ca 600,000 vaccinated with BNT-Pfizer vaccine in Israel, matched on demographic/clinical characteristics of 600,000 unvaccinated (median age 45) showed results similar to the phase 3 trial... 1/n nejm.org/doi/full/10.10… 
...Similar pattern, for infection, symptomatic Covid-19, hospitalization, severe disease, death: 10,561 people infected, 57% of them developed symptoms; 369 in hospital, 229 severe Covid-19, 41 deaths...2/n
...7 days after 2nd dose: 92% efficacy against infection (CI: 88 to 95) - that's a strong result. Hospitalization: 87% (CI: 55 to 100) - wide confidence intervals, so not so certain. Remember, it's a group on the young side...3/n
...The group is on the young side, because so many older people were vaccinated so fast, it was harder to get a matched group of unvaccinated older people in that time...4/n
...Vaccine efficacy was similarly high in older people, including over 70. The study doesn't analyze for variants, but at that time, up to 80% of infections in Israel were B.1.1.7 ("UK" variant), & B.1.351 "SA" variant was rare. /5
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