Proud to have written with @tracyhoeg, @doctortara, Dr. Daniel Johnson. Please read data on relative risks to children from COVID vs school closings. "Our next national priority should be to reopen all America's schools for full time in-person learning" thehill.com/opinion/health…
Important to know data, epidemiology, clear facts when making decisions: "COVID-19 deaths in children are tragic but rare. To put the mortality risk in perspective, in California, there were 14 deaths among children ages 5-17 from COVID-19 in 2020, lower than the number of
children who die of influenza in a typical year. COVID-19 also poses a much lower risk of death than suicides in youth... 213 deaths among 5-17 year olds in the U.S. from COVID-19 in the past 12 months...nearly three times as many deaths by suicide — 596 deaths — in
in 2018 the smaller cohort of children between the ages of 10 and 14...suggesting that suicide and mental health disorders continue to remain a much larger threat to children’s health than either COVID-19 or influenza". Kids need other kids, schools safe, US should open schools
"When our country is compared to the rest of the world, we are a clear outlier in our failure to return students to the classroom in a timely and science-based manner....Our choice to not prioritize the well-being of our children, especially the most disadvantaged, will be felt..
.. for decades. Every pandemic has groups disproportionately affected and, when it comes to COVID, we will look back and see it was our children, our elderly and our poorest...Mahatma Gandhi "true measure of any society can be found in how it treats its most vulnerable members.”
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Wanted to drill down a bit more about the importance of the T-cell response to SARS-CoV-2 to give you more reassurance of enduring protection from vaccines (even against variants). Technical article here but CD4/CD8 cells have role in both acute infection cell.com/cell/pdf/S0092…
But, importantly, in recovered infection to give you durable immunity, along with memory B cells. Latter simulated by vaccine-induced immunity (you didn't get acute infection, you stimulate the immune response so that you can't get infected if you encounter virus). If you
just measure antibodies, you are measuring "tip of iceberg" in terms of your immune response to natural infection or vaccination so always ask - what about T cell responses to either? (and eventually, memory B cells too which give you long durable immunity). In fact, authors
T cell thread: Wanted to address T cells a bit more and why I think the AZ vaccine actually would work to prevent severe disease against the B.1.351 variant (although the S. Africa trial was not allowed to continue to show this outcome). So, remember that immunity comprises two
arms - antibody responses and T cells. T cells are the major immune defense against viruses. For instance, since the HIV virus infects CD4 cells, those with advanced HIV are susceptible to severe viral (and parasitic) infections. So, HIV doctors think about "T cells" a lot! Ok,
as discussed before, T cell responses to natural infection or vaccines help protect you against severe disease with SARS-CoV-2. Some papers below on this: a functional T cell response will modulate the severity of disease if you get infected or after vaccination.
Well, the court date is March 22 as our city is suing SFUSD to open schools stating "SFUSD's failure to reopen schools when it is safe to do so violates children's state constitutional rights"; the horrific impact on mental health for children highlighted. sfcityattorney.org/2021/02/11/her…
In the meantime, despite all of the scientific data showing 3 feet is fine for distancing and the fact that many teachers are vaccinated now, the American Federation of Teachers is opposing the CDC changing their guidance form 6 to 3 feet nytimes.com/2021/03/17/us/…
Vaccination changes everything for teachers; distancing is immaterial with the safety of vaccines (remember CDC guidance unmasked/undistanced) so there is something else going on that is not clear theatlantic.com/ideas/archive/…
Good news! Hospitalizations continue to drop in US, greater drops in older ages, showing vaccine effect. Drop of 13.4k in last 7 day hospitalizations, from February 24th - March 15th. 50+ yielded 81% of the drop in last 7 day hospitalizations. Half of the beta.healthdata.gov/Health/COVID-1…
total drop came from 70+ (drop of 6.7k in last 7 day hospitalizations). COVID last 7 day hospitalizations drop most marked in older, what else could that be but vax?
-39.1% (Feb 24th/March 15th)
-21.2% (Feb 24th/March 7th)
-14.4% (Feb 24th/March 4th)
-12.1% (Feb 24th/March 1st)
70+ -- 10,355 vs. 12,399 vs. 13,814 vs. 14,616 vs. 17,019
-39.2% (March 15th)
-27.1% (March 7th)
-18.8% (March 4th)
-14.0% (March 1st) ......
60-69 -- 6,505 vs. 7,244 vs. 7,820 vs. 8,096 vs. 9,310
-30.1% (March 15th)
-22.2% (March 7th)
-16.0% (March 4th)
-13.0% (March 1st)
Pfizer analysis had shown that unvaccinated individuals were 44 times more likely to develop symptomatic COVID-19 and 29 times more likely to die from COVID-19. Is there study if the remaining people being hospitalized for #covid19 in UK are unvaccinated? pfizer.com/news/press-rel…
On 2021 COVID-NET MMWR Wk 9 (From the CDC): 3.8 per 100k for COVID Hospitalizations.
On 2021 COVID-NET MMWR Wk 8: 4.3 per 100k for COVID Hospitalizations.
From 2019/2020 MMWR Wk 9: 4.4 per 100k for Influenza Hospitalizations.
From 2019/2020 MMWR Wk 8: 5.0 per 100k for
I see there is a circulating concern here that SARS-CoV-2 will mutate into a more virulent virus from vaccines. That is not what usually happens. The reason that #HIV researchers/physicians think about mutations/variants a lot is that HIV's polymerase journals.plos.org/plosbiology/ar…
has a very high mutation rate. SARS-CoV-2 and other coronaviruses on the other hand don't actually mutate that fast; their polymerase has a high fidelity to "proofreading" when they mutate. You just have been hearing about mutations lately in news. pubmed.ncbi.nlm.nih.gov/21593585/
HIV doctors think about mutations a lot because HIV mutates readily to evade medications we use commonly so we have to always think about how to combine medications for HIV to avoid or overcome those mutations. But mutations come with a cost to virus jvi.asm.org/content/81/6/3…