Modern global economy & world trade are finely oiled interconnected machines near-perfectly calibrated for just-in-time delivery. #SARSCoV2 is a stumbling block in this machine. Like dominos, when one piece falls in some part of the world, everything starts falling apart.
1/
Governments misread this as a demand crisis & pushed the stimulus pedal to the metal pulling forward future & creating artificial, extra demand. Politicians wanted to compensate people for the mandated decrease in social activities & keep them happy for political purposes.
2/
But, I've said it many times: it's like a wheel has fallen off the car, yet you still keep pushing the accelerator. All you do is keep spinning in circles while risking blowing up the engine. The logical thing to do would be to fix the wheel FIRST before proceeding.
3/
Imagine if WWII was fought like this. That instead of spending on weapons & bullets, mobilizing everything & everyone, FDR & Churchill worried about people's happiness so gave money to them to buy dishwashers, TVs & cars (who & how would make those?) to enjoy themselves.
4/
#SARS2 is an unpredictable & uncontrollable disruptor (and a slow persistent long-term killer), so this pandemic is currently mainly a supply crisis. Demand shock was brief & similar to a natural disaster event. Soon, people just rerouted their consumption.
5/
Thus, we have a mismatch of glorious proportions in global supply & demand. Prices should go even higher to resolve that, but they can't because of shortages: it doesn't matter how much you're willing to pay if you can't get it. So, prices can't return us to equilibrium.
6/
It's the same for materials, goods & people/workforce. Nobody can finish anything started to build or produce. Everything's sold in advance.
There are two hard ways to solve this: confronting & dealing with #SARS2 instead of ignoring it or demand destruction a.k.a. recession.
7/
A third possible and an easy way is to muddle through & hope that in 2022 the pandemic ends on its own like the previous ones ended, supply chains slowly come back to normal, people return to work, while demand eases by tapering & slowing of stimulus.
8/
This third easy way rests on the hope of policymakers & virologists/scientists that #SARS2 is just like other common cold coronaviruses, or the flu at worst. That there is nothing special about it and everything will be fine once we all get infected by it. Good luck to us.
9/

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More from @x2IndSpeculator

27 Sep
I've been trying to combine daily Israel data with the @IsraelMOH FDA presentation & the booster study from @NEJM. Extending their ideas, I created charts that provide the same valuable real-life information as the study but CONTINUOUSLY in REAL-TIME.
1/
nejm.org/doi/pdf/10.105…
MOH correctly understood even a seemingly modest decrease in vaccine effectiveness results in a significant increase in relative risk for the vaccinated, impacting the pandemic control.
97%>85% = 5-fold increase in relative risk 3%>15% (1:33>1:6.6)
2/
fda.gov/media/152205/d… Image
So, to quantify the protective effect of the additional booster dose, it's best to compare rate ratios & calculate x-fold changes in relative risk.
"Protection is given as a fold reduction in risk relative to people who received only two vaccine doses."
3/
gov.il/BlobFolder/rep… Image
Read 29 tweets
18 Sep
I've been tweet-erratic the last few days because I thought my #SARS2 safety protocol has been breached. Like many other parents have experienced, it took us only seven days of this new living-with-#COVID school for my younger son to develop respiratory illness symptoms.
My guess, potential exposure was physical education (gym) class held INDOORS (& maskless) due to bad weather. Then, 36h later, a sore throat, fever, congested nose & cough. My wife & I are both x2 Pfizer post-3 months, and sons Pfizer 3 weeks after 1st dose (scheduled for 2nd).
After a couple of days of anxiety, surprisingly, I just got our #SARS2 negative test results. It seems my kid caught some other bug.
Since we managed to avoid close calls with #SARS2 for 20 months & stayed unusually healthy, this was my 1st firsthand experience with PCR testing.
Read 5 tweets
16 Sep
A great interview with @florian_krammer with several useful explanations about testing the levels of nAbs. My nightmare virus is #SARSCoV2, though. For 50% killers, the global reaction would be swift.
"Some antibody tests give you a yes-or-no response...
medscape.com/viewarticle/95…
That is okay to figure out if you had an infection or not, or if you made an immune response to the vaccine. But that's all it can tell you. Then there are antibody tests that are semi-quantitative or quantitative, that tell you what level of antibody you have now...
...these antibody tests are NOT MEASURING NEUTRALIZING ANTIBODIES; they're measuring BINDING antibodies. But...there's a relatively good correlation between neutralizing and binding antibodies... There isn't a single number above which...protected... it's usually a PROBABILITY."
Read 7 tweets
16 Sep
Is this the 1st time a company itself says its product is not good anymore but FDA says it is?
"Data from Israel suggest reduced effectiveness against SEVERE disease could eventually FOLLOW observed reductions in effectiveness against #SARSCoV2 INFECTIONS.
fda.gov/media/152161/d…
Moreover, reductions in effectiveness against infections could lead to increased transmission, especially in the face of the highly transmissible B.1.617.2 (#Delta) variant. Policymakers will need to continue to monitor VE over time and may need to consider recommendations for... Image
booster doses to restore initial high levels of protection observed early in the vaccination program, and to help control heightened transmission of B.1.617.2 (Delta) as we enter the upcoming fall/winter viral respiratory season."
FDA unimpressed, though:
fda.gov/media/152176/d…
Read 4 tweets
15 Sep
I'm sorry but I can't stand anymore these simplified charts with selected time frames & selected subgroups & equalized y-axis for cases, severe & deaths to minimize damage from #SARS2 & wrong assertion naturally infected are only among unvaccinated... like just published in FT.
My philosophy is:
Find .csv or .xls data from an official trusted source.
Plot a chart from DAY 1 of the provided dataset.
Show ALL available subgroups; comparison is vital, especially if using incidences.
If combining deaths & cases use LOG charts because linear diminish deaths!
After I import & consolidate data, creating a new chart is a truly exciting exploration moment for me. I go where it leads me.
The mainstream media's half-charts are not exploratory. They serve to confirm predestined presumptions of its authors/editors & justify someone's policy.
Read 4 tweets
14 Sep
A continuation of NIH studies on macaques; this one trying to solve a riddle of differences in #COVID severity & immune response between the young & the old.
@fitterhappierAJ
"Aging results in numerous changes to cells & mediators of the immune system... biorxiv.org/content/10.110…
which alter susceptibility to infection, disease progression & clinical outcomes...
immunosenescence include cytokine dysregulation, an accumulation of senescent cells leading to chronic inflammation, a loss of naïve T- & B-cells & defective responses by innate immune subsets."
"Declining adaptive immunity is another hallmark of immunosenescence. A reduction in thymic & bone marrow function contributes to a loss of naïve T- and B-cells & the accumulation of terminally differentiated effector cells...
older rhesus macaques exhibited lower frequencies...
Read 6 tweets

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