One bizarre argument I keep seeing is that “if ivermectin was ‘approved for COVID’ the vaccines would lose their EUA status because there would be an alternative treatment.”

This is untrue (and a particularly stupid argument) for several reasons.

A short thread.
1/ ImageImage
First of all there *ARE* FDA approved, NIH recommended therapies that reduce COVID mortality & are currently in widespread use:
- dexamethasone
- tocalizumab
- baricitinib

If the mere existence of an “alternative therapy” instantly voided an EUA it would have already happened
2/ ImageImage
Second, one of the vaccines (the Pfizer-BioNTech mRNA vaccine) *ALREADY HAS* full FDA approval.

The full approval of the Pfizer vaccine on 8/23 means that Pfizer doesn’t have an EUA anymore. It also didn’t magically invalidate the other 2 vaccine EUAs.
3/
fda.gov/news-events/pr…
Clearly “approval of a cheap, widely available and effective COVID therapy” (e.g. dexamethasone) didn’t “invalidate the vaccine’s EUA”

Even full approval of one vaccine didn’t invalidate the EUAs for the other 2; Moderna and J&J remain available

Don’t believe the nonsense!
4/
There is a tiny nugget of truth here: an emergency use authorization (EUA) *DOES* require 4 conditions to be met:
1. a public health emergency
2. proof of effectiveness
3. benefits > harm
4. no adequate, approved, & available alternative (at the time of EUA submission)
5/ Image
IVM zealots fixated on #4. But different types of treatments aren’t considered “alternatives”.

For example, widespread availability of steroids doesn’t preclude other immunomodulator therapies (toci, bari, etc)

Similarly monoclonal antibodies & vaccines are not alternatives
6/
At this point there have been over 600 EUAs granted for COVID related products (mostly diagnostic tests). Each has specific indications.

When a new therapy is approved it doesn’t invalidate all the prior ones.
7/
fortune.com/2021/06/07/cov…
Bottom line: if someone tells you “if ivermectin were accepted the vaccines would lose their EUA status” it’s a pretty clear signal that they don’t know what they are talking about.
8/8

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More from @nickmmark

4 Sep
The last few weeks have been tough. For those in need of a light hearted thread, here’s a brand new 3rd #tweetorial in my extremes of #physiology series. What can the animal kingdom teach us about our physiology?

Buckle up for some fun animal pulmonary facts 🫁!
1/
CASE 1:
You are performing a bronchoscopy. Upon reaching the main carina instead of the usual TWO airways (right & left mainstem bronchi) you see THREE.

Your assistant says “Whoa! That’s weird”

You say no it’s totally normal because the patient is a:
2/
Answer: 🐖
In pigs, the RUL lobe bronchus originates from the supra-carinal trachea (e.g. before the R & L mainstream branches). The view from the trachea looks like this (see the tracheal bronchus on the right).

image source: casereports.bmj.com/content/12/5/e…
3/
Read 26 tweets
1 Sep
The #COVBARRIER RCT now published @LancetRespirMed & it looks like we have a new COVID tx: Baricitinib
-n=1525 hospitalized COVID pts not on IMV
-lower mortality w/ Bari compared to placebo (10% vs 15%) (NNT = 20) & larger benefit in sicker pts!
-bit.ly/3yDmJ9r
1/
COV-BARRIER was a 101 site, double blind RCT performed in 11 countries.

It enrolled hospitalized COVID patients who were hypoxemic (but not on IMV) and had evidence of inflammation.

It had many exclusion criteria including monoclonals, immunesuppression. This is a🔑 point.
2/
The intervention was 4mg of baricitinib, an orally available JAK1/2 inhibitor, dosed once daily for 14 days or until hospital d/c. (It can be crushed and given by FT).

Bari is an FDA approved treatment for RA. It costs ~$50-75 per pill (thus a 14 day course is ~$700-1000).
3/
Read 12 tweets
25 Aug
As the evidence supporting ivermectin as COVID treatment collapses, you might expect *less* certainty from the drug’s evangelists.

Instead they’ve doubled down on ivermectin.

It’s worth reading this passage from Festinger’s Theory of Cognitive Dissonance to understand:
1/
For context, Festinger & colleagues joined a cult (“The Seekers”) who believed the world would end on December 21, 1954 & that true believers would be rescued by a UFO

The researchers wondered how the Seekers would react to “disconfirmation” when this didn’t happen.
2/
As the date approached, the researchers watched many “Seekers” take irrevocable steps because of their belief: they quit their jobs, severed ties to loved ones, & disposed of possessions.

What would happen when their beliefs were discredited?
3/
Read 16 tweets
20 Aug
.@PierreKory

First off, I’m sorry that you got COVID and I’m glad you recovered. I respect that you have the integrity to admit that ivermectin wasn’t able to prevent your illness.
1/
I’ve read the same studies & I disagree with your assessment of IVM; A few small methodologically flawed studies are just not compelling in light of negative results from large high quality RCTs.
@cochranecollab & many experts have likewise concluded that IVM is ineffective
2/
What I find alarming is your failure to use your platform to advocate for vaccination. You claim to follow the evidence. Do you really think there is more evidence for daily mouthwash use than for vaccination to prevent COVID?

3/
Read 9 tweets
9 Aug
A few weeks ago I tweeted about the rising cases due to #DeltaVariant. I was surprised by the number of people who replied saying essentially “they did this to themselves.”

A short 🧵about why we ought to look at this situation differently
1/
Seeing the #DeltaSurge among the un-vaccinated, I'm reminded of an adage I learned in my residency: “The trauma ICU is filled by man’s cruelty to man & the medical ICU by man’s cruelty to himself.”
2/
It’s true.

Without tobacco, alcohol, & opioids, there would be less COPD, cirrhosis, & endocarditis.

Without dietary indiscretions & "noncompliance”, we would not see fewer complications of DM or exacerbations of chronic illness.

But it's also not so simple.
3/
Read 16 tweets
1 Aug
Soo NEJM has an educational COVID critical care “game.” Obviously I had to play on expert.

First off let’s talk about the name: Bagel Mage?!?

I’m not one to criticize - my name is just two synonymous verbs - but Bagel Mage 🥯 🧙‍♀️ sounds like the lamest D&D character ever.

1/
Bagel’s hypotensive with sats in the mid 80s, better do a quick assessment & start someO2.

“May I ask about your goals in the event of a cardiac or respiratory arrest?”
- maybe the worst possible way to ask this but here it goes…

…Ok I guess he’s an everything bagel.
2/
No POCUS - guess I’ll do an exam & order some tests: ABG, basic labs, procalcitonin, CXR, some cultures, & a COVID test (you know “trust but verify”)

While I’m waiting I’ll order APAP, HFNC

Ugh oh. I guess im trouble for not coding enough. Damn this simulation is realistic!
3/
Read 24 tweets

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