Today was a really important step forward in work to better understand the origins of #SARSCoV2 & for the emergence of all future novel pathogens of epidemic & pandemic potential…
“Earlier this week, Member States received a circular letter detailing the proposed next steps that the (@WHO) Secretariat will take to advance those studies, in several areas…
“1️⃣ integrated studies of humans, wildlife, captive and farmed animals, and environment, as part of a #OneHealth approach;
“2️⃣ studies prioritizing geographic areas with the earliest indication of circulation of #SARSCoV2, and neighbouring areas where other SARS-related CoV have been found in non-human reservoirs;
3️⃣studies of animal markets in and around Wuhan, incl continuing studies on animals sold at the Huanan wholesale market;
4️⃣ studies related to animal trace-back activities, with additional epidemiology and molecular epidemiology work, including early sequences of the virus;
“5️⃣ audits of relevant laboratories and research institutions operating in the area of the initial human cases identified in December 2019.
“…Finding where this virus came from is essential not just for understanding how the pandemic started & preventing future outbreaks, but it’s also impt as an obligation to the families of the 4 million people who have lost someone they love, & the millions who have suffered
“… (NEW) @WHO is establishing a permanent International Scientific Advisory Group for Origins of Novel Pathogens (SAGO)…
SAGO will play a vital role in the next phase of studies into the origins of #SARSCoV2, as well as the origins of future new pathogens…”
Now from me… this is a big deal. This framework will define, guide and implement a process to study future emergence or re-emergence of outbreak/epidemic/pandemic pathogens.
As I have said so many times and will continue to say… we are so grateful to our member states, to our expert networks, to our partners, to @WHOGOARN, to those who go on @who missions (many of which I’ve been on as @WHO & as an external partner) …& to science.
Science needs to guide the way. It must.
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Statement on the eighth meeting of the International Health Regulations #IHR (2005) Emergency Committee regarding the coronavirus disease (#COVID19) pandemic @WHO
The @WHO secretariat highlighted factors driving the current situation including:
➡️variants of concern,
➡️inconsistent application of public health & social measures,
➡️increased social mixing & mobility, &
➡️highly susceptible pop due to lack of equitable vaccine distribution
“The Committee noted that, despite national, regional, and global efforts, the pandemic is nowhere near finished. The pandemic continues to evolve with four variants of concern dominating global epidemiology….
I’m struggling with how best to stress how fragile the global situation is, so I’ll be blunt:
Each week >2.6 million cases and >53,000 deaths are reported to @WHO
Reported, meaning that there are many others.
Stop and think about that.
(Short thread⬇️)
Compared to last week, there has been about (exact % will be shared in tomorrow @WHO sit rep):
➡️ 15% increases in cases in @WHOAFRO
➡️ 29% increase in @WHO_Europe (last week was 10%⬆️)
➡️ 14% increase in @WHOEMRO
➡️ 7% increased in @WHOSEARO
➡️ 10% increase in @WHOWPRO
Conclusions: Rapid replacement means that epidemiological assessment of new variants must be conducted quickly and regularly if PHSM are to continue to reduce the spread of SARS-CoV-2.
Given limitations and inherent delays in detecting emerging variants and investigating their phenotypic impacts, the use and adjustment of PHSM should continue to be informed by traditional epidemiological surveillance.
There is a lot of concern over the Delta (B.1.617.2) variant and there should be. The #SARSCoV2 virus is dangerous, & more transmissible variants are even more dangerous.
What we know: available analyses show that there is increased transmissibility of delta, more than the ancestral virus, more than alpha variant. We are seeing convergent evolution.
There is a suggestion of increased severity, but more info is needed to understand this.
Diagnostics work; many studies are underway related to vaccines, but available results suggest vaccines work against severe disease & death.
The labels for VOI/VOC are simple, easy to say & remember & are based on the Greek alphabet, a system that was chosen following wide consultation & a review of several potential systems.
The labels don’t replace existing scientific names, which convey impt scientific info and will continue to be used in research (& by @nextstrain@GISAID & Pango).
These labels will help with public discussion about VOC/VOI as the numbering system can be difficult to follow.
We expect that more variants will continue to be detected as the virus circulates and evolves and as sequencing capacities are enhanced worldwide.
It’s even more critical we drive down and keep down transmission. @WHO#COVID19
As we have said, each variant identified needs to be properly assessed, which is why WHO established the Virus Evolution Working Group in June 2020, and why there is a Global Monitoring and Assessment Framework for #SARSCoV2 variants, coordinated by @WHO.
Re the report of variant from Vietnam: @WHO 🇻🇳 country office & @WHOWPRO are working w MOH 🇻🇳. The variant detected is B.1.617.2 with an additional mutation(s), but more info soon.
Remember: variants are constellations of mutations. Many VOI/VOC have similar mutations