EXCITING NEWS!

The @CovBoost clinical trial is open for registration of interest!

What is the @CovBoost trial you say?

Let me tell you!

CovBoost.org.uk

1/6
COV-Boost is a multi centre RCT for evaluating 3rd dose boosters against COVID-19

Which is most immunogenic?

Which have the best side effect profile?

Does it matter whether you had Pfizer or Oxford to start with?

We need to find out!

2/6
Who can take part?

We’re recruiting adults aged 30 and above who have had 2 doses of COVID-19 vaccine, with the first dose in January 2021 or in December 2020

If that’s you - please consider taking part!

CovBoost.org.uk

3/6
Participants will be randomised to receive a single dose of either a COVID-19 vaccine, a half dose of a COVID-19 vaccine, or a control vaccine (the meningococcal ACWY vaccine)

They won’t know what they received until the end of the study

4/6
There will be between 4 and 6 visits over the course of a year (depending on your group) with blood tests to check the immune response, including against variants of the SARS-CoV-2 virus!

5/6
For more info or to register your interest, visit the website at

covboost.org.uk

We have sites where you can take part all over the UK

The study starts very soon!

6/6

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More from @apsmunro

19 May
Not much time to tweet but this is important

Figures for hospitalisations and deaths for kids from COVID-19 should be treated with *extreme caution*

Incidental positive tests make up a big proportion - up to 40% in data from California

nymag.com/intelligencer/…

1/4
Remember the paediatric wards in London supposedly filling up with children with COVID-19 last autumn?

Not only were they not very sick, a full 33% of them were admitted for something unrelated to COVID-19

They just happened to test positive

doi.org/10.1016/S2352-…

2/4
Reports are of 600 child deaths from COVID-19 in the US, but no clarification of how many children died WITH COVID-19, or FROM COVID-19 (unlike adults, this is a big issue for kids data)

NB: The CDC estimates ~600 child deaths from flu annually

cdc.gov/flu/spotlights…

3/4
Read 4 tweets
4 May
Three great new studies of COVID in children this week!

First, household transmission in Germany 🇩🇪

Contacts of PCR pos cases tested Serology

Children both less susceptible AND less infectious when index cases than adults

journalofinfection.com/article/S0163-…

1/4
Next COVID in children from in Hong Kong 🇭🇰

>300 children positive, only 3 cases acquired in School and all the rest in the household or from travel

jamanetwork.com/journals/jaman…

2/4
Finally, a household contact study from Israel 🇮🇱

Contacts tested with both PCR AND Serology (subset)

Children about half as susceptible to adults and nearly half as infectious

journals.plos.org/ploscompbiol/a…

3/4
Read 4 tweets
19 Mar
Great @bmj_latest study from OpenSAFELY

Despite schools being the only thing open for much of wave 2 in the UK, living w/ children associated with marginal increased absolute risk of COVID-19 infection/hospitalisation, and no increase in death

bmj.com/content/372/bm…

1/7
The study compared hospital records of over 9mil adults <65yrs during wave 1 and wave 2, comparing those who lived with children (split by primary and secondary age) to those who don't

They adjusted for covariates such as deprivation, age, BMI, smoking, etc

2/7
Wave 1: No difference in outcomes, except much lower risk of death for people with children

Wave 2: Tiny increase risk in infection and hospitalisation for those living with children (smaller for young children), but same or lower risk of death from COVID-19 or any cause.

3/7
Read 7 tweets
11 Mar
The #SARSCoV2 variant b.1.1.7 is taking over

But is this variant especially scary in children? ☠️

Are they suddenly driving infections? 🚗

Is this quadruple worrisome? 😱🚨⚠️

Let's take a look at the evidence

1
b.1.1.7 became of concern initially following a surge of cases in SE England after autumn lockdown

Case trends in children had previously lagged adults by a week or so (because adults drive infection rates), but this surge happened near simultaneously

doi.org/10.1016/j.jinf…

2
Some scientists leaked to the press of "hints" that there was something unique to children about this variant

This was based on an increased share of b.1.1.7 cases in children compared to adults during the late Autumn

doi.org/10.1101/2020.1…

3
Read 16 tweets
18 Feb
I have seen some repeated assertions about the evidence on #COVID19, children and schools recently which sound convincing, but unfortunately are false

It is a sensitive and important topic, which is important to get right

Shall we bust some myths? 💥

Let's go!

1/10
Myth 1. Evidence suggesting limited transmission within schools is based on flawed evidence as only children with symptoms were tested ❌

There are many studies drawn on symptom based testing, there are MANY which are not, and all find the same thing

Here's just a few...

2/10
Read 12 tweets
5 Feb
You may have seen this headline today

It may even have been accompanied by scary emojis ⚠️ 🚨 💥 😱

The reality is much less scary (as is the article compared to the headline)

1/4

theguardian.com/world/2021/feb…
These numbers are roughly accurate, but do not reflect anything like a comparable scenario to spring

These children are MUCH less unwell, due to a combination of recognising less severe cases, early management, and perhaps a degree of over diagnosis to be on the safe side

2/4
Only a couple of patients per day are even unwell enough to be enrolled in the worlds only clinical trial for this condition, the RECOVERY trial

Very few cases of coronary artery aneurysms, which even after spring resolved for most children over follow up

3/4
Read 4 tweets

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