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Mac n’ Chise 🧬🧫🦠 Profile picture
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25 Feb, 4 tweets, 2 min read
In relevance to the scaremongering going around right now concerning the New York variant B.1.526, let me save you all from having to click and scroll down the article.
This variant has not been shown yet to possess any evidence of functional significance or biological properties that make it a cause for concern to date. Please be aware.
Also for those getting upset at me saying people have a right to know about it, yeah you’re right. I absolutely agree. What do you think I’m doing? They also have a right to know what’s past your clickbait headlines and why they don’t need to be thrown into a panic.
If you did not see it yesterday, the preprint concerning this variant is up and apparently this article was out before it. To this date, the only VOCs are B.1.1.7, B.1.351 and P.1. This variant is not expected to be a concern. medrxiv.org/content/10.110…

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Mac n’ Chise 🧬🧫🦠 Profile picture
26 Feb
Ready for some wonderful news? Here we go! A recent study has found that a single dose of Pfizer’s vaccine can reduce the number of asymptomatic SARS-CoV-2 infections by 75%. This demonstrates these vaccines can greatly reduce the risk of transmission. 🧵
authorea.com/users/332778/a…
Cambridge University Hospitals NHS Foundation Trust and researchers at the University of Cambridge analyzed their results from thousands of COVID-19 tests carried out each week as part of their screening program on asymptomatic HCWs who showed no signs of infection.
Their vaccination program for HCWs began on December 8th of last year, with mass vaccination efforts continuing til January 8th of this year. During a two-week period between the 18th and 31st of January, researchers screened similar numbers of vaccinated and unvaccinated staff.
Read 9 tweets
Mac n’ Chise 🧬🧫🦠 Profile picture
24 Feb
Some good news for your evening! Now that it’s finally out I can share! Our updated mRNA-1273.351 Moderna vaccine is on its way to NIH to be tested in early stage clinical trials to determine if it can be used as a booster shot against variant B.1.351 (South Africa strain)!
Yes. We had this ready to go in 30 days. Working hard!
You can find more here: businesswire.com/news/home/2021…
Just so you guys have an idea on the approaches to boosting we are evaluating (also note that while YES, our vaccines do provide neutralizing activity against VOCs we are choosing to do these studies out of an abundance of caution and stay ahead):
Read 7 tweets
Mac n’ Chise 🧬🧫🦠 Profile picture
24 Feb
The FDA Vaccines and Related Biological Products Advisory Committee briefing document on Johnson & Johnson’s COVID vaccine has been posted and their efficacy data looks extremely promising. It appears to elicit robust efficacy against all variants including B.1.351!
It also demonstrates its ability to elicit strong cell-mediated immunity via T-cell responses with protection rising over time. This is the first one-dose vaccine that could do a lot of wonders right now. EUA is expected this week.
Document is here:
fda.gov/advisory-commi…
The efficacy of the Johnson & Johnson vaccine against moderate to severe/critical COVID-19 across all geographic areas was 66.9% at least 14 days after the single dose vaccination and 66.1% at least 28 days after vaccination. In addition, there were no specific safety concerns
Read 11 tweets
Mac n’ Chise 🧬🧫🦠 Profile picture
22 Feb
Wonderful news this morning! A study out of Scotland has found by the fourth week after receiving an initial dose, Pfizer’s and Oxford-AstraZeneca’s vaccines were shown to reduce the risk of hospitalization from COVID in Scotland by up to 85% and 94%, respectively!
Also keep in mind this is just after the initial dose! This means we have more encouraging numbers to look forward to after individuals receive their booster. This is why every vaccine is vital. One study alone does not determine its value.
While we are waiting for the preprint Daily Mail UK provided some graphics from the study. Researchers specified the risks only appear to wear off after four weeks because of a lack of data- not because immunity wears off.
Read 8 tweets
Mac n’ Chise 🧬🧫🦠 Profile picture
20 Feb
This is SO encouraging! More data out of the study conducted by Pfizer and Israel’s Health Ministry I spoke about on a recent thread shows increased effectiveness of Pfizer’s across the board 14 days from the second dose. Remember that second dose is vital!
95.8% at preventing SARS-CoV-2 infection
98% at preventing disease with fever or respiratory symptoms
98.9% at preventing COVID-19 hospitalizations
99.2% at preventing severe disease
98.9% at preventing death from COVID-19
That’s real-world data for you!
Also yes, let me clarify, they specified this was regardless of whether asymptomatic infection or not. I think we need to really start acknowledging these vaccines do indeed reduce transmission of SARS-CoV-2.
Read 4 tweets
Mac n’ Chise 🧬🧫🦠 Profile picture
20 Feb
Vaccines are preventives, not cures.
The purpose of vaccination is to bring the severity level down to that of a benign virus. That’s how this works. Our best protection is to keep cases low and get people vaccinated. To expect eradication of this virus right now is unrealistic.
With this said, the more people vaccinated, the more restrictions should start to be lifted. Why? We are already starting to see evidence these vaccines do prevent transmission the more data comes out; it would be extremely ignorant to suggest otherwise or disregard it.
Eradicating this virus right now from the world is a lot like trying to dig a tunnel to the center of the Earth using only a plastic spoon. It’s unrealistic. Some forget or simply don’t care (totally different virus) but Polio was endemic before it was 100% declared eradicated.
Read 13 tweets

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