When asked if people should get the flu shot this fall, Paul Marik says “truth be told in the last few years, the risk of being hospitalized after the vaccine was the same as placebo. In recent years the flu vaccine has been completely ineffective...” 1/2
Marik goes on “and indeed I’m not an anti-vaxxer. The risk of Guillian-Barre Syndrome exceeded the risk of being hospitalized … for influenza. So you know what? People need to decide for themselves.”
Yikes! Next these lunatics will be railing against tetanus vaccines.
2/2
For those wondering what Cochrane *actually* says on this subject:
In a population of healthy adults, influenza vaccination reduce influenza & influenza like illness. They may reduce hospitalizations.
For those over 65 yo or with comorbidities the benefits are likely larger.
And yes Marik’s GBS claim is also completely untrue.
Getting the flu is a much bigger risk for developing GBS than vaccination. (Unless you travel back to 1976 and get that years swine flu vaccine)
Time for part 4️⃣ of my comparative physiology series:
Case 1
You are called about an elevated blood alcohol level in an inpatient.
"That’s impossible," the tech says, "he’s been admitted to the ICU for a month!"
It’s totally normal, you say, because the sample came from a __
1/
Answer: 🐠
Under anoxic conditions vertebrates produce lactate. This accumulates causing acidosis.
Goldfish & carp are unique b/c they can convert lactate to ethanol, which diffuses out of their gills into the water. They can survive w/o O2 for months! nature.com/articles/s4159… 2/
Other answers
Bats & primates are good ethanol metabolizers by necessity due to a diet that includes fermented fruit.
The Pen Tailed Shrew is an especially fast ethanol metabolizer: adjusted for size, it consumes the equivalent of 9 beers/day! 3/
One bizarre argument I keep seeing is that “if ivermectin was ‘approved for COVID’ the vaccines would lose their EUA status because there would be an alternative treatment.”
This is untrue (and a particularly stupid argument) for several reasons.
A short thread. 1/
First of all there *ARE* FDA approved, NIH recommended therapies that reduce COVID mortality & are currently in widespread use:
- dexamethasone
- tocalizumab
- baricitinib
If the mere existence of an “alternative therapy” instantly voided an EUA it would have already happened 2/
Second, one of the vaccines (the Pfizer-BioNTech mRNA vaccine) *ALREADY HAS* full FDA approval.
The full approval of the Pfizer vaccine on 8/23 means that Pfizer doesn’t have an EUA anymore. It also didn’t magically invalidate the other 2 vaccine EUAs. 3/ fda.gov/news-events/pr…
The last few weeks have been tough. For those in need of a light hearted thread, here’s a brand new 3rd #tweetorial in my extremes of #physiology series. What can the animal kingdom teach us about our physiology?
Buckle up for some fun animal pulmonary facts 🫁!
1/
CASE 1:
You are performing a bronchoscopy. Upon reaching the main carina instead of the usual TWO airways (right & left mainstem bronchi) you see THREE.
Your assistant says “Whoa! That’s weird”
You say no it’s totally normal because the patient is a:
2/
Answer: 🐖
In pigs, the RUL lobe bronchus originates from the supra-carinal trachea (e.g. before the R & L mainstream branches). The view from the trachea looks like this (see the tracheal bronchus on the right).
The #COVBARRIER RCT now published @LancetRespirMed & it looks like we have a new COVID tx: Baricitinib
-n=1525 hospitalized COVID pts not on IMV
-lower mortality w/ Bari compared to placebo (10% vs 15%) (NNT = 20) & larger benefit in sicker pts!
-bit.ly/3yDmJ9r 1/
COV-BARRIER was a 101 site, double blind RCT performed in 11 countries.
It enrolled hospitalized COVID patients who were hypoxemic (but not on IMV) and had evidence of inflammation.
It had many exclusion criteria including monoclonals, immunesuppression. This is a🔑 point. 2/
The intervention was 4mg of baricitinib, an orally available JAK1/2 inhibitor, dosed once daily for 14 days or until hospital d/c. (It can be crushed and given by FT).
Bari is an FDA approved treatment for RA. It costs ~$50-75 per pill (thus a 14 day course is ~$700-1000). 3/
As the evidence supporting ivermectin as COVID treatment collapses, you might expect *less* certainty from the drug’s evangelists.
Instead they’ve doubled down on ivermectin.
It’s worth reading this passage from Festinger’s Theory of Cognitive Dissonance to understand: 1/
For context, Festinger & colleagues joined a cult (“The Seekers”) who believed the world would end on December 21, 1954 & that true believers would be rescued by a UFO
The researchers wondered how the Seekers would react to “disconfirmation” when this didn’t happen.
2/
As the date approached, the researchers watched many “Seekers” take irrevocable steps because of their belief: they quit their jobs, severed ties to loved ones, & disposed of possessions.
What would happen when their beliefs were discredited? 3/
First off, I’m sorry that you got COVID and I’m glad you recovered. I respect that you have the integrity to admit that ivermectin wasn’t able to prevent your illness. 1/
I’ve read the same studies & I disagree with your assessment of IVM; A few small methodologically flawed studies are just not compelling in light of negative results from large high quality RCTs. @cochranecollab & many experts have likewise concluded that IVM is ineffective
2/
What I find alarming is your failure to use your platform to advocate for vaccination. You claim to follow the evidence. Do you really think there is more evidence for daily mouthwash use than for vaccination to prevent COVID?