1/ The Denmark variant story was pointed out by several people as being quite concerning- this line struck me - "Cases involving the variant are increasing 70 percent a week in Denmark, despite a strict lockdown"

But the actual data was hard to pin down- so I dug it up
2/ "The U.K. variant was 2 percent of sequenced coronavirus cases the last full week of 2020. By the second week of January, it had risen to 7 percent."

But in the context of declining cases what does that mean?

No link to data in article but it's here: covid19genomics.dk/statistics
3/ But those aren't actually the true cases, cause despite the headline "Denmark is sequencing all coronavirus samples..." while they are *trying* to sequence all, the number of cases with a genome of sufficient quality relative to the total number of cases ranges w-w from 10-36%
4/ In other words you need cases/week, variant rate and proportion tested to estimate the weekly number of the new variant in Denmark and understand how fast the variant is spreading.

This is what it looks like (yes, error bars had finite population adjustment, epi geeks)
5/ That looks .... a lot better in recent weeks.

It looks like it hasn't doubled in past month.

For context, here's what doubling time has looked like in different countries over time

The bottom-most line is doubling every month
6/ So, yes, a great explanation of exponential growth, but it appears that Denmark's restrictions have had a strong impact despite the new variant.

the initial spurt was certainly super concerning, but remember also that this outbreak is defined by lumpy super-spreader events
7/ The actual data from Denmark suggests a LOWER increase in infectiousness than original UK data, as
@trvrb has pointed out

Yes, it's a race between the variant and the vaccine, but we can't let ourselves get freaked out folks. What we knew worked before, still works

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More from @Farzad_MD

11 Jan
1/ read this @adamcancryn @tylerpager piece, and let's discuss some of the points raised

‘There is a palpable concern’: Biden presses advisers over 100 million Covid shot goal politi.co/2XHhk1f
2/ first, I am so glad @JoeBiden *is* putting a hard to reach goal out there

When @matkendall and I set our first public targets
@ONC_HealthIT a longtime fed told us "never give them a date AND a number"

It's risky, it's gutsy, and it's the right thing to do for the country.
3/ It will be very hard to hit 100M in 100 days

But the very fact that this article was written EVEN BEFORE THEY START points to the intense focus it brings.

The new admin may miss their first big test, but vaccinate tens of millions more than if they shunned responsibility

🇺🇸
Read 12 tweets
30 Dec 20
1/ People are hardwired to get infuriated when they see injustice.

But I fear that applying this lens to covid vaccine distribution will lead to more deaths not fewer.

Stanford has screwed up, again. Some people who shouldn't have gotten it, did.
nbcbayarea.com/news/local/rac…
2/ What's the natural response then, from those all the way down the distribution chain, from state administrators to hospital execs worried about "wrong people" getting vaccinated first?

You spend more time collecting data, parsing into finer and finer gradations

You slow down
3/ Hospitals and nursing homes don't release more to staff until every i has been dotted.

States don't release more to hospitals and nursing homes until they've used up allotment

feds don't release more to states

Amidst a vaccine shortage, available supply sits in warehouses.
Read 8 tweets
29 Nov 20
1/ Opening schools in the midst of a COVID surge is a hard problem with unavoidable tradeoffs.

There are absolutist statements on either side of the debate, so I expect passionate rebuttals, but let me lay out a decision-making framework, from an epidemiologists' perspective
2/ First off, we have to make sure that the schools have the resources and space to implement the 5 key mitigation
strategies correctly and consistently.

Not a given.

*Masks
*Social distancing
*Contact tracing
*Hand hygiene
*Cleaning and disinfection

first 2 >> last 2
3/ Let's say we have some resources for testing, how does that contribute?

What we are trying to achieve?

Do you think the goal is Screening (identify asymptomatic infectious cases before they can expose others) or Surveillance (understand incidence to inform policy)?
Read 22 tweets
15 Nov 20
1/ It's indescribable seeing results from NYC EMS ambulance runs showing how cardiac arrests skyrocketed during COVID

(I started a program to monitor these symptoms in real time--among the very first application of syndromic surveillance in public health, 2 decades ago)
2/ Every day, crews from @FDNY are called to 20 to 30 patients who have collapsed, and attempt resuscitation. Can you imagine?

It's never like the movies. Most patients die, ribs cracked. 75% of the time you never get a heart rate back.

On April 6, there were 305.

305.
3/ In the dry language of medical research the researchers describe the horrible statistics.

During the peak, most patients had nonshockable presenting rhythms of asystole and pulseless electrical activity. 92.2% of the time they called off the resuscitation without a pulse.
Read 7 tweets
11 Nov 20
1/ I've been feeling more and more disengaged from COVID work, disillusioned with the growing realization that all the smart research and policy doesn't make a damn bit of difference

Not for the 1st time, I've seen that what I thought was an information problem is something else
2/ I so admire those public health Cassandras who've been unrelenting, continuing to beat the drum of science and policy for the past 9 months

repeating over and over again what must be done, as the cases and deaths mount, with no strategy in sight

tweets, interviews, articles
3/ It's perhaps no accident that they (and I) are "formers"

People who ran the agencies, who know the pain of the experts and scientists working inside, and are free to speak

CDC @DrTomFrieden
FDA @ScottGottliebMD
CMS @ASlavitt
FDA/CMS @DukeMargolis McClellan
WH @ZekeEmanuel
Read 10 tweets
10 Oct 20
1/ Policy makers: Wait, Isn’t quality of care better at large expensive health systems c/w independent practices?

Previous Research: Ummm no. But we can keep looking

@AHRQNews What if we look at high needs patients?

@RANDCorporation It’s ... worse?

onlinelibrary.wiley.com/doi/abs/10.111…
2/ To test hypothesis that health systems provide better care to patients w high needs, diff in quality b/w system‐affiliated & nonaffiliated physicians

ED visits were significantly *different* in system‐affiliated (117.5 per 100) & nonaffiliated POs (106.8 per 100, P < .0001).
3/ I love how delicately the RAND researchers approach this in their conclusion: “Health systems may not confer hypothesized quality advantages to patients with high needs.”

(Then why do they get paid so much more?)
Read 4 tweets

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