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Daniel Witvliet Profile picture
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4 Aug, 3 tweets, 3 min read
How do brains rewire throughout life?

Our paper out in @Nature today outlines several principles of brain circuit development that we found by mapping the complete wiring of eight brains.

nature.com/articles/s4158…

#neuroscience #connectomics #brain #neurons #celegans #science
See highlights here:
PDF available here for anyone interested in the full story: rdcu.be/cr1BK

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Daniel Witvliet Profile picture
30 Apr 20
How does brain wiring change after birth? We tried to answer that question by mapping the wiring diagrams, or connectomes, of eight C. elegans brains across different life stages.

See our preprint (and this thread) for the insights we found: biorxiv.org/content/10.110…

1/9 Image
The size of neurites in the brain as well as the number of synapses increase significantly from birth to adulthood. Neurite growth is mostly uniform, maintaining the three-dimensional structure of the brain.

But synapse formation is not uniform throughout the brain..

2/9 Image
New synapses are more likely to (1) form new connections at large physical contacts, (2) converge onto highly-connected cells, and (3) maintain the relative strengths of a neuron's outputs.

Moreover, different connections show different synapse changes across maturation..

3/9
Read 9 tweets

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