Thread by @theABofPharmaC

Now that the salty🧂debate on the TYPE of fluid to use in the ICU has largely been solved, how about the RATE of IVF? 🤔

Back to the BaSICS💦

✅The Balanced Solutions in Intensive Care Study📖 (BaSICS) ▶️compared 333mL/hr vs 999 mL/h

Does IVF rate impact 90-day mortality? 🤔

💡 10, 520 ICU pts randomized 🏥

Fluid volume:

1162 mL in the SLOW infusion group 💦
vs. 1252 mL in the FASTer group

🛑NO difference in☝️ outcome: 90-day mortality (HR 1.03, CI, 0.96-1.11)

🛑No difference in✌️outcomes: RRT, AKI, ventilator free days, ICU/hospital LOS

Notably, when reviewing this study, the baseline characteristics are a key 🔑 consideration

< 5% of the cohort in both groups had sepsis (⬇️ the generalizability in this population) 🦠

Patients with AKI or ESRD were excluded from the trial 💡

While 90-day mortality is a complex outcome to define appropriateness of an acute, 1x intervention, this study is important 💡

✅No clear guidelines exist to guide rate of IVF bolus
✅May help ⬇️ concerns regarding safety of fast 💨 infusions

#PharmICU #critcare

Here’s a link to the full trial 🔬 as well as a summary using the visual abstract! @JAMA_current

jamanetwork.com/journals/jama/…

Feel free to share if this study is practice changing!