1️⃣lets not torture our patients with more Lactulose if they don’t need
2️⃣cog function *as we measure it* does not matter but QOL, functioning/PROs, risk of overt HE do - let’s study them
3️⃣develop stool/blood/PRO biomarkers of Lactulose response
And.... I forgot to tag @JasmohanBajaj, senior author, who consistently fosters revolutions in how we think about and manage hepatic encephalopathy
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2/
Wrong: You'll have "all the resources you need"
What are these? Stats, research cores, coordinator pools...
These are...people!
You cant promise a person!
Right: Meet X, 25% of their effort will be directed towards your work if you gel. Or here is $$$ to hire Y.
3/ Wrong: we expect you to do research, quality, etc
Right: we will support your research for X years
The week is 10 1/2 day sessions. Anything not clinical needs protection. 7 sessions is 30% protected. I was protected 3 years by the dept
Then I needed a grant for protection
It’s an enzyme that transfers amino acids to proteins. It's found anywhere things need transferring (liver cells, bile ducts, kidneys, heart....)
No big deal, right?
Wrong!
3/
It did not take long to figure out that while lots of conditions raised the GGT, liver disease and biliary obstruction were the best at making high GGT
First, I have mentors to thank. Dr Michelle Lai who gave me my start and launched me. @SenguptaNeil who taught me everything I know. And the reason I moved my family from Boston to a suburb of Detroit known away from good food, Dr Lok, the greatest mentor I will ever know
Second, I have advice. Find a place where you are surrounded by greatness and absorb it. It has been the great fortune of my life to work alongside and learn from people like JMellinger, @AkbarWaljee, and above all @NDP1001