📍BREAKING—At last—new data on 2-doses of Johnson & Johnson's #vaccine (doses 56 days apart) is 94% effective against symptomatic #COVID19, thus comparable to Moderna/Pfizer. And 100% effective against severe COVID. Booster for 1 dose works well too. 🧵
cnn.com/2021/09/21/hea…
cnn.com/2021/09/21/hea…
2) "Our large real-world-evidence and Phase 3 studies confirm that the single-shot Johnson & Johnson vaccine provides strong and long-lasting protection against COVID-19-related hospitalizations,"
3) "Our single-shot vaccine generates strong immune responses and long-lasting immune memory. And, when a booster of the Johnson & Johnson COVID-19 vaccine is given, the strength of protection against COVID-19 further increases."
4) second study showed people given a booster shot six months or longer after their first dose had a 12-fold increase in antibodies -- compared to a four-fold increase for people who got a second dose at two months.
5) So protection should be stronger if people get boosters later, Dr. Dan Barouch, head of Beth Israel Deaconess' Center for Virology and Vaccine Research, told CNN.
"If you wait longer and have boost at six months or later then you likely will have better boost” 👀
"If you wait longer and have boost at six months or later then you likely will have better boost” 👀
6) Third, the company said a real-world evidence study of 390,000 people in the US, using health insurance records through July -- so covering the Delta variant -- showed the one-shot J&J vaccine was 81% effective at preventing hospitalizations.
7) "The Johnson & Johnson single-shot COVID-19 vaccine showed vaccine effectiveness against COVID-19-related hospitalizations at 86% for participants younger than 60 years, and 78% for those 60 years and older," the company said.
8) "Among 390,517 vaccinated and 1,524,153 matched unvaccinated individuals, vaccine effectiveness 79% for COVID-19 and 81% for COVID-19-related hospitalizations," the Janssen-led research team wrote in a study posted online in a preprint. medrxiv.org/content/10.110…
9) "In these states, vaccine effectiveness for observed COVID-19 was 79% overall and 78% during June and July, the months where Delta variant incidence was highest," they added.
10) Let’s look at the data on J&J 2 doses (led by analytics epidemiology team from @aetioninc) - the efficacy is slightly higher in those age <60 and in those not immunocompromised. But overall, the efficacy held well, even in high #DeltaVariant states and months.
11) Johnson & Johnson has said it will submit all of this data to the FDA for potential consideration for adding a booster dose, and perhaps for consideration to authorize a two-dose regimen.
12) The Janssen vaccine is made using a different technology from Moderna's and Pfizer's vaccines. The mRNA vaccines deliver messenger RNA or mRNA directly to the body wrapped in compounds called lipids.
13) The J&J vaccine is made using an adenovirus, a common cold virus, that's been engineered so it can get into cells, but then stops. It delivers genetic instructions that way.
14) "For outstanding protection, then a second shot can be given at any time between two months and eight months -- and the longer you wait, the better."
That, he said, is because the body mounts a variety of immune responses.
That, he said, is because the body mounts a variety of immune responses.
15) Antibodies -- immune system proteins that can either flag an invader or directly attack and neutralize it -- build up quickly but can wane over time.
The body also produces cells called B cells and T cells, and these contribute to longer-term protection.
The body also produces cells called B cells and T cells, and these contribute to longer-term protection.
16) Stimulating B cells with a boost after time -- after they have become less active -- appears to cause them to generate fresh antibodies more effectively, he said.
17) As I noted a month ago, a J&J booster was inevitable and pending. Glad it’s coming soon.
https://twitter.com/DrEricDing/status/1428092413097254913
18) Folks— I’ve always said J&J was “underrated” as a vaccine. It was always a pretty decent vaccine considering it’s been a one dose out until now. Many also forgot how J&J efficacy grew other time. Now we see it clearly!
https://twitter.com/drericding/status/1366619383997607941
19) Remember we need 2 doses of a vaccine as a minimum for good reason based on immunology. And new J&J study says ➡️booster shot 6 months or longer after first dose had a **12-fold increase** in antibodies -- compared to 4-fold increase if second dose at two months. 👀
20) for those who say 1-shot 80% efficacy is enough… remainder that means that instead of 1000 cases in a community, there is still 200 (80% lower). It’s good but not as good as 60 (94% lower) and 0 deaths (100% efficacy) with 2 shots. Please get two shots.
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