Thread by @DaveKeto

1/ For a very layperson-friendly video on conventional view of #LDL / #HDL #Cholesterol, and #ApoB, I highly recommend this one from @NutritionMadeS3

It's very visual and IMO fairly true to the more specific position of mainstream lipidology...

2/ Love his opening: "why is this topic so confusing? well, for starters scientists are horrible at coming up with names...there's LDL...and LDL cholesterol and they're different things....but a lot of people call them both LDL....and then there's HDL, VLDL..." (trails off)

3/ He's 100% right. It's why it's so hard to convert this for the lay audience. Lipidology could use a terminology upgrade.

For example, how did "Chylomicrons" manage to get a special exception to the "-DL" acronym party? (Only fellow lipophiles will get that joke... 😐)

4/ Anyway, he draws attention to looking at ApoB given existing med position is that both VLDL and LDL are atherogenic, and both are ApoB-containing lipoproteins.

Thus, higher ApoB, higher atherosclerosis, regardless of the VLDL/LDL proportions...

5/ #LeanMassHyperResponders (#LMHRs) typically have:

Very high #LDL-C, #LDL-P, and #ApoB (generally at 97%+ for the population)

However, they also typically have very low #VLDL-P and triglycerides, alongside high #HDL-C.

6/ Thus, @NutritionMadeS3 and others' position will be well tested with greater specificity in the #LMHRstudy

If very high #ApoB will result in rapid progression of atherosclerosis regardless of HDL and triglyceride levels, the CCTA data should provide powerful insight into this

7/ Thanks again for everyone's support in making this possible through the CitizenScienceFoundation.org.

We hope to have news soon once we're through IRB.