Mice were given a ketosis inducing high fat diet (using MCT oil as 80% of calories), this reduced tumour mass whilst maintaining body weight, reducing cachexia, which is the most dangerous phase of cancer.
The problem in dietary interventions in mice studies, is a lack of clarity in an accurate description of the diet and its subsequent metabolic/endocrine effects. Many research papers, when calling an intervention a high fat diet, they actually mean high carb with high fat...
Usually the calories from fat and carbs are roughly equal and the remainder is protein. This is literally the western diet! the worst combination.
A high fat diet that is ketogenic, is v low in carbohydrates. The degree of carbohydrate restriction varies between species. Degree of restriction may be modulated depending on primary source of fat, with MCT oil being very ketogenic, allowing for a greater carbohydrate % intake
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Patients with T2DM, CVD, conditions of hyperinsulinaemia, have lower: bone remodelling and osteocalcin levels, and increased rates of fragility fractures.
T2DM “hyperinsulinaemia-osteofragilitas” bone phenotype presents with normal to increased BMD mdpi.com/2227-9059/9/9/…
Hyperinsulinaemia and IR positively associate with increased BMD and fragility fractures
Trends in Prevalence of Diabetes Among US Adults, 1999-2018
Cross-sectional study
n=28,143 participants from NHANES
Estimated age-standardized prevalence of diabetes increased significantly, from 9.8% in 1999-2000 to 14.3% in 2017-2018 jamanetwork.com/journals/jama/…
This is data where diabetes is overt. There are stages of T2 diabetes:
stage 1: hyperinsulinemia with normal glucose levels,
stage 2: hyperinsulinaemia with mildly elevated glucose levels (aka pre-diabetes),
stage 3: hyperinsulinemia with hyperglycaemia (full blown T2DM),…
…stage 4: hyperinsulinaemia with hyperglycaemia and progression into pseudo-type 1 beta cell failure.
Hyperinsulinaemia may precede hyperglycaemia by up to 24 years. Meaning, if we wait till a person is at stage 2 Type2DM (aka pre-diabetes), it is already very late.
Why spike protein containing or mRNA transcription to self-produce the spike protein (S-protein) is likely to increase blood clotting and inflammation, especially in at-risk individuals:
The SARS-CoV2 (SARS2) spike protein is biologically active.
The injected S protein (or program via mRNA to induce self-production of the S protein) alone damages vascular endothelial cells (ECs) in vitro and in vivo, manifested by impaired mitochondrial function, decreased ACE2 expression and eNOS activity, and increased glycolysis.
Increased glycolysis indicates impairment of the mitochondria. Upregulation of this pathway activates inflammatory signalling cascades. The decrease in eNOS activity further increases vasoconstriction.
What we have heard loudest from Government, mainstream media and med/scientists with vested interests, is we must: “socially distance, lockdown to slow/lower spread rate, protect the health care systems, wait for vaccines before life has any hope of returning back to normal”.
The health system factor, in contributing to COVID-19 mortality rate in the first quarter of 2020. However, the positive is also to be seen in this study (Anesi et al., 2021) in the application of a system that enabled rapid…
..frequent real-time iterative updates in sharing of knowledge btn health carers to recognise ineffective and/or dangerous interventions and where health carers see positive effective measures, in-order to adjust standard operating procedures (SOPs) to improve patient outcomes...
As a result, mortality rate decreased over time despite stable patient characteristics.