Discover and read the best of Twitter Threads about #reinfection

Most recents (21)

Latest @WHO #TechnicalBrief on #Omicron
Overall risk remains very high & threat depends on

1⃣Transmissibility of #variant
2⃣How protective vaccines & prior infection are
3⃣Virulence of variant
4⃣Understanding of dynamics & uptake PHSM

Full 🧵👇 (1/)
who.int/publications/m…
Epidemiology (1)
-#Omicron has large growth advantage over #Delta - grows significantly more than Delta in countries with community transmission
- Evidence that immune evasion contributes to rapid spread
-Wk 52, global weekly #COVID19 incidence ⬆️ 71% compared to prior wk
(2/)
Epidemiology (2)
-Study from HK found #Omicron infects human bronchus tissue faster and better than #Delta
-#UK study found Omicron outcompetes Delta in experiments using cells derived from human nose, but not seen in lung derived cells
-Growth advantage in upper resp tract
(3/)
Read 17 tweets
This tweet thread is about the #Covid_19: Updates from Singapore webinar on 26 Feb 2021

I've been busy so this is ~ a month after

It will be followed by a tweet thread documenting a more recent episode that was last week
#Covid_19 : Updates from Singapore is a webinar organised by @WHOGOARN and @NUSMedicine

And moderated by @profdalefisher, Prof. David Allen, and Dr. Louisa Sun
We are joined tonight by Dr. Peter Karim Ben Embarek
Read 51 tweets
1) A Danish study @TheLancet has followed over 520 000 people, from the 1st to 2nd surge.

Similar to some other studies, they find that those with a prior #SARSCoV2 infection had ~80% lower risk of #reinfection, but only ~47% reduced in those ≥65 yrs
🧵
thelancet.com/journals/lance… Image
2) The @TheLancet article describes how Denmark during tested ~0.5 M people for #SARSCoV2 during wave 1.

At the end of 2020, ~10% of the population tested every week.

In all of 2020, Denmark tested ~4 million people (68% of their pop.) and 64% of those had been tested >1 time.
3) In their analysis, they also included an alternative cohort, that looked at individuals throughout the pandemic (& not only those testing positive in the 1st & 2nd wave), thus examining reinfection risk in a group of 2.4 M people, of which 28 875 had been previously infected.
Read 12 tweets
Meanwhile in #France,
"the peak of this second wave is over"

(according to the President in his Adress to the Nation):
Wait... "the peak is over" doesn´t mean "it´s back to normal"!

Confinement will only fall on December 15,
if there´s less than 5.000 new cases a day.
(today it´s ~9.000).

France is disappointed.🙁

Although they certainly can make it happen.
Meanwhile in #Switzerland:
(excess mortality of the second wave is significant)

Good news: fastest decrease in infections happens in the worst hit areas now.
Image
Read 2817 tweets
‼️First #COVID19 death confirmed in a person *REINFECTED* with the #coronavirus.

Although other #SARSCoV2 reinfections have been confirmed, this is the 1st DEATH after reinfection known in the world.

<Thread>

#COVID19 #WearAMask
cnn.com/2020/10/13/eur…
The elderly woman had Waldenström's macroglobulinemia (rare blood cancer) & was receiving therapy to deplete B cells that make antibodies ("humoral immunity"). However, her T cells, which work to kill virus-infected cells (cell-mediated immunity), should NOT have been affected.🦠
The woman was initially admitted into hospital earlier this year with a severe cough + fever and tested positive for the #coronavirus. She was discharged 5 days later when "besides some persisting fatigue, her symptoms subsided completely."

#COVID19 #Reinfection
Read 11 tweets
#Coronavirus Reinfection:

🧬1st infection: April (symptomatic)

🧬2nd infection: June (symptomatic*)

*Required hospitalization, O₂

🧬Two virus genomes differed by 11 nucleotides

▪️Case A: 4 variants not in case B

▪️Case B: 7 variants not in case A

👉thelancet.com/journals/lanin…
SARS-CoV-2 #Reinfection:

🧬4 reversions to ref genome proves 2nd infection not tied to 1st infection

🧬2nd infection caused by new infection, not prolonged viral shedding

🧬Patient tested positive for IgM/IgG against SARS-CoV-2 nucleoprotein when hospitalized for 2nd infection
4 Reversions:

🧬Calculate the probability that 4 variants in 1st infection (Case A) [that aren’t in 2nd infection (Case B)] mutated back to ref genome

🧬It’s the only way 1st infection could have mutated to become 2nd infection

🧬= ~1 chance in 10^18

🧬Odds exceedingly remote
Read 3 tweets
(48) US #COVID19 Daily New Cases per 1M pop by State
in Descending Order, on September 27th, 2020

Courtesy of @Worldometers ImageImage
(49) US #COVID19 Daily Deaths per 1M pop by State
in Descending Order on September 27th, 2020

Courtesy of @Worldometers ImageImage
(50) @Reuters US COVID-19 Confirmed Cases SITREP at a Glance. Image
Read 710 tweets
First report of #COVID19 #reinfection from #India - two #asymptomatic health workers identified on routine #surveillance
academic.oup.com/cid/advance-ar…

#CSIRfightsCOVID19
#Genome sequencing of the #SARSCoV2 isolates from both the episodes suggest distinctly different virus , confirming reinfection.
Since the individuals were #asymptomatic during both episodes, and identified on regular #surveillance suggest asymptomatic #reinfections could be an under-reported entity. 2/2
Read 5 tweets
1/ 46 yaşındaki Ekvadorlu bir adam, Mayıs ayında #COVID19’u hafif olarak geçirip iyileştikten sonra, Ağustos’ta #SARSCoV2 virüsü ile yeniden enfekte olup bu sefer ağır bir şekilde hastalandı. Bu tespit edilen 5. reenfeksiyon vakası. eluniverso.com/noticias/2020/…
#Reinfection #Immunity
2/ Hong Kong, Belçika ve Hollanda’daki asemptomatik vakalardan sonra ilk kez Amerika’da bir kişide ağır bir enfeksiyon tekrarı yaşanmıştı: Yüksek ateş, bağ ağrısı, ağır öksürük gibi belirtiler görülmüş, Nevadalı hasta belli aralıklara solunum cihazına bağlanmak zorunda kalmıştı.
3/ Amerikalı vakada olduğu gibi, Ekvadorlu vakada da mutasyona uğramış iki farklı #SARSCoV2 göze çarpıyor. İkinci enfeksiyonda beklendiği üzere belirgin IgG artışı gözlemleniyor fakat kişiyi ağır hasta olmaktan kurtaramıyor. Temmuz’da yapılan PCR kontrolü(-) Bağışıklık neden yok? ImageImage
Read 4 tweets
#Coronavirus Reinfection:

🧬1st infection: March (symptomatic)

🧬2nd infection: August (asymptomatic)

🧬Two virus genomes differed by 24 nucleotides

🧬Proves that 2nd infection was not tied to 1st infection

🧬2nd infection caused by #reinfection, not prolonged viral shedding ImageImageImage
Neutralizing Antibody:

🧬Tested NEGATIVE for IgG against SARS-CoV-2 nucleoprotein 10 days after symptom onset of 1st infection AND 1 day after hospitalization for 2nd infection

🧬Thus unknown if patient mounted neutralizing antibody response to 1st infection, didn’t last if yes ImageImageImageImage
Immune Response Following 2nd Infection:

🧬Patient tested POSITIVE for IgG against SARS-CoV-2 nucleoprotein 5 days after hospitalization for 2nd infection

🧬Most patients do develop immune response to infection, unclear how #strong that immune response is and how long it #lasts ImageImage
Read 4 tweets
#JustIn: #HKU's microbiology team issued a press release suggesting the 33-year-old IT patient, who came back from #Spain, is the world’s first #Covid19 reinfected patient.

#Covid19
#coronavirus
From the #HKU report: Reinfection can occur just after a few months of recovery from the first infection. #SARS_CoV_2 may persist in the global population as is the case for other common-cold associated human coronaviruses, even if patients have acquired immunity.
Since the immunity can be short lasting after natural infection, vaccination should also be considered for those once infected person. Patients with previous #Covid19 infection should also comply with control measures such as masking and #socialdistancing.
Read 9 tweets
Evidence is clear that people are not getting reinfected at least in the short term. CDC says there are no confirmed reports to date of a person being reinfected with COVID-19 within 3 months of initial infection.
#CovidVaccine @daniellevitt22 #SARSCoV2

researchgate.net/publication/34…
Researchers are optimistic about the emerging data that says the human immune system will most likely fend off SARS-CoV-2 if exposed to the virus again. #covid19 #reinfection

Just now uploaded PDF on ResearchGate. Article covers all the latest evidence:
researchgate.net/publication/34…
Neutralizing IgG, Memory B/ T cells, #SARSCoV (T- cells after 17 yrs), Seattle Boat study (first direct human evidence), Karolinska Uni study, Common cold (cross memory #SARSCoV2), CDC controversy, ICMR. #covid19 @profshanecrotty @EricTopol @daniellevitt22
researchgate.net/publication/34…
Read 3 tweets
Special thread discussing #COVID19 reinfection evidence in Iran. I felt it is time to compile it in a separate thread from my daily ones.

/start
First of all, what we have is just simply anecdotal evidence that is not confirmed by PCR.

What is shocking to me, is the horde of experts flat out rejecting these reports, saying there is NO PROOF for reinfection yet.

/pre1
Bear in mind in a binary case (reinfection vs no chance of reinfection) with grossly asymmetric risk profiles, burden of proof is for the side with less risk (no reinfection). That is just basic risk management.

/pre2
Read 43 tweets
As #COVID19 cases are found to spread, #Melbourne (city of ~5 million) tries to contain them by going into #Lockdown.
(The interview features the idea of a dedicated #Quarantine building - that would actually help, I guess)...
"People acting as if the pandemic was over was 'not the answer, it is part of the problem' ".

"The virus had leaked from postcodes already under the stay-at-home orders to other parts of #Melbourne."
(and beyond, it is feared).
Due to #Melbourne's outbreak, neighbouring South Australia is about to completely close it's borders to #Victoria.

(Nearly) no exceptions. And those essential few who are allowed in, will have to wear facemasks the entire time...
Read 2915 tweets
Vorpommern-Greifswald district (where rejections of #Gütersloh residents took place, yesterday)
has specific rules:
"Those who return from international risk areas (out of Germany) or whose Corona-Warning App has alerted them, need to report to authorites"
kreis-vg.de Image
In fact, Mecklenburg-Vorpommern's Corona-ordinance really prohibits entry of people from international risk areas AND german risk areas as well.
It's just not prominently featured on their websites.

(Overlooked that myself, hence deleted earlier tweet)
landesrecht-mv.de/jportal/portal… Image
People from #Gütersloh district may have to scrap all their holiday plans anyway...

An official #Lockdown is just being announced for the entire district.
(for one week, as of now)
Read 2556 tweets
Thread on my #CovidDataProject: #ReOpenAmerica edition.

For those not familiar with my work, the original (and still primary) aim of my model was to answer the question, “Where would we be on #COVID19 deaths had @realDonaldTrump acted quickly and responsibly?” The answer is

1/x
is shocking. As of midnight UTC last night, we stood at 72,271 deaths, and my model shows 90.905%, 65,698 American souls, would still be alive had he acted quickly. In other words, this would have been another tragic but relatively small blip on the epidemic radar, similar in
scale to the #SwineFlu under @BarackObama. And that’s without taking into account the added deaths globally, those caused by America’s failure to act.

Another, secondary goal has been predictive, looking at trends to make an educated guess about where we’re headed. That’s

3/x
Read 18 tweets
Thoughts on upcoming #COVID19 #serology tests:
This is actually quite a challenge! (#Diagnostics often involve a lot of complexities). There is a lot of pressure to roll these tests out, but they need to perform well, or we do more harm than good. #MicroRounds (A thread)
WHY we need these soon:
1. Contact tracing.
2. Can be used to test if a vaccine is working during a clinical trial (70 of them ongoing right now, I believe)
3. Inform public policy makers about rate of asymptomatic cases + previous infections/exposures =informed decision making
How is developing a #PCR different than developing a #serology test?
1. #PCR tests detect viral RNA/DNA (in this case RNA) and can be pretty straight-forward in terms of development
2. #Serology relies on knowing about the #SARSCoV2 structure and how the human body responds.
Read 13 tweets
1/n A while back, there was some discussion on whether #COVID19 patients could get 're-infected'. The consensus opinion back then seemed that there were a few cases of those who had not fully recovered. Once you've got the antibodies, amirite? Only....
#Reinfection.
2/n Only, it looks like there have been actual confirmed cases #reinfection of #COVID19 in South Korea: 51. A very low rate of re-infection, but still a troubling question.
news.v.daum.net/v/202004061435…
3/n To read that above article, click the A inside a rotating 'circle' in the symbols on the upper right-hand side of the page. You will get a drop-down set of symbols, as shown in the screencap below; choose your favored translation from that.
news.v.daum.net/v/202004061435… Image
Read 18 tweets
With the #COVID19 outbreak, it is important to use language responsibly. Here is the first entry of our new #ContagiousWords series, defining the buzzwords and terminology dominating today's conversation. #Pandemic #PandemicsCost
@ilariacapua Language is powerful, so we must be sure and accurate in the ways we communicate science. #Epidemic #ContagiousWords #COVID19
Read 64 tweets

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