THREAD on COVID and DEPRIVATION:

As cases recede nationally, some areas remain stubbornly high. Many have been persistently high for months. Deprivation is an important aspect of this.

This is a tour of deprivation & covid & what it means

(21 tweets but pls read).
2. First, how is deprivation measured? Usually by the "Index of multiple Deprivation". This assigns a value to every neighbourhood (~7000 people) based on 7 domains of deprivation.

arcgis.com/apps/Cascade/i…
3. All neighbourhoods (technically MSOAs) are then ranked in order of deprivation and split into 5 equally sized groups ("quintiles"). Every person in population can then be assigned to one deprivation quintile from most deprived to least deprived based on where they live.
4. There are roughly the same number of people in each deprivation quintile - so the population is split into 5 equal-ish sized groups.

Impact of deprivation shows up when look at other outcomes by deprivation which will not be equally sized by deprivation.

So...
5. If we look average case rates per 100,000 people per week by deprivation in England since September, we see that the more deprived communities have markedly higher case rates.
6. This disparity gets *worse* in lockdowns, as people from more deprived areas remain much more exposed to covid as they go out to work, have kids in school, can't self isolate etc...
7. People in deprived areas are also more likely to get *sicker* if they catch Covid. We can see an even starker gradient in who needs intensive care for Covid from ICNARC data.
8. Looking at population, cases and ICU together, this progression is clear. Cases are more skewed to deprivation and ICU admissions more still.

We know ethnicity and deprivation big risk factors.
theguardian.com/world/2021/feb…
9. What is contributing to this? Partly it's that key workers (inc taxi drivers, security guards etc) are more likely to get covid. They are also more likely to come from deprived & BME communities & have other health problems.

oem.bmj.com/content/early/…

ons.gov.uk/peoplepopulati…
10. Partly it's that people on low incomes or in poor housing cannot isolate - and that also prevents people getting tested!

bmj.com/content/372/bm…
11. Housing is also a big issue - we know from REACT study that lots of people living in the same house is a big risk factor. Poor housing is also associated with other health conditions making severe illness from Covid more likely
health.org.uk/news-and-comme…

health.org.uk/publications/l…
12. We also know that people in deprived areas have worse access to green spaces. This will matter more & more as we head into summer & more outdoor activities. Not only are green spaces good for mental health, but also for avoiding riskier indoor spaces.

blogs.bmj.com/bmj/2020/07/03…
13. So how is this playing out as the 2nd Covid wave recedes?
14. Cases and positivity rates are coming down in all nations, but are flattening off in Scotland, England & Wales. This is mirrored in more local data. E.g. in Scotland positivity rates are rising in many areas.
15. In England, a divide is again emerging with higher rates in the North & Midlands which are flattening off compared to London, East & South.
16. Surprise Surprise, the regions in England with the highest resideual rates of Covid are also those with more deprived areas.
17. If we look at top 30 local authorities who have been persistently above 200 cases / 100K people / wk since September, most of them are again in the top 40 local authorities now (orange rows).
18. It's a similar picture in Scotland (top 15 local authorities with persistently high cases and ones that are in the top 15 places now).
19. So we are seeing persistently high cases in many of the same areas that saw increased restrictions and cases all last autumn.
Worse, people in deprived areas are also less likely to have had a vaccine dose.
20. Although, for vaccine uptake, ethnicity is a bigger driver than deprivation (although there is a lot of overlap between the the two).
news.sky.com/story/covid-19…

This might explain why London is lagging so much.
21. As we emerge from lockdown, we MUST tackle these issues.

It's not only very unfair for Covid to become a "disease of poverty", it also risks continued large outbreaks & emergence of new vaccine-resistant variants.

As a lancet editorial said:
thelancet.com/journals/lanin…

END

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Christina Pagel

Christina Pagel Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @chrischirp

23 Feb
1. LONG THREAD ON COVID, LOCKDOWN & THE ROADMAP:

TLDR: There’s a lot to like about the roadmap – but it could be & should be made much more effective.

Because this will be tying current situation to the roadmap, I’m concentrating on English data

Read on… (22 tweets - sorry)
2. Firstly, cases across England are falling. This is good news but the pace of reduction is slowing.

England has the highest case rate in the UK and the nations with lower case rates (on the order of 100 cases/100,000 pop/week) are plateauing even more
3. The worry is that the more transmissible new strain + many people still out at work, often in non-Covid safe workplaces, means it might be hard to get much below 100/100K/wk , esp in deprived areas, even under current restrictions.

The new strain now dominant everywhere.
Read 23 tweets
22 Feb
This article by @bealelab explaining the different Covid variants, possible impacts on vaccine effectiveness & future of the pandemic is quite simply one of the best I've ever read. lrb.co.uk/the-paper/v43/…

Some key bits highlighted below!!
This bit explains how vaccines tartget lots of different bits of Covid to provide protection - so that even if the virus gets better at one bit, vaccines can still work by stopping other bits. This is what the case with B117 (the Kent strain).
this section highlights the success of the UK vaccination programme so far
Read 5 tweets
21 Feb
THREAD ON LONG COVID & KIDS:

TLDR: I don't think we should ignore it.

ONS Infection survey updated its estimates for Long Covid a couple of weeks ago.

assets.publishing.service.gov.uk/government/upl…
It showed that 13% of under 11's and about 15% of 12-16 yr olds reported at least one symptom 5 weeks after confirmed Covid-19 infection.

ONS samples households randomly - so positive cases do not depend on having had symptoms & being tested.
Many have criticised this data because there is no comparator group of kids who had *not* tested positive for Covid and because some of the symptoms are common in childhood. (e.g. fever, cough)

These are perfectly valid criticisms and ideally we would have that.

BUT
Read 16 tweets
18 Feb
QUICK THREAD ON LATERAL FLOW DEVICE (LFD) TESTS:

LFD tests are mainly used for testing people without symptoms and PCR tests are used for those with (new) symptoms.

LFD tests now outnumber PCR tests every week. 1/4
Unsurprisingly positivity rates for PCR tests are much higher than for LFD tests. Reassuringly positivity rates are coming down in both cohorts.

BUT if we are relying more on more on LFD tests then we *must* use them carefully! 2/4
Firstly, they should NEVER be used as a "green light" to indicate no infection - only as a "red light" to indicate that you've got Covid and should isolate.

Do a confirmatory PCR for positive LFDs to minimise false positives & ENSURE support for isolation! 3/4
Read 5 tweets
15 Feb
THREAD ON UK VACCINATION PROGRAMME:

TLDR: At 3 mill doses/week expect a big slowdown in *first* doses in April/May. But then summer ramp up to vaccinate all adults by early September.

Increasing to *6 mill/wk* for *6 wks* in April/May could vax everyone by mid July. 1/6
This is where we are now (latest weekly data to 7 Feb). Almost all vaccinations are first dose now.

Vaccination numbers levelling out at about 3 million a week.

But in early March we need to start giving 2nd doses... 2/6
*If* we stay at 3 mill/wk doses, by May ALL those 3 mill doses will be spent giving 2nd doses to people vaccinated in Feb.

In June 1st dose ramps up again & all adults offered 1st dose by end July. Using 3 mill/wk for 2nd doses means all offered 2 doses by early Sept

BUT 3/6
Read 8 tweets
12 Feb
1. THREAD on latest UK Covid Numbers:

A reasonably detailed dive into the latest numbers & (some) implications.

TLDR: things going in right direction but don't think unlocking will be easy.
2. Confirmed cases are still falling & we are back at levels last seen in early December. Positivity rates (accounting for changes in numbers of tests) are also falling in all 4 nations (and in all age groups).

ONS infection survey entirely consistent with this picture.
3. Cases and positivity rates also falling across all English regions & LAs. However, E. Mids, Yorks & Humber and N.East falling slowest.

Obviously falls are GOOD, BUT the green diamonds show where we were at the end of Aug last year.

There is a LONG way to go.
Read 20 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!