Thread by @AnilvanderZee

Charité Berlin;

"Chronic COVID-19 Syndrome at months 6 is a multisymptomatic frequently debilitating disease fulfilling diagnostic criteria of ME/CFS in about half of the patients in our study."

#pwme #LongCovid

medrxiv.org/content/10.110…

medrxiv.org/content/10.110…

Mannose-binding lectin plays an important role in the body's immune response by attaching to foreign invaders such as bacteria, viruses, or yeast and turning on (activating) the complement system.

I'm curious if this was already present beforehand onset of the infection?

"In our patient cohort of younger patients with mostly mild
COVID-19, we have, however, no evidence for potential confounding organ impairment
or major depressive or anxiety diseases in accordance with other reports."

"Furthermore, in this (another) study
a minority of patients had evidence for depression or anxiety in line with our data,
providing evidence that despite a high illness burden mental health is not relevantly
impaired in most patients with CCS."

"Our study provides evidence that patients following mild COVID-19 develop a chronic
syndrome fulfilling diagnostic criteria of ME/CFS in a subset. We must anticipate that
this pandemic has the potential to dramatically increase numbers of ME/CFS patients.
At the same time"

it offers the unique chance to identify #MECFS patients in a very early stage of disease, so that interventions such as pacing and coping can be applied early
with a better therapeutic prognosis. Further, it is an unprecedented opportunity to
understand the pathomechanisms &"

characterize targets for specific treatment approaches"

In other words very interesting for #pwME, #LongCovid and many other "post"-infectious conditions.

Encore!!!! ✌️

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