Female patient presents with clinical symptoms consistent with pyelonephritis and her urine culture grows the following:
What is the mechanism of resistance of this E. cloacae?
Female patient presents with clinical symptoms consistent with a UTI and she has the following urine culture:
What is the mechanism of resistance of this E. coli?
Patient presented with fever and RUQ pain. He was found to have a liver abscess which has now been drained. Cultures grew the following:
What is the mechanism of resistance of this K. pneumoniae?
Pt presented w/abd pain & was found to have diverticulitis w/ abscess which was drained. Cx grew K. pneumoniae. Pt travels to India frequently.
Extended panel: Cefiderocol-S.
Exploratory: In vitro synergy of ceftazidime/avibactam and Aztreonam using Agar-Etest methods-S.
What is the mechanism of resistance of this K.pneumoniae?
Patient is in the ICU s/p MVA and is intubated for airway protection. He develops signs of pneumonia and a CXR shows alveolar infiltrates on the RLL. BAL culture grows the following Pseudomonas aeruginosa:
Which mechanism of resistance is likely expressed in this PSAR isolate?
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There are a four major types of gram-negative resistance mechanisms:
1.Enzymatic degradation
2.Change in binding site (e.g. MecA)
3.Loss of porin channels
4.Efflux pumps.
We will review here 1 and 3.
The most widely used classification of β-lactamases is the Ambler classification.
- Serine β-L vs. Metallo β-L
- A, B, C, D
See this brief commentary on the classification academic.oup.com/jac/article/55…
Hi #IDFellows and #IDTwitter, back with another case: 63F h/o ESRD on HD p/w fever. Blood cx positive for MSSA x 4 days. Blood cx clear on day 5 with Rx Cefazolin. TTE on HD2 without vegetations. What is the best next step?
1/ Let’s talk about when to get a TEE for Staph aureus bacteremia (SAB) to identify infective endocarditis (IE)!
We welcome Rookies (Anyone Pre-ID fellowship), Legends (those post-ID fellowship), and everything in between!
Participation includes the full game experience with questions, badges, and individual leaderboard.
Because this is a Fellows competition, you cannot join an individual team for the cup competition. But you can play as a large group (aka the bleachers).
We know is subjective & expect feedback/future improvements 👇
1. Clinical management of Staphylococcus aureus bacteremia: a review. pubmed.ncbi.nlm.nih.gov/25268440/
👉 A must read written by Holland et al. where they review the evidence of the management of SAB.
2. Impact of Infectious Disease Consultation on Quality of Care, Mortality, and Length of Stay in Staphylococcus aureus Bacteremia: Results From a Large Multicenter Cohort Study. pubmed.ncbi.nlm.nih.gov/25701854/
👉ID consult associated with reduced inpatient mortality.
1/ #IDTwitter and #IDFellows, here is another #IDboardreview question: 20F p/w pharyngitis w/fever. There is no cough. Exam: Cervical adenopathy; tonsillar exudate. Rapid Strep antigen test pos. You start to prescribe her Amoxicillin but there is an allergy alert.
2/ She reports an allergic reaction to penicillin around age 8 or 9. She had a rash but no other symptoms. It resolved following discontinuation of med. She did not receive any treatment. Which of the following would you do next?
3/ Today we are going to talk about everyone’s favorite – #penicillin#allergy!
1/ Follow up for our #IDFellows and #IDTwitter on an #IDCase - 25 year old female with behcet's disease and chronic pain who presents for positive T Spot done for screening. Started on Rifampin for latent TB Infection. She calls 3 days later with diffuse pain.
2/ Great job, #IDTwitter, honing in on the issue! This was intentionally vague to stimulate discussion. As you alluded to, the key lies in what else she was taking. But first, what might we worry about as adverse effects Rifampin?
3/ Allergic reactions to rifampin are relatively rare though they have been described. However, patients may experience flushing, rash and itching that is unrelated to hypersensitivity. Rifampin can often be continued in these patients. PMID: 10575418