1/ Great thread by @nicknorwitz
Yes, we started talking about this paper as I stumbled in it while looking up citations for a project we’re doing (more on that later)
Per my recent talks/threads, I think successful LPL activity (emphasis on “successful”) is key with triad/LMHRs
Yes, we started talking about this paper as I stumbled in it while looking up citations for a project we’re doing (more on that later)
Per my recent talks/threads, I think successful LPL activity (emphasis on “successful”) is key with triad/LMHRs
https://twitter.com/nicknorwitz/status/1412359620694364166
2/ But I had no idea there could actually be such a direct pathway to Acetate/Acetoacetate (AcAc) and LPL expression- being crucial for accessing fat stores. While this paper is a mouse model, it’s results are quite impressive when looking to knockout of GRP43 (GRP4-/-) vs normal
3/ and while Nick’s thread importantly mentions the fact these knockout mice *gained* weight on the ketogenic diet — I think a likewise incredible finding is that they also demonstrated far more difficulty in losing weight when eating nothing at all (fasting) 
4/ But also note what happen with energy expenditure by comparison over that same period of fasting — the GRP43-/- mice drop lower than controls. Reduced weight loss coupled with reduced expenditure.
5/ Needless to say, I think we consider this a potentially powerful piece to the puzzle, particularly with regard to direct ketone signaling and fatty acid release and overall homeostasis in both fasting and a ketogenic diet.
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