[Thread] 1. Glenda Gray, co-lead investigator, #Sisonke:

We now have results to show the #JnJ jab provides significant protection @ the #DeltaVariant in SA.

What is Sisonke?

The Sisonke study used the #JnJ jab to look @ the effectiveness of the jab among SA #HealthWorkers
2. Gray:
1. #Sisonke vaccinated 477 234 #HealthWorkers
2. 122 sites were used to vaccinate health workers
3. Gray:
#Sisonke researchers used three sets of data to analyse the study's results:
1. 2 sets of data from medical insurers were used and one set of provincial persal data
2. Today Gray is only reporting on two sets of data
4. Gray:
1. #Sisonke ran from 17 February to 17 July (to collect data)
2. Researchers will continue to monitor trial participants for another two years to assess the durability of the protection that the #JnJ vaccine provides
5. Gray:
#Sisonke data shows the #JnJ vaccine provided 91-96.2% protection against death among #HealthWorker trial participants SA
6. Gray:
1. #Sisonke data shows the #JnJ vaccine provides protection against both the #BetaVariant and #DeltaVariant
2. The JnJ jab provides better protection against Delta than Beta, in other words vaccine efficacy for Delta is higher than for Beta
7. Gray: What kind of protection did the #JnJ provide against hospitalisation and death in #Sisonke?
1. The JnJ jab provided 65-66% protection @ hospitalisation
2. The JnJ jab provided 91-95% protection @ death
8. Gray: What about protection @ specifically Delta and Beta?
1. The #JnJ jab provided 67% protection @ hospitalisation as a result of infection with the #Beta variant
2. JnJ vaccine provided 71% of protection @ hospitalisation as a result of infection by the #DeltaVariant
9. Gray: Is the #JnJ jab safe?
1. #Sisonke data showed that the #JnJ vaccine is safe to use
2. Two rare blood clot events occurred among trial participants, but both cases have fully recovered
3. Sisonke will continue to monitor participants for 2 more years to assess safety
10. Gray:
1. #Sisonke data shows there is good durability for the protection that the #JnJ jab provides:
- Protection @ hospitalisation (65%) was the same 28 days after vaccination and 120 days after vaccination
2. Sisonke data shows, at this stage, no booster shot is required
11. Gray:
1. #Sisonke provided the world's first data that the #JnJ vaccine is effective against the #DeltaVariant
2. Real world effectiveness studies show similar vaccine efficacy of the JnJ vaccine.

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More from @miamalan

5 Aug
LATEST #VaccineRollOutSA stats: Thu, 5 Aug:

[Thread] 1. We've fully vaccinated 8.6% of adults in SA

1. Jabs, past 24 hrs: 181, 096 (Wed: 185, 949)
2. Total doses: 8, 377, 606
3. Adults fully vaccinated: 3, 447, 380 (8.6%)
2. How many adults were fully vaccinated in the last 24 hours? 111, 205 (most of these vaccinations happened in Gauteng, KZN and Limpopo)
- #JnJ: 60, 464
- #Pfizer: 50, 741
3. Cool new @healthza dashboard feature: Breakdown of vaccinations by age and gender:
1. % of men: 39.77%
2. % of women: 60.23%

Vaccine doses administered per age group:
60+: 4, 469, 450
50-59: 1, 658, 651
35 - 49: 1, 851, 896
18-34: 392, 869
Read 4 tweets
2 Aug
[Thread] 1. When will our new vaccine stock reach #VaccineRollOutSA sites?

@healthza says:
#JnJ (1, 454, 900 doses released by Aspen last wk): Tu onwards
#Pfizer (1,5 mil doses we bought; arrived on Sun): Thu onwards
Pfizer (2.8 mil US donated doses; arrived on Sat): Next week
2. When will our new #Pfizer doses expire?

@healthza says:

Both the 2.8 mil donated #Pfizer doses and the 1.5 million procured doses expire on 30 November 2021
3. When will our new #JnJ doses expire? 31 May 2023

When will our current JnJ doses expire?
11 Aug

How many of the old JnJ doses have we got left?
@healthza's dashboard says we had used 1, 053, 862 by 1 Aug
1, 500, 000 - 1, 053, 862 = 446 138
Read 4 tweets
30 Jul
[Thread] 1. What's happening with our #VaccineRollOutSA doses — will we have enough and are we reaching the right people?

Nicholas Crisp, @healthza:
We crossed the 7 mil mark for vaccine doses administered this week, but we're not yet reaching enough 60+ (most vulnerable).
2. Crisp:
1. 80% (4, 416, 391) of 60+ have been vaccinated with at least one dose
2. 15% (727, 839) of 50+ have been vaccinated with at least one dose

@healthza's goal for Aug: 1 out of 7 vaccinations has to be for 60+
3. Crisp:
We're not reaching the desired public/private mix for jabs: there is far more capacity in the private sector than what we're currently using

Below is a screen grab from @healthza's dashboard that shows a breakdown of the % of jabs done at pub/priv sites on Thu
Read 8 tweets
30 Jul
[Thread] 1. How far are we behind with our original #VaccineRolloutSA targets? Dr Jabu Mtsweni from @CSIR has analysed this.

What is our target? To vaccinate 40 million adults in SA by March 2022.
2. How do we measure if we're reaching targets?
1. We can look at the nr of doses we administer in either a 5 (without weekends) or 7 day week
2. We can count how many people are fully vaccinated, but the nr of doses we count are different for JnJ (1 dose) and Pfizer (2 doses)
3. So how is SA doing?
1. Average nr of doses/day = 173 258
2. 80% of the doses = Pfizer (2 doses) and 20% = JnJ (Pfizer was up until recently, the only jab available to SA to roll out at sites)
3. Using more 2 dose jabs makes us move slower on targets for full vaccinations
Read 12 tweets
28 Jul
[Thread] 1. Are the 5.6 mil #Pfizer doses the US gov is donating to SA in addition to the Pfizer doses we've already procured ? YES (confirmed by @healthza)
2. How many #Pfizer doses has SA received up until now (so doses we've bought/paid for)?
@healtza figures:

Pfizer (bilateral deal): 6, 606, 990
Pfizer via #COVAX: 1, 392, 300

TOTAL: 7, 999, 290
3. How many #JnJ doses has SA received so far (without #Sisonke's JnJ research doses)?

@healthza figures:
1, 553, 600
(1, 49 million doses will be at clinics next week — these are the doses released by Aspen to #JnJ on Monday)
Read 4 tweets
27 Jul
[Thread] 1. What % of SA adults have now been fully vaccinated + with which jab?

Fully vaccinated adults (people of 18+) = 6.1%
- 3.1% have been fully vaccinated with #JnJ (they had 1 shot)
- 3% have been fully vaccinated with #Pfizer (they had 2 shots)

(3.1% + 3% = 6.1%)
2. How are provinces doing with full vaccinations?
Limpopo (8.5%), KZN (7.5%) and the Eastern Cape (7.2%) are leading the way, proportion-wise.

But when it comes to numbers, Gauteng (549 421) and KZN (543 580) have the highest number of fully vaccinated adults.
3. How do you work out how many people have been fully vaccinated? @healthza has a dashboard: bit.ly/3y9JEJV

Total full vaccinations =
#JnJ shots (1, 242, 236, you need 1 shot) + #Pfizer 2nd shots (1, 194, 931, you need 2 shots) = 2, 437 167
Read 8 tweets

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