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20 Jul, 5 tweets, 1 min read
1/5 Polls!

While I am sure there will be some trolling (there always is 😂) I do want to check in on some general opinions regarding my work.

Let’s get started…
2/5 Which of the following two statements about me is more accurate?

1) I am obsessed with looking at lipid values in isolation (such as LDL by itself, leaving out HDL, triglycerides (TG), etc)

2) I am obsessed with looking at lipid in combination (such as LDL+HDL+TG together)
3/5 True or false –

I regularly give my opinion on LDL without any discussion on HDL and/or triglycerides.
4/5 True or false –

I regularly emphasize that I do not give medical advice.
5/5 Regarding risk context of high LDL when one has both high HDL and low TG (the “Lipid Triad”) from fat-adaptation— I regularly say which of the following:

1) I’m cautiously optimistic, but we need further research

2) I’m completely certain it is low risk

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More from @DaveKeto

Dave Feldman Profile picture
21 Jul
1/ I have a new favorite term: "unadjusted hypothesis-naïve exploratory linear regression"-- and it comes from @Ad_SotoMota, who @nicknorwitz and I are honored to be working with in this new project (news on that soon...)

I don't typically see the term as it's rarely employed...
2/ My layperson explanation is that this is explicitly letting the data speak for itself. Literally starting from scratch and seeing what patterns machine learning tells us are emerging. No adjusting the data at the beginning of the process which can bias the outcome (of course)
3/ I'm much more used to methodology sections describing several steps of adjustment selection by the researchers. This isn't to imply any wrongdoing by any means, but understandably, this can be problematic if one or more underlying assumptions for adjustments are incorrect...
Read 5 tweets
Dave Feldman Profile picture
13 Jul
1/ Very cool experiment and thread by @ScepticalDoctor who did a more #PlantBasedKeto and saw low #LDL #Cholesterol given high MUFA/PUFA relative to sat fat, along with high fiber (which supports my prior thread)

If looking to keep LDL low, this might be worth considering...
2/ As per my various tweets before this one on the topic, and not to beat a dead horse, I feel it is too often "low carb vs plant based" is often assumed the latter *must* be high carb -- thus, "low carb, animal-based vs high carb, plant-based"

... This is a false dichotomy...
3/ There are definitely some of us who are, as I like to say, "cautiously optimistic" with regard to higher LDL as appears to be resulting from metabolic fat adaptation in the context of higher sat fat, lower MUFA/PUFA and low to no fiber. But this risk degree is uncertain...
Read 6 tweets
Dave Feldman Profile picture
12 Jul
1/ #RespectfulDebate #Thread

From @ZDoggMD on his recent live video:

"... But the question then is – how do you actually solve this problem of having discourse and debate that's not in good faith. So we almost need like a third estate..."
2/ "... Like a different place where there's a very smart arbiter who's helping mediate. And it's all done in good faith, and the ideas actually get hashed out more. And the public can watch, right?

But such a thing doesn't really exist right now.

It really doesn't..."
3/ "... Because everybody is so tribalized, and it's very hard to get views on a YouTube or a Facebook doing that.

It's much easier to go 'full tribal'. Much much easier."

Of course, I couldn't agree more.
Read 8 tweets
Dave Feldman Profile picture
7 Jul
1/ Posting here for posterity. In my 2018 LMHR presentation I give a long section near the end where I encourage LMHRs to avoid "echo-chambering", check into different pro-LDL lowering voices (and mention Attia and Dayspring specifically), and extend my personal...
2/ ... promise to with regard to risk discovery and bringing it to attention within the community (and hey, now we're doing the LMHR study -- direct data coming soon).

I follow with a "that said," and posit that I suspect LMHRs will ultimately show low CVD and ACM...
3/ Because YouTube allows for jump-to-current-time links, someone straight up cut to the "that said" portion in order to exclude all the prior emphasis and efforts toward balancing.
Read 5 tweets
Dave Feldman Profile picture
6 Jul
1/ Great thread by @nicknorwitz

Yes, we started talking about this paper as I stumbled in it while looking up citations for a project we’re doing (more on that later)

Per my recent talks/threads, I think successful LPL activity (emphasis on “successful”) is key with triad/LMHRs
2/ But I had no idea there could actually be such a direct pathway to Acetate/Acetoacetate (AcAc) and LPL expression- being crucial for accessing fat stores. While this paper is a mouse model, it’s results are quite impressive when looking to knockout of GRP43 (GRP4-/-) vs normal
3/ and while Nick’s thread importantly mentions the fact these knockout mice *gained* weight on the ketogenic diet — I think a likewise incredible finding is that they also demonstrated far more difficulty in losing weight when eating nothing at all (fasting)
Read 5 tweets
Dave Feldman Profile picture
6 Jul
1/ #ListeningThread

Two fantastic intellectuals, @robbwolf and @lipoprotein, chatting about lipids, cardiovascular disease, and #LMHRs

Good podcast for my evening walk — might add some thoughts here…
2/ Wow, in the intro Rob mentions Bill having discussed LMHRs with me (and yes, we’ve had many great chats on the topic). Where he agrees, and where he disagrees. To be sure, I have a bit of an advanced preview on what that will likely be. ;) but I’m excited to hear it in the ep.
3/ 28:30 Bill: I think Dave Feldman has probably helped more than any one person in giving disability and how radically our bodies can change [lipid levels] in just days… So yeah, you can actually influence these results quite a bit in a 3 to 5 day period of time…
Read 28 tweets

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