Good news—6 months results—Pfizer vaccine remains more than 91% effective against disease with any symptoms for six months. And it appeared to be so far good against the worrying #B1351 variant from South Africa in limited data so far. Thread 🧵 #COVID19
cnn.com/2021/04/01/hea…
2) "The vaccine was 100% effective against severe disease as defined by the U.S. Centers for Disease Control and Prevention (CDC), and 95.3% effective against severe COVID-19 as defined by the U.S. Food and Drug Administration (FDA)," Pfizer and BioNTech said”
3) "These data confirm the favorable efficacy and safety profile of our vaccine and position us to submit a Biologics License Application to the U.S. FDA," Albert Bourla, Pfizer's CEO, said in a statement. A BLA is an application for full approval—currently it has EUA.
4) “In South Africa, where the B.1.351 lineage is prevalent and 800 participants were enrolled, nine cases of COVID-19 were observed, all in the placebo group, indicating vaccine efficacy of ~100%”

My take — this is extremely early. I doubt it will stay like that. But hopeful.
5) "Vaccine safety has now been evaluated in more than 44,000 participants aged 16 years and older with more than 12,000 vaccinated participants having at least six months of follow-up after their second dose."

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More from @DrEricDing

3 Apr
Epidemiologist Dr. @larrybrilliant, who led smallpox global eradication, expressed concerns over new #SARSCoV2 variants and stressed need for a plan in addition to vaccines. “I’m quite worried—We seem to be getting variants of concern almost every week”.🧵
uk.news.yahoo.com/larry-brillian…
2) A coronavirus strain that originated in South Africa, for example, renders the AstraZeneca vaccine 90% ineffective, Brilliant pointed out. A variant first seen in Brazil can allow reinfection, and one that emerged in the United Kingdom is more transmissible.
3) “I do think we have to have a backup plan in addition to vaccinating everybody as fast as we can—get really much better at outbreak containment, detection, finding, isolating, & vaccinating them with the vaccine that matches the variant that our genomics tells us they have.”
Read 6 tweets
3 Apr
“ENVIRONMENTAL DISASTER” of phosphate factory 🏭 polluted water—32 million gallons per day are leaking out of a 800-million-gallon holding pool at industrial site near Tampa Bay prompted evacuation of residents within about a mile of the plant—worsening.🧵
axios.com/tampa-bay-mana… ImageImage
2) Florida Department of Environmental Protection said draining (the wastewater pools) was the only way to prevent "a containment failure and catastrophic release."
3) The wastewater pools at the now abandoned Piney Point fertilizer factory is long considered one of the “one of the biggest environmental threats in Florida history.”

floridaphoenix.com/2020/10/01/pho…
Read 10 tweets
3 Apr
I cry for the people of Brazil 🇧🇷

#P1 is serious. The world better wake up.

(HT @MaxCRoser & @OurWorldInData) #COVID19 Image
2) I tried my hardest to warn two weeks ago.

9 million people worldwide heard it.

Brazilian people heard it.

Biden WH heard it.

Brazil govt tried to ignore. But I’m told they’ve heard it.
3) now the more contagious #P1 is spilling all over the world.
Read 13 tweets
3 Apr
Outbreak in Vancouver Canucks hockey 🏒 team. “Privately, there is a lot of concern that medical evidence suggests more positive #COVID19 tests could follow. @NHL announced Canucks would not practise until at least Tuesday, nor play again until Thursday”🧵
sportsnet.ca/nhl/article/ri…
2) And also variant cases have been found among the Canucks hockey team outbreak.
3) As we know, Vancouver in British Columbia 🇨🇦 is the new epicenter of the largest #P1 variant outbreak outside of South America. P1 is very contagious.
Read 5 tweets
2 Apr
Update on AstraZeneca saga—UK has now found 30 clotting cases (22 of the specific kind found in Germany) out of 18.1 million AZ shots administered. That rate is 1:600,000 shots. This is very very low, but also 6x lower than the 1:100k found in 🇩🇪. #COVID19
reuters.com/article/us-hea…
2) also, in the UK report.... 0 cases of clotting found out of millions of Pfizer / BioNTech vaccines.

gov.uk/government/pub… Image
3) UK report emphasizes: “On the basis of this ongoing review, the benefits of the vaccines against COVID-19 continue to outweigh any risks and you should continue to get your vaccine when invited to do so.”
Read 5 tweets
2 Apr
Do vaccines lower transmission? YES, absolutely.

How much? By a lot—75% to 94% in recent studies.

Do vaccines completely eliminate any and all transmission? NO.

That is why we still need to mask after vaccinating until cases are very low or zero. #COVID19

(HT @MonicaGandhi9) Image
2) This was why I was fuming almost 3 days ago when I heard it. I asked @CDCDirector to retract, and last night she did.
3) Here’s details of @CDCDirector’s retraction. I’m glad she follows the science.
Read 7 tweets

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