Share this page!

Hannah Davis 🌈 Profile picture
Twitter logo
12 Oct, 5 tweets, 3 min read
I've started to hear cases of people who got COVID twice - who recovered the 1st time, but got #LongCovid the 2nd.

This is in line with everything we know about infectious-onset conditions. The body cannot sustain hit after hit to the immune system without consequences.

1/
We saw reinfections start happening last summer for the first wavers. The research below shows reinfections could happen as early as 4 months after infection. 2/

In endemic conditions, reinfection would likely happen after about 1.5 years.


3/
People with #LongCovid have dysfunctional T cell responses, they have decreasing NK cell functionality - these aren't things that just go away. These are things that will make people worse with subsequent hits. We know that many #pwME get worse after each subsequent infection. 4/
So learning about understanding reinfections is one of the biggest priorities for us to make good policy decisions - both for people with #LongCovid who are already sick, and for people who were safe the first time but are unknowingly primed to get #LongCovid on reinfection.

5/

• • •

Missing some Tweet in this thread? You can try to force a refresh
　

Keep Current with Hannah Davis 🌈

Hannah Davis 🌈 Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @ahandvanish

Hannah Davis 🌈 Profile picture
6 Oct
The WHO's Clinical Case Definition for #LongCovid is up!

Symptoms include fatigue, shortness of breath, cognitive dysfunction, memory issues, post-exertional malaise, menstrual & period problems, altered smell/taste, blurred vision, chest pain, dizziness, intermittent fever...1/
cough, gastrointestinal issues (diarrhea/constipation/acid reflux), abdominal pain, headache, joint pain, muscle pain/spasms, neuralgias, new onset allergies, pins & needles sensations, depression, sleep disorders, tachycardia/palpitations, anxiety, tinnitus & hearing issues.
2/
The larger description and process is published here:
apps.who.int/iris/bitstream…

#LongCovid

3/
Read 4 tweets
Hannah Davis 🌈 Profile picture
2 Oct
Turning a Corner in ME/CFS Research: mdpi-res.com/d_attachment/m… #pwME #LongCovid

ME/CFS is a multi-system disorder, with dysregulation of the HPA axis and of metabolism of the central nervous system and of body systems generally. The range of abnormal responses includes:

1/ Image
-alteration of autonomic nervous system function
-lasting adaptations in energy metabolism and the immune response
-orthostatic intolerance with reduction in cerebral blood flow on tilt testing
-variations in cortisol levels associated with increased fatigue. #pwME

2/
-disorganized circadian rhythms
-increased immune system activation as shown for example by increased pro-inflammatory cytokines and prolonged inflammatory responses
-alterations in muscle anaerobic threshold
-abnormal recovery after activity with post-exertional malaise
#pwME
3/
Read 5 tweets
Hannah Davis 🌈 Profile picture
23 Sep
I feel bad for everyone who was exploited in this article. The blame obviously lies with the author; I can't get over the fact that there are people willing to try to discredit the experiences of millions of people, in exchange for some funding behind the scenes.

But...

1/
I also think there were advocacy gaps that allowed this to happen. And I feel frustrated, because this harms our whole movement.

I hope #LongCovid groups take away a few lessons from this, including:

Advocates must be historically informed. There's a long history of...

2/
discrediting virus- and infection-initiated illnesses, in many cases starting with articles just like these. This happens constantly in ME & Lyme & happened early on with AIDS & other illnesses, & has started ramping up with #LongCovid.

3/
Read 14 tweets
Hannah Davis 🌈 Profile picture
31 Aug
Let's talk about...herpesviruses! And other reactivations in #LongCOVID.

When most people hear "herpesvirus" they think of STDs. But herpesviruses are a virus family, like coronaviruses.

Mono is a herpesvirus. So are shingles & chicken pox. All humans have at least one!

1/
Less familiar herpesviruses include: Cytomegalovirus (CMV, which ~50% of people have by age 40), Human-Herpesvirus-6 (HHV-6, which ~100% of people have), and Human-Herpesvirus-8 (HHV-8).

(Side note that this is all an explanation for laypeople, so I'll be simplifying a bit.)

2/
Herpesviruses are lifelong infections, but are usually latent, meaning they aren't "active". When the immune system is healthy, most people can keep them at bay. During times of illness/stress or in response to certain triggers (food, heat, hormones), these can flare up.

3/
Read 12 tweets
Hannah Davis 🌈 Profile picture
30 Aug
New CDC study finds that 36% of COVID patients *never seroconvert*, meaning they NEVER make antibodies! #LongCovid

This is a huge finding which we need to amplify broadly! Please retweet & send to providers, patients, support groups, #MedTwitter, etc.

wwwnc.cdc.gov/eid/article/27…
1/
They found two major risk factors that predicted a lack of seroconversion:

A) Age: people under 40 are statistically less likely to make antibodies. #LongCovid

2/
B) Small viral load: people who had higher PCR Ct values (meaning the test had to run more cycles before returning positive) were also less likely to seroconvert. This implies mild and asymptomatic cases are less likely to seroconvert. #LongCovid

3/ Image
Read 7 tweets
Hannah Davis 🌈 Profile picture
28 Aug
This age-adjusted data from Israel shows a deep decrease in vaccine effectiveness against symptomatic COVID infection for people who got vaccinated in January-February. #LongCovid

1/ Image
This was measured 2 months ago. Now that it's almost Sept, vaccine effectiveness for those vaccinated in April is likely close to the Feb numbers here.

And in the past few weeks, we've started seeing more breakthroughs from people who got vaccinated in April. #LongCOVID

2/
h/t @DanOfAmerica!
Read 4 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!

Like this author's thread?

Get emails when @ahandvanish has new unrolls!

Check out other threads from @ahandvanish!

Read all threads by @ahandvanish

:(