Seems that the level4 restrictions in South Africa helped to control the third wave of #COVID19 - Reproductive number < 1 in the whole country and in most provinces.
The Western Cape and Eastern Cape seem to have peaked now, R =1
Gauteng #COVID19 cases are really in the downward path, R = 0.6
KwaZulu-Natal is current the dark horse, we do not know which will go as the recent decrease of R is associated with lack of testing due to disturbance. Recent cases are similar to before the disruption.
Northern Cape, North West, Free State, Mapumalanga and Limpopo seems to also have peaked in the third wave and these provinces have R less or equal to 1.

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More from @Tuliodna

30 Jun
NGS-SA worked hard to increase sequencing in South Africa. We know now that the explosive #COVID19 third wave is dominatedd by the Delta variant.

In this tweet thread, we present recent data (sampled up to 24 June in many provinces in SA, including Gauteng) - Tweet 1/8
This graph shows the distribution of the variants over time in the different provinces. 2/8
The third wave in Gauteng was caused by the Delta variant, thanks to @nicd_sa and @krisp_news who worked day and night on the weekend to increase genomics surveillance in Gauteng.
Graph shows Black line = Daily cases (7-day average), Yellow = Beta, Green = Delta. Tweet 3/8
Read 8 tweets
17 Jun
A Novel and Expanding SARS-CoV-2 Variant, B.1.1.318, dominates infections in Mauritius…
Mauritius is an example of controlling #COVID19 in Africa, with 1,700 infections and only 18 deaths. However, one variant seems to have caused the great majority of all of the infections
Mauritius has stopped dozens of introductions of the Beta (501Y.V2/B.1.351) and Alpha (B.1.1.7) but the B.1.1.318, which has the 484K mutation (common to Beta) and the 681H mutation (common to Alpha) has caused all local transmitted cases.
Read 14 tweets
3 Jun
In this online pre-print, we present a case of persistent SARS-CoV-2 infection with accelerated intra-host evolution in a patient with advanced HIV and antiretroviral treatment failure in South Africa.

Paper deposited at medRxiv &available at:… @sigallab
SARS-CoV-2 RT-PCR was positive for 216 days (27 weeks). At all time-points between day 0 and day 216 there was a mean Ct ranging from 16.4 to 31.6. The patient had HIV drug resistance and was not responding to therapy.
Over 30 mutations accumulated over time, many of them changing aminoacids that are common of variants of concern.
Read 15 tweets
14 May
A year of genomic surveillance reveals how the SARS-CoV-2 pandemic unfolded in Africa…
By 5 May 2021, 14,504 SARS-CoV-2 genomes had been submitted to the GISAID database from 38 African countries and two overseas territories (Mayotte and Réunion) (Fig. 1A). Overall, this corresponds to approximately one sequence per ~300 reported cases.
Overall, the number of sequences correlates closely with the number of reported cases per country. lmost half of the sequences were from South Africa, consistent with it being responsible for almost half of the reported cases in Africa.
Read 21 tweets
13 May
Confirmed Detection of eight (8) more genomes B.1.617.2 and two (2) community transmission of B.1.1.7 in South Africa, By Network for Genomic Surveillance in South Africa (NGS-SA), 13 May 2021
The eight new cases of B.1.617.2 variant have been detected from KwaZulu-Natal province. More specifically, these were cases in crew members of a commercial vessel that arrived in Durban Port from India.
The cases were isolated on the vessel, and other crew members have been quarantined according to national COVID-19 case management guidelines. The individuals who tested positive for COVID-19 did not disembark in South Africa, with exception of one that was admitted to hospital
Read 9 tweets
9 May
Confirmed Detection of B.1.617.2 and B.1.1.7 in South Africa by NGS-SA

This report was sent to our Health Minister @DrZweliMkhize yesterday.

In this Twitter thread, we highlight the details and repercussion of the discovery to South Africa
In response to the continued emergence and spread of new variants around the world, the Network for Genomic Surveillance in South Africa (NGS-SA) recently intensified the monitoring of confirmed COVID-19 cases in recent arrivals to the country.
We can now confirm that today we detected four cases of the B.1.617.2 variant. The four cases have been detected from Gauteng (n=2) and KwaZulu-Natal (n=2) provinces and all have a history of recent arrivals from India.
Read 17 tweets

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