Thread by @JCedernaes

Not possible to review yet, so very preliminary:

German researchers seem to claim that in some individuals - that is, in very few as reported elsewhere - the Astrazeneca vaccine may activate platelets (which regulate clotting)
ndr.de/nachrichten/me…

The upside is that they seem to think they know how to treat these rare complications:

"The discovery means that targeted treatment can be offered to those who suffer similar clotting, using a very common medication."

m.dw.com/en/astrazeneca…

3) Some more details regarding the possibility of the rare clotting/bleeding complications following the Astrazeneca vaccine, and how to possibly treat the more serious type of them:

explica.co/german-scienti…

4) "What has happened in these cases looks a lot like a disorder called heparin-induced thrombocytocemia, where blood platelet levels also drastically decrease between 5 and 14 days after starting treatment with heparin (an injectable anticoagulant compound)"

5) "The solution to thrombi would go through inject high doses of immunoglobulin intravenously.

Greinacher et al’s findings have already been reported to the German Research Society for Thrombosis and Haemostasis, which has updated its guidelines for dealing with these events"->

6) -> That updated document can be found here: gth-online.org/stabsstelle-le…
Pdf:
gth-online.org/wp-content/upl…

7) For more regarding IvIg treatment of hepartin-induced trombocytopenia (HIT), see this review:

"distinct pathogenesis involving anti-PF4/polyanion antibodies that activate platelets strongly through clustering of platelet FcγIIa receptors" ->
pubmed.ncbi.nlm.nih.gov/31274032/

8) -> "IVIG is usually effective in interrupting platelet activation by aHIT antibodies, manifesting as a rapid platelet count increase after starting IVIG (usual dose, 1g/kg × 2 days). Experience to date suggests IVIG de-escalates HIT and likely reduces thrombotic risk"