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4 Aug, 7 tweets, 2 min read

1/ We have all heard of monoclonal gammopathy of renal significance, but which conditions are considered as a manifestation of MGRS?

2/ A recent KI Reports paper gives a nice review of MGRS
kireports.org/article/S2468-…

3/ 3% of the general population >50 years old has MGUS and only a small percentage (1%) progress to malignancy such as myeloma or lymphoplasmacytic lymphoma. These patients are observed over time and no chemotherapy is given

4/ In 2012, the International Kidney and Monoclonal Gammopathy Research Group formally defined patients with MGUS who had kidney damage due to the underlying monoclonal protein

5/ In patients with MGRS, the end-organ effect of monoclonal proteins takes priority over the hematological status of the patient

6/ Lesions on kidney biopsy due to MGRS include amyloidosis, light chain proximal tubulopathy, PGNMID, heavy chain deposition disease. Even immunotactoid or fibrillary glomerulonephritis demonstrating monoclonal Ig deposits are considered a part of MGRS.

@ghobby

7/ This article gives an in-depth review of MRGS and it’s diagnosis and is a nice read. Tweetorial brought to you by @ghobby

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More from @KIReports

KIReports

@KIReports

5 Aug

1/ A story about anti-GBM disease for #ThrowbackThursday — starting with the initial case report by Dr. Ernest Goodpasture himself. pubmed.ncbi.nlm.nih.gov/19680020/

2/ In late September 1918, Dr. Ernest Goodpasture admitted a patient to the hospital with what initially appeared to be a quote “typical attack of influenza.” He presented with a 3 day history of cough, dyspnea and fever to 103.0.

3/ He had no clinical evidence of pneumonia. His fever resolved and he was discharged home 3 days later. He felt ill after discharge, but returned to work. His cough persisted though, and weight loss and fatigue worsened.

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