💡AMAZING BOOSTER DATA—New study shows 3rd shot has 91% efficacy (11x ⬇️lower risk) against #DeltaVariant infection versus 2 shots (>=5 months earlier) among age 60+. Plus, 3rd shot has ~95% efficacy (19.5x ⬇️lower risk) against severe disease!🧵 #COVID19nejm.org/doi/full/10.10…
2) moreover. The enhanced booster effects begin being apparent after day 12, increasing higher effects starting even day 10 after the shot perhaps.
3) most were not that elderly either 60-69. I’m also glad to see they enrolled 14% Arab population. The bulk were vaccinated in early February. Thinking of all the people who got vaccines before March that could benefit from this.
4) forgot to mention, Israel study used Pfizer- BioNTech vaccine. Also when analysis restricted to the general Jewish population, the rate ratio was 10.8 for infection & 21.7 lower for severe illness—thus, meaning result similar regardless of mainstream Jewish, Orthodox or Arab.
5) I’m also eager for data on Moderna booster shots, given that 2 doses of Moderna have higher efficacy than 2 doses of Pfizer and much higher than 1 dose of J&J—this is from a major CDC study. I think we need boosters - 3rd shot for elderly, and 2nd shot for J&J ASAP!
BREAKING—experts unanimously recommended #COVID19 booster be authorized for people 65 and older and those at high risk of severe disease—GOOD. However, voted against boosters for age 16-64 for 6+ months since 2nd shot—POOR DECISION. We see waning already. washingtonpost.com/health/2021/09…
2) The discussion highlighted the tensions that are likely to erupt once committee members discuss the data Friday afternoon.
“We know that there may be differing opinions about the interpretation of the data regarding the potential need for additional doses…”
3) “and we strongly encourage all the different viewpoints to be voiced and discussed, regarding the data which is complex and evolving,” said Peter Marks, the FDA official overseeing coronavirus vaccines.”
📍BOOSTER—3rd dose data presented to @US_FDA panel - shows 17x fold & +2000 increase in neutralization with a 3rd dose booster, after waning seen after 2 doses. I wouldn’t want to stay at the 136 neutralization—I’d prefer protection at ~2300 neutralization level. #BoosterShots
2) Plus it seems the side effects after 3rd Pfizer shot dose is much less frequent and milder than after 2nd shot! This is great news.
3) This is why we see huge improvement in efficacy against #deltavariant with a 3rd dose. See 🧵 below
$5.7 billion could solve a lot of problems in this world… if only unvaccinated people didn’t burn all that money up in smoke, orphan countless kids, harm their future, and devastate the economy further by prolonging #COVID19. Please #vaccinate. 🧵
2) In August, the new analysis estimates that the preventable costs of treating unvaccinated patients in hospitals total $3.7 billion, almost twice than June & July combined. The total preventable costs for 3 months now an estimated $5.7 billion. google.com/amp/s/www.kff.…
3) “The estimates draw on KFF’s analysis of U.S. Department of Health and Human Services data about COVID-19 hospital admissions… **each COVID hospitalization on average results in roughly $20,000** in hospital costs.” 👀
2) BUT—“It’s hard to assess the current toll of the virus on people living and working inside long-term care facilities, as Florida stopped sharing this data with the public in May.” ⚠️
3) “Federal data used in the AARP report lags by about two weeks, and does not include information about the situation inside Florida’s assisted living facilities, which are not required to report to the national government.”
📍NOT ENOUGH TO STOP VARIANTS—U.S. population immunity against #COVID19 still insufficient to resume pre-pandemic social behavior—still not enough #vaccination / natural immunity—need more masks & ventilation on top to prevent additional waves of variants. acpjournals.org/doi/10.7326/M2…
2) “The mean overall population immunity was 62.0% (CrI, 58.4% to 66.4%). Adults aged 65 years or older were estimated to have the highest immunity level (77.2% [CrI, 76.2% to 78.6%])…”
3) HOWEVER- “children younger than 12 years had the lowest immunity level (17.9% [CrI, 14.4% to 21.9%])” acpjournals.org/doi/10.7326/M2…