Thread by @EduEngineer

1. The story that the unvaccinated are "Variant Factories" is a lie that must be answered.

Technically, every infected individual is a variant factory, but such a statement is misleading in the extreme...

2. Point mutations occur at random in viruses, all the time, constantly. Most mutations either result in nonviable progeny, or progeny that is no more (and potentially less) harmful. That's > 99.99999% of such progeny.

3. So, it does not matter that there is greater diversity among surviving mutated strains among the unvaccinated. According to Muller's ratchet, selection continues to less harmful survivors, no matter how diverse.

4. What matters is that the result of vaccination is a screening process for progeny---a sieve! The process of passing through the sieve selects specifically for those mutations that evade defenses. By definition!

(Sorry for my bad art)

5. This means that the vaccinated are "factories that select for immune evasion", while the unvaccinated are "factories of random, mostly nonsensical, but diverse mutations that almost always die out quickly while crowding out those that might evade mutation"!

6. The greatest risk is a variant that evades evasion, carrying with it spike protein in a form not specific enough for existing antibodies to recognize, then potentially to be enhanced in interaction. This tempts the ADE result we hope not to see.

@MonicaGandhi9

*evades immunity (not evades evasion, heh)

7. I wrote a more complete argument on the topic.

roundingtheearth.substack.com/p/variant-roul…