Prepare for a thread about Well-formulated #Keto Adherence Paper that just came out.

Randomized crossover trial of 2x12-week #keto #LCHF vs. #Mediterranean diet.

Results show equally sustainable given the right conditions, but...
Researchers designed study that during first 4 weeks of each diet, food was provided & during the next 8 they had to buy their own. Baseline&followup adherence scores were also collected. All this allowed researchers to determine how sustainable diets were under diff conditions
baseline #keto adherence score was lower than Medi score. BUT during the time period when food was provided AND when they had to buy their own food, mean keto score was equal to or higher than Medi score. At the follow-up #keto score had dropped again. From this I conclude...
keto diet was not hard to adhere to itself, but social enviornment pushed ppl away from it b4&after study
In other words, not a diet issue but a social acceptability issue (at the population level)

Can see no difference (or a slight edge to keto) when food was made available.
Was also interesting to see some reasons individuals prefered one option over the other. IMO "better glucose numbers" is a better reason than "keto is for weight loss" / "I had no energy" (discouraged mineral supp during adapation), bc the latter 2 are misconceptions/misleading
Overall good study&both diets were strong-ish. Both <40% CHO reduced refined grains/ simple sugars. Chronometer was used to track food intake & ketone blood meters confirmed nutritional ketosis.

In Sum, keto is not a hard diet to which to adhere. It's our darn food ecosystem :(

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More from @nicknorwitz

26 Feb
nature.com/articles/s4159…
Some thoughts on why these results don't mean much to me
1/ It was 2 weeks, which is short term and not enough time for adaptation (see point 8 and others on this)

2/ "Both diets were low in ultra-processed food" is a misrepresentation....
...the low-carb diet was, IMO, unfairly weighted by processed foods and oils including mayo that I assume was made with soybean oil (correct me if I'm wrong), processed cheeses like "American cheese", and so on. It was also weighted towards meats and A1 dairy
3/LC diet appears far more palatable, and both diets were designed by the investigators, not freely chosen by the participants. If my snack options were unlimited roasted salted nuts sitting in front of me or dry edamame, apricots, and raisins, I'd eat more kCal of nuts too.
Read 8 tweets
23 Feb
Colleague and I had this RCT thrown in our face bc suggested a #ketogenicdiet option. Arguement was this RCT shows LCHF ⬆️LDL, therefore bad. Here's a thread about what I think...
(Spoiler, LCHF = good)...
1/ The LDL increase in the LCHF group may not itself be an adverse outcome. There was no subfractionation and it’s likely the increase in LDL and ApoB was driven by large fluffy healthy LDL particles. This assumption is supported an improvement in HDL levels in the LCHF group.
2/ HDL increased on the LCHF group, not the control group. When HDL is high and triglycerides are low, CVD risk is not meaningfully increased. See figure attached from Framingham. Furthermore, HDL (and waist circumference, below) are markers of metabolic syndrome. LDL is not.
Read 6 tweets
13 Dec 20
Today's FoD is being substitued by a thread of quotes from the below article
Explains how, in 1965, The Sugar Research Foundation (SRF)/Sugar Industry bought off scientists to promote sugar+demonize fats.
ncbi.nlm.nih.gov/pmc/articles/P…
A Must read
Cred to .@ProfTimNoakes lecture
The Sugar Research Foundation (SRF) became concerned with evidence showing that a low-fat [high-carb] diet high in sugar could elevate serum cholesterol level…
The SRF’s vice president and director of research, John Hickson, started closely monitoring the field…
Hickson proposed that the SRF “could embark on a major program” to counter “negative attitudes toward sugar.” …
In 1965, the SRF asked Fredrick Stare, chair of the Harvard University School of Public Health Nutrition Department to join its SRFs scientific advisory board
Read 11 tweets

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