Weekend Digest
Name the pathogen and its treatment
(Photo CDC)
Name the pathogen and its treatment
(Photo CDC)
2/
#Plasmodium #falciparum
1. Anopheles bite
2. Endemic regions / returning travelers: 12-14 day incubation period
3. Fever +/- severe symptoms (see next)
4. Dx: blood smear, rapid diagnostic Ag or Ab test
5. Rx: chloroquine, artemisin-based combination Rx (depends on region)
#Plasmodium #falciparum
1. Anopheles bite
2. Endemic regions / returning travelers: 12-14 day incubation period
3. Fever +/- severe symptoms (see next)
4. Dx: blood smear, rapid diagnostic Ag or Ab test
5. Rx: chloroquine, artemisin-based combination Rx (depends on region)
3/
#Plasmodium #falciparum is severe if with end-organ S/S
AMS / seizures
Acidosis
Hypoglycemia
Severe anemia
Renal failure
Jaundice
Pulmonary edema
Bleeding
Shock
High level parasitemia
#Plasmodium #falciparum is severe if with end-organ S/S
AMS / seizures
Acidosis
Hypoglycemia
Severe anemia
Renal failure
Jaundice
Pulmonary edema
Bleeding
Shock
High level parasitemia
4/
#Plasmodium #falciparum Rx
Uncomplicated:
1. Chloroquine, if susceptible
2. If chloroquine-R: artemisin-based combination Rx (e.g., artemether-lumefantrine)
Severe: parenteral route initially
1. Artemisin (artesunate, artemether)
2. Cinchona alkaloids (quinine) as alternate
#Plasmodium #falciparum Rx
Uncomplicated:
1. Chloroquine, if susceptible
2. If chloroquine-R: artemisin-based combination Rx (e.g., artemether-lumefantrine)
Severe: parenteral route initially
1. Artemisin (artesunate, artemether)
2. Cinchona alkaloids (quinine) as alternate
/5
#Plasmodium #falciparum
Artesunate substantially reduces mortality in severe malaria.
This study strongly suggest that parenteral artesunate should replace quinine as Rx of choice for severe falciparum malaria.
doi.org/10.1016/S0140-…
#Plasmodium #falciparum
Artesunate substantially reduces mortality in severe malaria.
This study strongly suggest that parenteral artesunate should replace quinine as Rx of choice for severe falciparum malaria.
doi.org/10.1016/S0140-…
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