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7 Apr, 5 tweets, 3 min read
The very rare brain blood cots—CVST—with the Astra Zeneca vaccine occur 50X more frequently than mRNA vaccines and are getting a lot of attention today, even before dueling press conferences of UK and EU regulators. Causality should not be in question.
The EU regulator's statement today asserting benefit of the AZ vaccine and that the CVST blood clots should be "listed as a very rare side effect of the vaccine"
ema.europa.eu/en/news/astraz…
As of April 4th, 169 cases of CVST and 53 splenic vein thromboses out of 34 million people vaccinated
Frequency ~1/100,000
And more in @kakape's thread
The UK regulator says people under 30 shouldn't get the AZ vaccine
wsj.com/articles/astra…
@MaximColch @DanMichaelsWSJ
But the evidence for any discrete age cutoff of risk in unclear
Graphic by @alex_freeman shows the UK calculation of benefit vs harm by age group

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More from @EricTopol

Eric Topol Profile picture
7 Apr
Best V3 news for today (vaccine-virus-variants)👍
1. Prior covid + mRNA vaccine (@BioNTech_Group) -> very high levels of neutralizing antibodies against B.1.351 (South Africa) and P.1 (Brazil) variants @NEJM (N=6)
nejm.org/?query=feature… Image
2. The mRNA vaccine (@moderna_tx) and @Novavax elicit high levels of neutralizing antibodies versus the B.1.429 (California) variant, similar to B.1.17 (UK) which means not very much immune evasion @NEJM nejm.org/doi/full/10.10… Image
3. Neutralizing antibodies against the B.1.351 (South African, 501Y.V2) variant cross-react to the others, telling us if we need a booster vaccine by incorporating this code, it should be quite effective (501Y.V3 = P.1, Brazil) @NEJM
nejm.org/doi/full/10.10… Image
Read 4 tweets
Eric Topol Profile picture
2 Apr
One of the world's leading virologists, @RobertoBurioni, added a new role 5 years ago—taking on anti-science. There's so much we can learn from him. Our conversation (and transcript) here, w/ @cuttingforstone @Medscape medscape.com/viewarticle/94…
We discussed the variants, vaccines, and, notably, their potential for blocking asymptomatic transmission. Lots of optimism (which we need!): Image
Why did he take on the role of dealing with science skeptics and the anti-vaxxers? Image
Read 4 tweets
Eric Topol Profile picture
2 Apr
What a good Friday!
First 4.0M vaccine day in the US
Hitting 4.0 M in a day gets the average now to 3.0M
bloomberg.com/graphics/covid…
CDC tally from this morning
Approaching 40% of adults, 75% of seniors, with at least 1 dose
This represents awesome progress
Read 4 tweets
Eric Topol Profile picture
1 Apr
Not exactly. You can be vaccinated and carry the virus (carrier). But if the viral load is so low you can't transmit (not a transmitter) spread is blocked and we move onto the pandemic exit ramp.
No transmitters, no 😷s
I think I explained it, @apoorva_nyc
nytimes.com/2021/04/01/hea…
Read 5 tweets
Eric Topol Profile picture
25 Mar
How to be a superhuman vs. #SARSCoV2?
Get vaccinated
Why do you become a superhuman?
1. Levels of neutralizing antibody for vaccine >> natural infection
2. Protection w/ vaccine additive to prior infection
3. Protection vs. variants: vaccine > natural immunity
4. Less reinfection
by @DennisRBurton and me @NatureMedicine nature.com/articles/s4159…
Read 6 tweets
Eric Topol Profile picture
24 Mar
How do you know that B.1.1.7 is dominant in Michigan?
When it has its highest number of new cases in a day in over 3 months
Image
Just as was seen in Israel, vaccination protection for older individuals with case and hospitalizations predominantly in younger, non-vaccinated. And reminder: the vaccines work very well vs B.1.1.7 freep.com/story/news/loc…
A big boost in vaccine distribution and support for administering mass vaccination in Michigan is warranted ImageImage
Read 4 tweets

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