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Martin Juhl Profile picture
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8 Mar, 9 tweets, 4 min read
A couple of interesting papers on 25-Hydroxyvitamin D Level and link to reduction in Infections
1/x
 jamanetwork.com/journals/jamas… Image
"Vitamin D levels may constitute a modifiable risk factor for postoperative nosocomial infections in hepatobiliary surgery patients."
2/x
 journals.plos.org/plosone/articl… Image
"Practice improvements of comparable potential magnitude with negligible cost & exemplary safety & efficacy are rare, & raise deliberation of the ethical implications of choosing not to test for, & not to treat, low vit D status in advance of surgery"
3/x
 link.springer.com/article/10.118…
New DK paper links low vitamin D and risk of bacterial pneumonias
4/x
Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data
5/x
 bmj.com/content/356/bm… Image
Vitamin D supplementation to prevent acute respiratory infections: systematic review and meta-analysis of aggregate data from randomised controlled trials
6/x
 medrxiv.org/content/10.110… Image
WHO: 3 of the reviews consistently showed a benefit of vitamin D supplementation for preventing respiratory tract infection mainly in children younger than 16 years.
7/x
 who.int/elena/titles/c…
Vitamin D3 replacement can boost antigen-specific immunity older adults
8/x
Thus, overall the data points towards 25-(OH)-vitamin D levels have a small, but real impact on outcomes , but it is not too be hyped as a miracle treatment either.

Furthermore, it is important to understand the difference between Cholecalciferol/calcifediol/calcitriol
9/x Image

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More from @MartinJuhl2

Martin Juhl Profile picture
10 Mar
Hvor mange får senfølger?
Stadig et svært spørgsmål at få svar på, men studiet fra King's College London er nu publiceret
➡️13.3% med symptomer ≥28 dage
➡️4.5% ≥8 uger
➡️2.3% ≥12 uger
Risiko for senfølger korrelerer med alder, BMI og at være kvinde
1/4
 nature.com/articles/s4159… Image
Vi kom med et ikke helt skæv analyse og bud sidste år i videnskab.dk med et gæt på 1-2% efter 3 måneder
"Flere studier tyder på, at minimum 1-2 procent af de smittede vil ende med senfølger efter en COVID-19-infektion"
2/4
 videnskab.dk/forskerzonen/k… Image
Her er en gammel tråd om emnet med flere artikler
3/4
Read 4 tweets
Martin Juhl Profile picture
9 Mar
Here are cases in Denmark, Sweden, Norway, and Finland for the last 3 weeks, adjusted to Denmark's population size
1/x Image
If one also tries to adjust for both population size & number of tests performed in DK (DK tests a lot), using SSI's correction factor of [test ratio]^0.7, it looks like this 👇
2/x Image
Although, this does not entirely fit with the ratio of Covid-19 deaths registered in each Country. It might have something to do with delay in reporting, or the fact that there are around 3 week from test to death, or the test-adjustment might not apply to other countries
3/x Image
Read 6 tweets
Martin Juhl Profile picture
6 Mar
Det bliver ved med at komme rigtig gode nyheder ud omkring vaccinerne - det lover godt for fremtiden

Effekten der er observeret i de kliniske studier er nu blevet bekræftet efter udrulningen i mange lande. Især data fra Israel, England, Scotland og Danmark ser imponerende ud
1/x
Flere datapunkter tyder nu på at Astra-Zeneca/Oxford er ligeså god eller bedre end Pfizer/BioNTech og Moderna på flere parametre.
economist.com/graphic-detail…
2/x
I de kliniske studier blev der kun målt på (1) hvorvidt man så et fald i antal smittede med symptomer. Der lå effekten mellem 60-95%.
3/x
Read 12 tweets
Martin Juhl Profile picture
6 Mar
For the first time since the beginning of the pandemic, Denmark now have the fewest cases of the Nordic countries below
1/x
Denmark is testing the most
2/x
and Denmark have the lowest test positive percentage, meaning DK is most likely identifying more cases, than the other countries
Example:
if you test 50.000 and find 308 cases
if you instead tested 100.000 you would find 500 cases
and 150.000 test would find 664 cases
3/x
Read 12 tweets
Martin Juhl Profile picture
29 Jan
A list of restrictions introduced in Sweden

-Restriction on restaurants (max 4)
-high schools closed
-Restrictions on shops
-Masks recommended in public transportation
-Border control to Denmark
-No alcohol after 8pm
-Restrictions on gatherings (max 8)

nyheder.tv2.dk/udland/2020-12…
From mid-November
From early November
Read 5 tweets
Martin Juhl Profile picture
28 Jan
Population Fatality Rate (PFR) comparison of COVID-19 vs seasonal influenza (Average flu season)

PFR is how many deaths out of the entire country population

Current Covid-19 deaths vs historic flu deaths
1/x Image
Population Fatality Rate (PFR) comparison of COVID-19 vs seasonal influenza (worst flu season in recent years)
2/x Image
The median R value for seasonal influenza was 1.28

bmcinfectdis.biomedcentral.com/articles/10.11…

R0 value of SARS-CoV-2 is estimated at 2.5

thelancet.com/pdfs/journals/…

Herd immunity threshold (HIT) = 1 - 1/R0

Flu HIT = 22%
SARS-CoV-2 HIT = 60%

3/x ImageImageImage
Read 6 tweets

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