I’m really struggling with this idea of a race to vaccinate everyone HERE now. Yes, we all want vaccine asap. But while we are discussing how soon we can immunize everyone in Germany or the US, health workers are dying in countries with zero doses so far.

sciencemag.org/news/2021/02/u…
In Zimbabwe, one of the top doctors and HIV/AIDS researchers, James Hakim, died in late January.
As his colleague and former student Leolin Katsidzira told me: "people like James are people who keep the system going”.
Here is one of many tributes: kcl.ac.uk/news/tribute-t…
Hakim’s death came within hours of the death of David Katzenstein, another important HIV/AIDS researcher and voice for global health, in the same hospital in Harare.
Here is a good piece on him and his work:
med.stanford.edu/news/all-news/…
I talked to Emilia Noormahomed in Mozambique who told me about recent deaths there: An anesthesiologist, a gastroenterologist, a urologist. And two young general care physicians, who were not even 30 yet. It was heartbreaking.
These are just examples of what the continent is losing, what the world is losing.
More than 180 million doses have been given. The US is administering more than a million doses A DAY.
And look at sub-Saharan Africa on this map
(bloomberg.com/graphics/covid…)
And while every death is a tragedy, losing a health care worker in a place like Zimbabwe or Mozambique, where health care is stretched sooo thin, has much bigger effects than in the US or Germany. As @ashishkjha told me: “It will literally take an entire generation to rebuild”.
@ashishkjha As @DrTedros said recently: "The world is on the brink of a catastrophic moral failure”.
And it’s not just about vaccines, it’s about therapeutics like tocilizumab, it's about ventilators, oxygen, masks.
@ashishkjha @DrTedros Has the US done enough?
Robert Schooley told me: “We have worked with our counterparts in sub-Saharan Africa for 20 years to try to help them build a more resilient health care infrastructure and we’re sitting on our hands watching that be torn apart by the coronavirus.”
@ashishkjha @DrTedros But this isn't really about what the US has done or Germany, or even about Africa. It’s about the simple fact that we are dealing with a pandemic, a global catastrophe, and the smartest, fastest, and yes, most decent way out of it is to always think globally while acting locally.

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More from @kakape

15 Feb
"The number of reported cases of #COVID19 globally has now declined for the fifth consecutive week”, says @drtedros at @WHO presser.
"The number of weekly reported cases has fallen by almost half” in 5 weeks, from more than 5 million to 2.6 million cases."
@DrTedros @WHO "What matters now is how we respond to this trend”, says @DrTedros.
"The fire is not out, but we have reduced its size. If we stop fighting it on any front, it will come roaring back."
@DrTedros @WHO Good news:
"Today, @WHO gave emergency use listing to two versions of the Oxford-AstraZeneca #COVID19 vaccine, giving the green light for these vaccines to be rolled out globally through COVAX”, says @drtedros.
Read 24 tweets
12 Feb
“I wish to confirm that all hypotheses remain open and require further analysis and studies”, says @drtedros about origin of #covid19 at @WHO presser. Calls the origins mission "a very important scientific exercise in very difficult circumstances”.
@DrTedros @WHO "The expert team is working on a summary report which we hope will be published next week”, says @DrTedros.
“The full final report will be published in the coming weeks.”
@DrTedros @WHO “The number of reported cases of #COVID19 globally has declined for the 4th week in a row and the number of deaths also fell for the 2nd consecutive week” says @DrTedros. "This decline appears to be due to countries implementing public health measure more stringently."
Read 13 tweets
11 Feb
Good news (again) from the UK’s impressive Recovery trial:

Tocilizumab reduced deaths from #COVID19 by about 4% and that was on top of dexamethasone.
It means that giving 25 people this drug on top of the standard of care will lead to one saved life.
Tocilizumab also reduced the need for a mechanical ventilator and shortened the hospital stay.

All of this is from press release for now: recoverytrial.net/news/tocilizum…
Manuscript is working its way through medrxiv right now.
Tocilizumab is an anti-inflammatory drug, an antibody that targets the IL-6 receptor, dampening the immune system. It is used to treat rheumatoid arthritis.

It is also about 100x as expensive as dexamethasone, so it will probably increase the global inequities of this pandemic.
Read 4 tweets
9 Feb
Press conference on what @WHO-convened mission to investigate the origins of #SARSCoV2 found on their China trip is about to start in Wuhan.
(Was originally supposed to start an hour ago before being pushed back)
@WHO It finally started this minute.
@WHO After a lengthy introduction of the mission and its terms of reference, Liang Wannian, who leads the Chinese team of the joint mission, says he will now begin to talk about the key findings, starting with molecular epidemiology.
Read 29 tweets
8 Feb
“It seems increasingly clear that manufacturers will have to adjust to the evolution of the virus, taking into account the latest variants for future shots, including boosters”, says @DrTedros at @WHO presser. “We have to be ready to adapt vaccines so they remain effective."
@DrTedros @WHO "These developments highlight why it's so important to scale up manufacturing and rollout vaccines as quickly as possible and as widely as possible to protect people before they're exposed to new variants”, says @drtedros.
@DrTedros @WHO “We need to do everything we can to reduce circulation of the virus with proven public health measures”, says @DrTedros. "Several countries are succeeding in suppressing transmission including those where new variants are circulating."
Read 30 tweets
4 Feb
I‘m struck that it still hasn’t sunk in how much #b117 may change the course of this pandemic.

The initial shock about it being more transmissible seems to have worn off. But we are barely beginning to see its real-world impact.

A story: sciencemag.org/news/2021/02/d…
And a thread
After #b117 was identified in England and seemed to be taking off there, many people like me started looking at Denmark for clues.
Why Denmark? It sequences a lot! Here is a graph from @ECDC_EU from late December showing EU sequencing (look at B and note that it’s a log-scale):
@ECDC_EU Denmark has actually massively scaled-up its sequencing since then.
@MadsAlbertsen85 and his team, who have basically been doing all the sequencing for the whole country, are now getting close to 70% which is about as much as is possible (30% have low virus concentrations).
Read 15 tweets

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