New Oxford/AstraZeneca #covid19 vaccine pre-print. Pooled analysis of their phase 3 efficacy trials in UK & Brazil + phase 1/2 clinical trials in UK and South Africa.

17,177 volunteers overall
UK: 8,948
Brazil: 6,753
South Africa: 1,476

332 infections >14 days post dose 2
Overall vaccine efficacy for Oxford/AZ #covid19 vaccine >14 days after 2nd dose = 66.7%

Complete protection against hospitalization "after 21 day exclusion period." (15 hospitalizations in control group, none in vaccine group.)
Oxford/AZ report #covid19 vaccine efficacy of 76% with just a single shot, between Days 22 and 90.

Say antibody levels are maintained with minimal waning 3 months out.
Oxford/AZ preprint also goes into data on dose intervals:

2 standard doses 12+ wks apart = VE: 82.4%
2 standard doses <6 wks apart = VE: 54.9%

Binding antibody responses 2x+ higher in 12wk+ vs <6wks in people age 18-55 (what about older?)

Still reading papers.ssrn.com/sol3/papers.cf…

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More from @megtirrell

2 Feb
WH #Covid19 briefing now. @JeffZients says starting Feb 11, federal govt will deliver vaccines directly to select pharmacies across the country. Will provide more sites for people to get vaccinated in their communities and important component for vaccine equity.
.@JeffZients: #covid19 vaccine pharmacy program will include 6500 stores nationwide in the early phase before expanding. Warns though that many initially will have only limited supply.
Eventually up to 40k pharmacies nationwide could provide #covid19 vaccines, @JeffZients says. Notes overall effort also includes mass vaccination sites, mobile clinics, community health centers & other providers.
Read 6 tweets
2 Feb
Pfizer research chief just detailed on earnings call what sounds like an interesting divergence in #covid19 vaccine strategy re: variants compared with Moderna. Says Pfizer testing boosts of original vaccine at 6 and 12 months out. (1)
Pfizer's Dolsten notes mRNA vaccines generate high antibody levels, and expects even against B.1.351 & P1 variants that those levels mean the vaccines will be "much more resistant to breakthroughs."

Expects a booster w original vaccine may get antibody levels high enough. (2)
In contrast, Moderna has said it's already working on a new #covid19 vaccine construct, mRNA-1273.351, in case it's needed: investors.modernatx.com/news-releases/…

Moderna also testing booster w original (3)
Read 4 tweets
1 Feb
.@aslavitt46 announces Dept of Defense & HHS have awarded $230m to Ellume, maker of first OTC at-home #covid19 test.

Ellume to ship 100k test kits to US per month from Feb - July.

New funding will scale manufacturing capacity to 19m test kits/mo by end of year. 8.5m to US govt.
.@aslavitt46 on #covid19 vaccine supply: We believe some health-care providers are regularly holding back doses that are intended as 1st doses & instead keeping as 2nd dose reserves. We understand why, but it does not need to happen and should not happen.
.@aslavitt46: With 3-week window of visibility into vaccine supply, states & health-care providers should have predictability & not feel they need to reserve 2nd doses to ensure they'll have them.
Read 4 tweets
27 Jan
Dr Fauci slide on #covid19 vaccines and when results are expected, from first White House Covid-19 response briefing: Image
Dr Fauci slide on coronavirus variants of concern: Image
.@ASlavitt now presenting at WH #COVID19 response briefing. “It’s been a busy 7 days.” Image
Read 5 tweets
27 Jan
In this new pre-print from the lab of AIDS research pioneer David Ho, suggestions the B.1.35 variant (as expected) has a bigger impact on potency of both antibody drugs and #covid19 vaccines (1)
Neutralizing activity of Moderna & Pfizer vaccines declines only about 2 fold against B.1.1.7 variant, but 8.6 and 6.5 fold against B.1.351, Ho pre-print finds: (2)
On monoclonal antibody activity against the variants (SA9 is B.1.351.), one Regeneron antibody loses potency, but cocktail retains. Lilly single antibody & cocktail appear to lose potency against B.1.351. (Note Regn’s Christos Kyratsous is a co-author on paper) (3)
Read 5 tweets
21 Jan
Dr Fauci in the ⁦@WhiteHouse⁩ briefing room
Fauci: If you look at the 7-day avg of cases, right now it looks like it may be plateauing.

But you have to be careful it’s not an artifact of slowing down after the holidays.

“I’m sort of getting deja vu standing up here. I said something like this almost a year ago.”
Fauci: There are always lags so please be aware of that - cases, weeks later hospitalizations, weeks later deaths.

Cases may be plateauing or coming down at the same time hospitalizations and deaths are going up.
Read 11 tweets

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