Share this page!

Priya Sampathkumar Profile picture
Twitter logo
11 Jun, 7 tweets, 5 min read
Just out: Study of 10,567 health care workers in India @OffCMCVellore

2 doses of COVISHIELD (Astra Zeneca) was 94% protective against need for ICU care. 77% protection from hospitalization.

#VaccinesWork #GetVaccinated @GKangInd @DrEricDing @MayoProceedings
2/ This study was done between Feb - May 2021. No deaths were seen in 8958 vaccinated healthcare workers. One death in 1609 unvaccinated healthcare workers.
3/ Protection began even after first dose. Single dose provided 95% protection from ICU admission. However, note that we don't know what proportion of cases @OffCMCVellore were due to B.1.617.2 (delta variant) or B.1.617.1 variant or wild type.
4/ UK study showed 88% protection from symptomatic COVID against delta variant with 2 doses of Pfizer; 66% with Astra Zeneca vaccine. With 1 dose, protection was 33%. This study is specific to delta variant, & endpoint was symptomatic COVID. Not ICU care. khub.net/documents/1359…
Link to full paper from @OffCMCVellore @MayoProceedings

…s-jbs-prod-cdn.jbs.elsevierhealth.com/pb/assets/raw/…
Congrats to the authors on this important study. @joy_mammen @OffCMCVellore #JVPeter

#GetVaccinated
Note that the paper from @OffCMCVellore is not a preprint. It has been published in @MayoProceedings (the Journal posts articles online ahead of print when important).

mayoclinicproceedings.org

• • •

Missing some Tweet in this thread? You can try to force a refresh
　

Keep Current with Priya Sampathkumar

Priya Sampathkumar Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @PSampathkumarMD

Priya Sampathkumar Profile picture
14 May
1/ 🧵on Mucormycosis (Black fungus)

COVID associated Mucor is increasingly being reported in India.

Spores of fungi are common in the environment. Infection occurs when circumstances are right.
Immunosuppression and uncontrolled diabetes are main culprits
2/ Spores of mucor are breathed in and cause infection

Risk factors

- Prolonged/high dose steroids suppress the immune system and elevate blood sugars, which further increase risk

- uncontrolled diabetes

- Widespread antibiotics may contribute via overgrowth of fungi
3/ Two main forms of post Covid mucor: rhinocerebral and pulmonary.

In one case series:
- 95% of pts had diabetes, mean HbA1C was 10.5

- Onset at median of 22 days after onset of Covid symptoms

- Only 5% occurred after mild Covid
Read 7 tweets
Priya Sampathkumar Profile picture
13 May
Vaccine hesitancy: My responses to the main concerns.

1) Vaccines were developed too fast.

Although developed at warp speed, none of the essential steps were skipped. The huge number of cases made accrual to trials much faster
2. Vaccines are not effective

In large trials, vaccines were 80-95% effective at preventing infection. They are even more effective at preventing hospitalization and death
Yes. They are not perfect, but are highly effective. Real world data confirms data from clinical trials.
3. Vaccines are not safe:

There is a small risk of severe allergic reactions (1 in 1 million for mRNA vaccines). There is a small risk of severe blood clots with J& J (1 in 500,000). Other side-effects are mild. Risk of serious side effects is small compared to risk from COVID
Read 9 tweets
Priya Sampathkumar Profile picture
26 Apr
Tips for managing COVID at home. Infographics in English & multiple Indian languages with more coming ⁦@VincentRK⁩ ⁦@nramind⁩ ⁦@ShirleySetia⁩ ⁦⁦@iamsrk⁩ ⁦@VijaySethuOffl⁩ #covidindia. Please retweet and amplify indiacovidsos.org/home-care
How to manage COVID at home. English version. Image
कैसे घर पर कोविद का प्रबंधन करने के लिए
हिंदी संस्करण Image
Read 15 tweets
Priya Sampathkumar Profile picture
21 Apr
I am getting calls from friends/ family in India about COVID. From neurosurgeons to urologists, doctors are being roped in to handle the crisis.

1/ Having managed pts with COVID for the last year & having the luxury of time, here are my thoughts for those new to this battle.
2/ Diagnosed COVID? What next ?

Check oxygen sats.
If sats > 90%, reassure
-Paracetamol as needed for fever
-Inhaled steroids (budesonide)
-Continue to follow sats
-No need for hospitalization
-No need for chest CT
3/ if O2 Sats < 90%

-Supplemental oxygen
-Dexamethasone 6 mg/day or equivalent steroid (prednisone 40 mg, methylprednisolone 30 mg; hydrocortisone 150 mg
Steroid preparation/route does not make a difference
-Prone positioning ( sleeping on stomach)
Read 7 tweets
Priya Sampathkumar Profile picture
17 Mar
Astra Zeneca vaccine has been paused in many European countries due to concerns about blood clots. What do we know. What does this mean?

1/ 17 million doses in UK and EU - To date 15 cases of deep vein thrombosis & 22 cases of pulmonary embolism. Rate is not higher than expected
2/However cases of blood clots veins in the brain, called central venous sinus thrombosis have been reported. These are very rare occurrences and this is concerning
3/ So far Denmark, Norway, Bulgaria, Iceland, France, Germany, Italy, Spain, Portugal, Slovenia, and Cyprus have suspended all use of the vaccine. Five other countries (Austria, Estonia, Latvia, Lithuania, and Luxembourg) have paused the use of a single batch of the vaccine.
Read 10 tweets
Priya Sampathkumar Profile picture
15 Mar
COVID outcomes at Mayo Clinic.

1/ Outcomes in 7217 adults and 674 children published in @MayoProceedings

2/ In adults:
897 of 7217 (12%) needed hospitalization

354 of 7217 (5%) needed ICU

94 of 7217 (1.3%) died

@MayoClinic @MayoClinicINFD mayoclinicproceedings.org/article/S0025-… Image
3/ Risk of hospitalization by age:

<18: 2%
18-34: 3.5%
35-49: 10%
50-64: 18%
65-74: 30%
>=75: 46% Image
4/ Risk of needing ICU admission by age:

<18: 0.3%
18-34: 1%
35-49: 4%
50-64: 8%
65-74: 13%
>=75: 16%
Read 8 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!

Like this author's thread?

Get emails when @PSampathkumarMD has new unrolls!

Check out other threads from @PSampathkumarMD!

Read all threads by @PSampathkumarMD

:(