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Eric Feigl-Ding Profile picture
@DrEricDing
Mar 21, 2021 • 34 tweets • 19 min read • Read on X
PAY ATTENTION—There is one crisis we all needs to pay attention to—and that is the unprecedented Brazil 🇧🇷 surge of the #P1 variant, overloaded hospitals, & sharp mortality spike. If more contagious #P1 out of control worldwide, we are all endangered. 🧵

#SOSBrazil #COVID19 ImageImage
2) I cannot overemphasis how serious the crisis in Brazil is. It is virtually impossible to find any ICU bed, and many hospitals running out of sedative medications to perform intubation with—so doctors are intubating without any analgesic meds. Hospitals are in collapse.
3) I’m not exaggerating that hospitals in Brazil are in collapse. This is the headline of a major newspaper. Image
4) Don’t just listen to me. Listen to the reporting on the ground. This report was filed last week by @MattRiversCNN — he says it has gotten only worse.

5) Nobody can deny the pandemic when hospitals are completely overrun. Don’t let anyone dismiss #COVID19 and what is happening in Brazil - hospitalizations and deaths DO NOT LIE. Image
6) The crisis is described by the @fiocruz @fiocruz_en foundation as the **worst sanitation and hospital collapse in the history of Brazil** Image
7) I’m told by reporters that even “we're also hearing very consistently, that in Brazil more and more young people are dying on the virus. doctors keep telling us that their patients keep getting younger, no comorbidities” - from doctors across many cities. @MattRiversCNN
8) But also more concerning — Brazil experts analysis says P1 is potentially 2-2.5x faster transmission (more contagious) than the old common strains. That means it is also faster than #B117 sweeping the world.

We need to get serious about Brazil crisis. ?
9) Another Brazil research group puts #P1 transmission at 2x faster than old strain (instead of 2.5x above), but they estimate a way worse whopping 25-60% reinfection rate. That’s serious.

bbc.com/news/amp/healt… Image
10) How good is are the mRNA vaccines against this #P1 variant menace? Only semi— it has moderate neutralization- better than the SA #B1351, but worse than #B117 (which responds well to vaccine).

FYI earlier Pfizer-conducted study said okay, but this bigger study disagrees.
11) But the problem for Brazil is that it doesn’t have the mRNA vaccines. It has the AstraZeneca and SinoVac vaccine. We don’t know the exact efficacy yet for #P1, but SinoVac vaccine showed a much lower 50% efficacy in Brazil trials, before P1.

google.com/amp/s/www.bbc.…
12) Now 50% is still good, and for severe disease, it’s 78% for SinoVac, so that’s decent.

J&J vaccine shows mid to upper 80% for Brazil, but J&J isn’t available in Brazil yet either.

Main problem is Brazil doesn’t have enough! google.com/amp/s/amp.cnn.…
13) state of Rio de Janeiro suspended its vaccination campaign because it had run out of vaccine supplies.

"This is a disaster, a total disaster," a woman told CNN after being denied her vaccine. "Who is to blame for all this? I think our leaders, our politicians suck."
14) “less than 10 million people in the country of about 220 million had received at least one dose, according to federal health data. Only 1.57% of the population had been fully vaccinated.”

THIS IS AN EPIC DISASTER in the making for Brazil. google.com/amp/s/amp.cnn.…
15) How the hell did Brazil screw up its vaccine supply so much?

“multiple experts say the ineptitude of the federal government, led by Covid-skeptic Bolsonaro, has sabotaged. They point to a distinct lack of urgency on the fed govt to secure supplies”
cnn.com/2021/02/01/ame…
16) Brazil is in talks with the US to import some vaccines. The US already “loaned” 4 million doses to Mexico & Canada. But the talks with Brazil started March 13th and still have not reached any deal. Brazil needs it soon. Hope Bolsonaro is playing ball.
google.com/amp/s/www.voan…
17) Even with vaccine imports, and the delay in rollout and immunity kicking in, the next month will be brutal for Brazil. We might see what unmitigated full onslaught with a downplaying Bolsonaro looks like.

Meantime, Brazil ordering 3x the coffins.

metropoles.com/brasil/covid-a…
18) But I also want to offer a message of hope to the people of Brazil 🇧🇷— the world sees your struggle and your pain. I talk to colleagues at the WHO and in DC. The world has not forgotten you—even if your leader maybe sometimes has. The world needs to care and does care.
19) Meantime, Bolsonaro is the one person that world leaders need to call out and pressure. He is literally stopping all efforts to improve the situation. This is untenable.

If this Brazil crisis keeps going, I worry for its stability. google.com/amp/s/amp.cnn.… Image
20) I don’t believe in doomed fate. “There is no fate but what we make.”

Brazil needs help, Brazil needs change. Brazil needs leadership that will put human lives first, and to end suffering of its poor.

May God & the world help the people of Brazil.
21) To the rest of the 🌎—please don’t be selfishly withholding aid/vaccines. If Brazil’s #P1 crisis grows, so will the risk for the world. We rise as fall as one planet & civilization. We need to remember the motto—“All for one, one for all”—let’s all find our inner humanity. 🙏
22) p.s. the Oxford-AstraZeneca reported to be is efficacious against the #P1 variant. But the study hasn’t be released yet by researchers - details forthcoming.

US has a stockpile over over 30 million doses of AstraZeneca—it needs to release now.
cnbc.com/2021/03/05/oxf…
23) UK Imperial team:

⚠️“data show #P1 variant is 1.4-2.2 times more transmissible than other variants & original #SARSCoV2 strain, and 25%-65% more likely to evade existing protective immunity from previous non-P.1 infections—susceptible to reinfection.”
edition.cnn.com/world/live-new… Image
24) The catastrophe in Brazil is the worst in its history. And likely will be the worst in the annals of this pandemic — we desperately need to urgently send aid and vaccines to Brazil 🇧🇷.

Please help @WHCOS @aslavitt46 @ASlavitt @JeffZients @DrTedros @mvankerkhove @gabbystern
25) good news - vaccine deals inked by Brazil to buy more.

Bad news—most of the vaccines ordered aren’t coming for many many months.
26) Vaccine inequality is the great inequality that will lead to more tragedy in this pandemic.

We need to send vaccines urgently to Brazil, Mexico, and all of Latin America. #COVID19 #COVID19Vaccine

(HT @fibke) Image
27) The longer we neglect to vaccinate low and middle income countries (LMIC), the longer this crisis will continue.

#VaccinEquity for Brazil and all of Latin America and Africa and Asia.

(Ht @fibke)

pandem-ic.com/vaccine-equity… Image
28) ...I’m hearing some signals US might help Brazil hospitals in some potential ways soon. Unclear what yet. But there are some in WH that are exploring. Fingers crossed of what’s to come.
29) this was Brazil 3 days ago... and those spikes have now surged even more.
30) Now Brazil’s #P1 crisis has spilled over into neighboring countries...
31) And now #P1 has invaded North America - British Columbia 🇨🇦 has a recent sudden surge of #P1.
32) The Brazilian 🇧🇷 #P1 epidemic has now definitively spilled into other countries and caused outbreaks—the largest being in British Columbia, Canada.
33) P.s. small update on Brazil 🇧🇷 situation - I have receive word that Brazil is now engaging with the US directly. Hopeful 🙏
34) Brazil needs to act fast.... now more young people are dying than in first wave.

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More from @DrEricDing

Eric Feigl-Ding Profile picture
May 10
⚡️INBOUND SOLAR STORMS—5x mega coronal mass ejections - CMEs - that can knock out power are going to be slamming at Earth 🌍 between Friday and Sunday this weekend. Earth has only been hit with 3 previous severe CMEs in last 4 years. But we are gonna get 5x G4 CMEs in 3 days!😳 Image
2) Let this sink — this is the first GEOMAGNETIC STORM WATCH since 2005!

Folks - this is serious - it can knock out not only electricity but it can theoretically knock out airplanes ✈️ too! Image
3) Folks- it’s possible. Not only can it cause higher radiation and knock out communications, but a strong CME can knock out airliner avionics. “according to reports by aviation regulators, the issue is not whether it will happen, but when” 😳 thedailybeast.com/how-a-solar-st…


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Read 11 tweets
Eric Feigl-Ding Profile picture
May 10
⚠️New sudden outbreak of MERS coronavirus with HUMAN TO HUMAN transmission—WHO has put out an outbreak bulletin regarding 3 cases in Saudi Arabia 🇸🇦 who contracted MERS (with zero contact with camels). All 3 were hospitalized and intubated. Index case has died in just 11 days from the onset of cough and a runny nose. ➡️Here where it gets interesting—the other 2 cases, found via vigorous contact tracing—both likely contracted it from the index case in the hospital—one shared a hospital room with the index case, while the other merely visited the same hospital’s ER—but he was NOT in the same hospital ward as the index case! Given second case was in a completely separate ward of the hospital, it makes me think it was likely #airborne transmission.

Shouldn’t we all masking in hospitals? @CDCgov’s idiotic HICPAC committee that sets hospital safety standards meantime wants to water them down. Someone should share this with the HICPAC folks, thanks. And demand @CDCDirector to get serious about public health again.

who.int/emergencies/di…Image
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2) previously, WHO’s Feb bulletin of Aug 2023-Feb 2024 only reported 4 cases, 2 had camel🐪 contact. None of the previous 4 had any linkages (ie no human to human transmission evidence). Thus, this new hospital-derived outbreak is concerning.
who.int/emergencies/di…
3) it seems the Index case’s only overlap with Case #3 was on April 4th— the day they both went to the same hospital’s ER. But otherwise they were in different wards. And by the time the 3rd case went to the ICU on April 15th, the index case was already dead (died on April 11th). So it wasn’t ICU exposure. It was the ER—➡️why which why EVERYONE NEEDS TO WEAR MASKS IN THE ER DAMNIT! 🔥Image
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Read 4 tweets
Eric Feigl-Ding Profile picture
May 8
“Think of the impact [of #LongCovid] on inflation and economy. On the talented labor pool unable to work. LC is a terrible—in the U.S. so far—there’s been 16 million people, 4 mil out of a job—mostly young people in their 20s, 30s and 40s. Someone that used to jog 5 km can barely walk now because of permanent lung damage.“

(Moderna CEO Stephane Bancel)
2) Not just in the U.S… gee what happened to workers starting late 2020… the staggering loss of economic activity since the start of the pandemic is one of the biggest buried topics.
3) “One EU estimate suggests that long Covid may have cut labour supply in the bloc by up to 0.5 per cent in 2022, the equivalent of more than 1mn full-time workers. Studies in the US and UK have reached broadly similar conclusions — suggesting the condition has driven the recent increase in workplace absence in many countries”

ft.com/content/bb09a0…Image
Read 5 tweets
Eric Feigl-Ding Profile picture
May 6
Very worried—“The virus may soon develop the ability to transmit from one human to another… This is of great concern. Earlier birds… then it started affecting mammals and now the virus has evolved and developed the ability to infect humans…” @WHO Farrar
2) “We have to make sure that the H5N1 does not come across humans as it can easily develop the ability to transmit between humans.”
3) Last year, scientists warned of a key mutation that would help supercharge human transmission down the road — the critical “E627K” mutation in the virus’s RNA polymerase PB2 gene. ➡️Well, guess what effing appeared in a CDC report for the first time last month in an infected Texas man? ⚠️That very goddamn E627K mutation! This is mammalian adaptation. This is why WHO is warning we are maybe approaching the brink of human adaptation.

(Warning article about E627K from 2023).


(CDC report from April 2024).
science.org/content/articl…
cdc.gov/flu/avianflu/s…Image
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Read 7 tweets
Eric Feigl-Ding Profile picture
May 5
💔HEARTBREAKING—These twins need a $4.2 million one-time drug to save their lives (Spinal muscular atrophy). Their mother’s health insurance (and her employer) @Mosaic_LifeCare conveniently told the family the drug was cut from their coverage precisely one day after they were born. Total coincidence, my ass.

It’s also a race against the clock to get the treatment Zolgensma for the twins before it’s too late. If Zolgensma is given soon after birth, children may develop no significant disabilities. Children who receive the drug when they are a little older may avoid a feeding or breathing tube, and capable of some movement, rather than a life spent immobile, or death (<2 years usually), if not treated.

Zolgensma is sold by @Novartis. The drug sells for $1 million in Brazil, but $2.1 million in the U.S. Also in Brazil, if the child dies of SMA disease within 4 years, part of the $1 million payment is waived. But not in America. Many patients have had to sue health insurance to get the treatment covered—often at the expense of further disability of the untreated child.

All this is further enrage, when in fact, federally funded NIH research contributed to the development of Zolgensma. ➡️READ: Taxpayer dollars helped create the drug. Now the public is being shafted.



There is a GoFundme but this shouldn’t be the long term solution for other families. @Mosaic_LifeCare & @Novartis both need to be help accountable.


wbtv.com/2024/04/30/new…
gofundme.com/f/eli-easton-r…
durbin.senate.gov/newsroom/press…Image
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2) how can drug makers dare charge so much? Because they can - it is the only treatment and the only cure. I always remind people that healthcare is a NEED (like air and water) and not a “want” (like a fancy widget) If there is a monopoly, they can extort you if it’s a NEED.
3) Free market people will try to trick you into thinking it’s just the “supply and demand” / “free market” at work. But that’s only works for things in which there is no monopoly, and for things like iPhones and fancy gadgets “wants” that you can simply pass up if too costly. But if it’s a NEED—like lifesaving treatment—(eg you will pay anything to save your child / family member’s life)—then the supply & demand curve COMPLETELY BREAKS DOWN and is invalid. Big pharma and PBMs and your hospitals & health insurance premiums all exploit that in different ways. Don’t fall for “free market” bullshit that doesn’t apply to critical lifesaving healthcare.
Read 5 tweets
Eric Feigl-Ding Profile picture
May 2
Incredibly frustrating that the @USDA again failed to include basic information about H5N1 genetic sequences from cows. All data had dates and locations scrubbed out—only saying “USA” & “2024”, which is useless for scientists to analyze for mutation rates.
statnews.com/2024/05/02/bir…
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2) The fact that basic information — called metadata — isn’t being shared about the samples “hinders our efforts a lot,” said Gytis Dudas, a senior researcher in genomic epidemiology and metagenomics. Dudas is working with a group of U.S. and international researchers to try to make sense of what the genetic sequences say about the H5N1 outbreak in cows.
3) A number of scientists have openly questioned whether the USDA is deliberately withholding these data, or even removing more specific information. 🔥
Read 5 tweets

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