

Let’s go chronologically. Last Thursday, governors wrote a letter to @SecAzar requesting second doses not be held in reserve and instead immediately be made available:
2. Friday, CNN reported the Biden team planned to do just that:
3. Tuesday @SecAzar said OWS would make the change as well.

Azar: "We can now ship all of the doses, that had been held in physical reserve with second doses being supplied by doses coming off of manufacturing lines with quality control going forward."

Read 18 tweets
7 Jan
.@NYGovCuomo : "If the UK spread catches on in NY, hospitalization rate goes up, hospital staff gets sick - then we have a real problem. Then we're at shutdown again."

The problem with capacity now is staff shortage, he says. "We have beds, we have equipment." Primarily nurses.
Cuomo: Very worried about UK strain. Still just 1 case confirmed in NY, but believe we have more. Notes spread in UK only took about 3 weeks.

Says this concern + staff shortages at hospitals is why such a push for faster vaccination of health-care workers.
Cuomo: "We have seen a dramatic increase" in performance of vaccinations.

Were doing 10k per day for first several wks

On Monday, went to 30k

Tuesday, a little over 30k

Wednesday, went to 50k

And today going to be in excess of 50k

"That's 5 times the rate they were doing."
Read 11 tweets
6 Jan
J&J’s CEO, Alex Gorsky, on events in Washington: Image
.@steveubl of @PhRMA on events in Washington: Image
Pfizer CEO @AlbertBourla letter to employees on events in Washington: Image
Read 4 tweets

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