Thread by @DaveKeto

1/ I'd like to put a lot of misconceptions to bed on this topic -- so let's unpack...

I personally believe the coming #LMHRstudy will be neither one of these:

1) A categorical end to the lipid hypothesis
2) Completely meaningless

https://twitter.com/DrNadolsky/status/1410689028102397954

2/ If it seems like there's a wide spectrum of possibilities between those two endpoints, it's because there is

Sure, I do think this may end up testing if the lipid hypothesis can be taken as "dose-dependent, log-linear" in every context. But that's not testing it categorically

3/ For example, it could well be we observe a very low progression of plaque in LMHRs for reasons none of us are aware of yet, but of which don't apply to those with atherogenic dyslipidema in original sense (thus, mixed outcome, new mechanistic aspects yet to be determined, etc)

4/ Or it could be we observe very rapid progression of plaque this data could have a broad impact across the low carb community to take steps in reducing LDL. (Which is why LDL-lowering proponents should want this study most given LMHRs' unique standing to isolate specificity)

5/ But likewise, this will be meaningful data to a lot of people who are LMHR phenotypes, without question.

It shouldn't be taken by anyone as the definitive study (I'm sure my colleague, @DrNadolsky would agree strongly on this).

And feel free to quote me on this as well.

6/ All that said, the research is truly overdue. Before crowdfunding this, I put forth a lot of effort going through typical channels before finally giving up. And I'm proud to say the Low Carb community stepped up to make this a reality (many funders are themselves LMHRs)

7/ In the mean time, should you assume we know the LMHR phenotype is perfectly safe? No -- we don't know that -- it's why we're doing the study.

As always, I want everyone following my work to follow those of opposing opinion as well. Research, learn for yourself.

8/ When I say I'm "cautiously optimistic" regarding lipid changes and the triad (⬆️LDL+⬆️HDL+⬇️TG) as related to metabolic fat-adaptation, the operative word is "cautious" (as opposed to "not cautious")

Here's 13, 14, and 15 of my pinned tweet as a refresher for consideration

9/ Lastly, and perhaps most importantly, if you're pro-lipid hypothesis, please give credit to @DrNadolsky as an investigator for his efforts in helping us craft this study. If you look through his social media, you'll find he's a strong fan of keeping LDL/ApoB substantially low.

10/ And while I can't know/reveal what the details will be until we're through IRB, I can say entire team is quite adamant about releasing as much direct data as we can to everyone, so the ability of any of us on the team to spin it internally is very limited in the first place.

11/ I'm sure they'll still be some on both sides of this issue that have different opinions on what this study means than we do, but for those wanting better clarification -- hopefully this helped.