Here's something fun and different for Toxicology Thursday: a self-guided poison plant tour at @ncartmuseum. Admittedly, it's centered around Raleigh-Durham folks, but these plants can be found throughout the southeast and other parts of North America. [link to PDF at the end]
Starting at the main lot, we'll walk down into the open clearing to find POKEWEED. The berries are poisonous and will stain your hands. Mature plants are poisonous too, but small young ones used to be sold in cans.
You'll also find (unless the groundskeepers recently mowed over everything) CAROLINA HORSENETTLE. It's like a tiny, prickly tomato, but it's not edible. All parts contain solanine and are toxic.
There's also occasionally MORNING GLORY climbing its way over everything. It contains lysergic acid amide, a precursor to trippin' LSD. Don't eat the plants or the seeds, please.
Once you enter the woods, you'll find POISON IVY everywhere. Huge vines on trees, as big as your arms. Remember - Leaves of three, let it be.
Take the left up the hill on the dirt trail, and you'll see WILD GINGER. This isn't edible, but it is pretty. Eating it will wreck your kidneys - it's nephrotoxic due to aristocholic acid.
On the damp, shady soils you'll find my favorite: BLOODROOT. It only flowers in the early spring (March around here), and it's so delicate and pretty. The root exudes a red latex with sanguinarine, the DNA killer. It's bad. Don't use 'black salve' as a cancer remedy.
Also in the woods, and elsewhere, you'll find another favorite, SASSAFRAS. It's a spindly, scrawny tree in these parts, but its leaves, when dried, give us file powder for gumbo and its roots used to be used for root beer. Used to, because of safrole and bad science.
Along the paved trails, near the ditches, you can find WATER HEMLOCK, a relative of the poison hemlock that killed Socrates. This is poisonous, too, with violent seizures and death from respiratory paralysis. It's easily confused by amateurs for wild carrots. Don't eat it.
At the outdoor exhibit, near the walls with plaques of famous quotes, you'll find CAROLINA JESSAMINE. It's so pretty and found throughout the Carolinas, but it's poisonous due to gelsemine, a glycine receptor agonist. Arthur Conan Doyle once poisoned himself on purpose!
And that concludes the virtual tour. If you haven't been to the museum and trails, you should. It's a great way to spend your day. I gave this tour to a friend's Girl Scout troop. We all had a great time! The link to the PDF can be found on my site, here: naturespoisons.com/poisons-in-the…
I should add: The walking route in red is about 1.5 miles and mostly paved, but some parts are on compact dirt trails. For reference, the 'blue trail loop' you see on the map is 1.0 miles.

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More from @NaturesPoisons

14 Jan
It's Thursday and time for toxicology, so enough politics, let's talk poisons (I think I need this more than you!). Today it's all about one of our favorite condiments, HORERADISH. It may seem simple, but its pungency is due to a binary weapon!
So that's horseradish growing in my garden, in case you were wondering where it actually came from. It goes amazingly well and the young leaves are edible - they add a nice little kick to a sandwich.
But horseradish sauce doesn't come from leaves, it's made from horseradish roots, like these that I harvested:
Read 15 tweets
26 Nov 20
Happy Thanksgiving to those of you in the US! Happy Thursday to the rest of y'all.

I told you these were coming during my #amwriting breaks! In the spirit of overeating and edible things, here's the toxic tale of COPRINE.
The inkcap mushrooms, or "inky caps", are edible mushrooms with a mild flavor. I know, you're here for the poisonous mushrooms, not the edible ones. It is edible, but not when you consume them with alcohol! Weird, I know, but I'll explain. [pic by Nick Saltmarsh (CC BY-2.0)]
The ink caps contain a chemical called COPRINE. It's not too special, though the cyclopropyl group (the triangle part) is always fun to see in natural products. The problem with COPRINE is when it is metabolized. When ingested, the body breaks it down to AMINOCYCLOPROPANOL.
Read 11 tweets
25 Nov 20
As promised, more toxic tales as I take a break from #amwriting. What I love about poisons is where it takes you: chemistry, biology, history... maybe the ED or a shallow grave.

Today we'll talk about the neurotoxic, hiccup-inducing, destroyer of kidneys CARAMBOXIN.
Caramboxin is found in starfruit, the fruit that is, uh, shaped like stars. It grows throughout Southeast Asia and tastes like a citrusy apple to me. It's a unique flavor and I rather like it. [pic by Ting W. Chang (CC BY-2.0)]
But you don't want to eat too much of it. I already spoiled it - I'm rightfully accused of being too "telly" in my writing - because of caramboxin.

Caramboxin is a non-proteinogenic amino acid - it's not encoded into our DNA or needed for anything. It's strictly a poison.
Read 13 tweets
24 Nov 20
I have the rest of the week off, so when I take a break from #amwriting, expect a bunch of these.

You've heard of capsaicin, right? The the "hot" chemical in chili peppers? Today I present you with RESINIFERATOXIN. It's 🔥🔥🔥!
The resin spurge plant, Euphorbia resinifera is a cactus-y type thing found in north Africa. If you cut it open, it exudes a milky latex that contains resiniferatoxin. But watch out! [Pic by James Steakley (CC BY-SA 3.0)]
Resiniferatoxin is about 1000-times "hotter" than capsaicin. It's likely the hottest, most painful toxin on the planet, so I advise not putting it in your chili or making a hot sauce out of it.
Read 9 tweets
26 Aug 20
*Internal screaming*

Every reputable and credible forensic pathologist and toxicologist has issues with this "reporting."

A thread, as the kids say.
First, forensic toxicology, or any part of a medico-legal death investigation, can not be done in a vacuum. I made this for death investigation talks. It's like the fire triangle: heat, fuel, air. To determine a cause of death we need: Investigation, Pathology, and Toxicology.
Second, yes, George Floyd had illicit fentanyl in his blood (the methamphetamine is so trivial a lot of labs wouldn't even bother confirming or reporting it). No one is disputing this, nor should they.

Was it fatal? LOL, no. He was walking and talking not dead on a couch.
Read 13 tweets
6 Jun 19
It's Toxicology Thursday!
Let's talk about Tinyatoxin. It's got a funny name, which is why I chose it, but there's nothing tiny about the pain it produces...it brings the heat, literally.
On the chemistry side of things, it's got a super weird structure. That tri-phenoxyethyl ether thingy is odd (that's the top part, with the three oxygens (O's) I'm talking about). I don't know if I've seen a structure with one of those before, and I've seen a lot of structures.
On the botany side, tinyatoxin is produced in the succulent plant Euphorbia poissonii, which is native to Nigeria and west Africa. If you cut it open it exudes a milky latex that contains, you guessed it, tinyatoxin.
Read 13 tweets

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