What a pleasure to hear @NHLBI_Translate from @nih_nhlbi talk @YaleCardiology about the persistent gaps in quality of healthcare and the opportunities with implementation science. He is challenging us to do more with what we already know works. @YaleMed@NIHDirector
@NHLBI_Translate@nih_nhlbi@YaleCardiology@YaleMed@NIHDirector For context…implementation science is the study of methods to promote the integration of reserach findings and evidence into healthcare policy and practice. [and we must involve patients in all of these efforts].
Also from @NHLBI_Translate … “We need strategies for rapid integration of proven-effective interventions into routine clinical practice and health policy.”
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“...first longitudinal imaging study in #COVID19 where patients initially scanned before contracted the disease.” An incredibly important @uk_biobank study… 'Brain imaging before and after COVID-19 in UK Biobank’ by an esteemed group. medrxiv.org/content/10.110…@medrxivpreprint
@uk_biobank@medrxivpreprint "significant, deleterious impact of COVID-19 on olfactory & gustatory cortical systems, w/more pronounced reduction of grey matter thickness & volume in L parahippocampal gyrus, L superior (dorsal) insula andL lateral orbitofrontal cortex in COVID patients.” #LongCovid
@uk_biobank@medrxivpreprint Here is the kicker… of the people w/COVID for whom there are records, very few had been hospitalized. These brain effects occurred largely in largely in people not sick enough to be hospitalized. Time to re-think how benign this is in people w/o severe symptoms. Time will tell.
@PeterHorby@MartinLandray@medrxivpreprint They studied @Regeneron monoclonal antibodies (casirivimab and imdevimab). They report: 'In patients hospitalised with COVID-19, the monoclonal antibody combination ... reduced 28-day mortality among patients who were seronegative at baseline.'
@PeterHorby@MartinLandray@medrxivpreprint@Regeneron An important finding in this trial is that the effect of the monoclonal antibodies was present in hospitalized patients with COVID-19 who were seronegative, but not those who were seropositive. A key insight into who benefits.
@NatalieJLambert@medrxivpreprint "Symptoms causing greatest distress (scale 1 “none” to 5 “great deal”) were extreme pressure at base of head (4.4), syncope (4.3), sharp or sudden chest pain (4.2), brain pressure (4.2), headache (4.2), persistent chest pain or pressure (4.1), and bone pain in extremities (4.1)."
@NatalieJLambert@medrxivpreprint Again, we see a remarkable range of downstream symptoms from COVID; this illness has devastating consequences for so many that extends far beyond the acute illness. Much to learn. Need to move quickly. @Survivor_Corps@dianaberrent
Worth your time to take a look at @EdwardTufte new book: Seeing with Fresh Eyes: Meaning, Space, Data, Truth. He is a visionary warrior fighting for clarity in visual communication. Has always inspired me. edwardtufte.com/tufte/seeing-w…
@EdwardTufte From @EdwardTufte: “Conventions (We’ve always done it this way) enshired in leagacy code caused 50 years of content-hostile and reader-inconvenient data graphics in powerpoint, excel, and sophisticated data-analysis computer packages."
@EdwardTufte From @EdwardTufte: ‘Electronic health records seize ownership of medical information. Medical center business plans = own the data, own the patient.’ ‘Medical centers…intimidate patients to sign gag orders seizing ownership of all records.' @ePatientDave@TheLizArmy@myopennotes