cancerres.aacrjournals.org/content/49/14/…

Can you believe, this was published in 1989.

Mice were given a ketosis inducing high fat diet (using MCT oil as 80% of calories), this reduced tumour mass whilst maintaining body weight, reducing cachexia, which is the most dangerous phase of cancer.
The problem in dietary interventions in mice studies, is a lack of clarity in an accurate description of the diet and its subsequent metabolic/endocrine effects. Many research papers, when calling an intervention a high fat diet, they actually mean high carb with high fat...
Usually the calories from fat and carbs are roughly equal and the remainder is protein. This is literally the western diet! the worst combination.
A high fat diet that is ketogenic, is v low in carbohydrates. The degree of carbohydrate restriction varies between species. Degree of restriction may be modulated depending on primary source of fat, with MCT oil being very ketogenic, allowing for a greater carbohydrate % intake

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More from @I_mitochondria

6 Sep
Patients with T2DM, CVD, conditions of hyperinsulinaemia, have lower: bone remodelling and osteocalcin levels, and increased rates of fragility fractures.

T2DM “hyperinsulinaemia-osteofragilitas” bone phenotype presents with normal to increased BMD mdpi.com/2227-9059/9/9/…
Hyperinsulinaemia and IR positively associate with increased BMD and fragility fractures

Hyperinsulinaemia enforces glucose fuelling, decreasing NAD+-dependent antioxidant activity:

➡️⬆️ ROS & mt fission,
➡️⬇️ OxPhos ATP production capacity, needed for osteoblasto/cytogenesis.
Osteocytes directly mineralise and resorb bone, & inhibit mineralisation of their lacunocanalicular space via pyrophosphate.

Hyperinsulinaemia decreases vitamin D availability via adipocyte sequestration, reducing dendrite connectivity, and compromising osteocyte viability.
Read 7 tweets
26 Jun
Trends in Prevalence of Diabetes Among US Adults, 1999-2018

Cross-sectional study
n=28,143 participants from NHANES

Estimated age-standardized prevalence of diabetes increased significantly, from 9.8% in 1999-2000 to 14.3% in 2017-2018 jamanetwork.com/journals/jama/…
This is data where diabetes is overt. There are stages of T2 diabetes:

stage 1: hyperinsulinemia with normal glucose levels,

stage 2: hyperinsulinaemia with mildly elevated glucose levels (aka pre-diabetes),

stage 3: hyperinsulinemia with hyperglycaemia (full blown T2DM),…
…stage 4: hyperinsulinaemia with hyperglycaemia and progression into pseudo-type 1 beta cell failure.

Hyperinsulinaemia may precede hyperglycaemia by up to 24 years. Meaning, if we wait till a person is at stage 2 Type2DM (aka pre-diabetes), it is already very late.
Read 8 tweets
12 Jun
Risk of exposure to babies being fed by mothers vaccinated with SARS-CoV-2 experimental vaccine-mRNA

There can be no assurances of safety, with so many unknowns

hartgroup.org/risk-to-babies…
It is being claimed that:

1.Human breast milk does not contain SARS-CoV-2 vaccine-mRNA; and

2.That if there were any vaccine-mRNA in breast milk, it would not survive the nursing infant’s digestive tract.

facebook.com/10001433352474…
Current claims regarding the safety of the vaccine-mRNA itself are not supported by robust evidence.

In a recent preprint, Low et al. (2021) detected SARS-CoV-2-COVID19 (SARS2) vaccine-mRNA in human breast milk.

medrxiv.org/content/10.110…
Read 39 tweets
2 May
Why spike protein containing or mRNA transcription to self-produce the spike protein (S-protein) is likely to increase blood clotting and inflammation, especially in at-risk individuals:
The SARS-CoV2 (SARS2) spike protein is biologically active.

ahajournals.org/doi/full/10.11…
The injected S protein (or program via mRNA to induce self-production of the S protein) alone damages vascular endothelial cells (ECs) in vitro and in vivo, manifested by impaired mitochondrial function, decreased ACE2 expression and eNOS activity, and increased glycolysis.
Increased glycolysis indicates impairment of the mitochondria. Upregulation of this pathway activates inflammatory signalling cascades. The decrease in eNOS activity further increases vasoconstriction.

ahajournals.org/doi/full/10.11…
Read 26 tweets
31 Jan
The world’s most powerful tools against respiratory infections is good health, individual health and population health. Both metabolic and mental.

dx.doi.org/10.1136/openhr…

#hyperinsulinaemia
#covid
#vitD
#metabolichealth
#immunity openheart.bmj.com/content/7/2/e0…
“heightened fears that the coronavirus is quickly finding ways to elude the world’s most powerful tools (vaccines) to contain it.”

latimes.com/science/story/…
What we have heard loudest from Government, mainstream media and med/scientists with vested interests, is we must: “socially distance, lockdown to slow/lower spread rate, protect the health care systems, wait for vaccines before life has any hope of returning back to normal”.
Read 22 tweets
30 Jan
An uncomfortable topic:

The health system factor, in contributing to COVID-19 mortality rate in the first quarter of 2020. However, the positive is also to be seen in this study (Anesi et al., 2021) in the application of a system that enabled rapid…

doi.org/10.7326/M20-53…
..frequent real-time iterative updates in sharing of knowledge btn health carers to recognise ineffective and/or dangerous interventions and where health carers see positive effective measures, in-order to adjust standard operating procedures (SOPs) to improve patient outcomes...
As a result, mortality rate decreased over time despite stable patient characteristics.
Read 14 tweets

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