Just HOW effective are the COVID-19 vaccines at protecting you from severe illness and hospitalization even in the face of Delta?
BEFORE Delta variant increase: 95% effective
DURING Delta variant increase: 92% effective
Answer: VERY EFFECTIVE
Let’s discuss. 🧵
Real-world data out of King County, WA (which includes Seattle) confirms vaccinated individuals are significantly better protected from illness, hospitalization, AND death due to COVID-19 compared to unvaccinated individuals, even as the Delta variant surges through the state.
Over the PAST 30 days, unvaccinated individuals were:
•9X more likely to test positive for COVID-19 (65% of cases)
•48X more likely to be hospitalized for COVID-19 (77% of hospitalizations)
•69X more likely to die of COVID-19 related illness (74% of deaths)
Charts measuring COVID-19 between the two groups show a sharp, unrelenting increase in unvaccinated cases in Washington in August and September while vaccinated cases peaked on August 10th before again declining. Over the last month, fully vaccinated cases NEVER exceeded 13 cases
per 100,000 residents, a high reached on August 10th, before again declining, while unvaccinated cases continued to climb through the month, now topping at 88 cases per 100,000 people around October 1st. You can find the dashboard here: kingcounty.gov/depts/health/c…
Another set of real-world data comes out of Connecticut. Data as of October 14th shows unvaccinated individuals were:
•5X more likely to test positive for COVID-19 (73% of cases in the past 7 days)
•74X more likely to be hospitalized for COVID-19
•11X more likely to die of COVID-19 related illness
You can find the dashboard here: portal.ct.gov/-/media/Corona… which does provide case demographics.
A July 2021 study of Los Angeles, California public health records found unvaccinated individuals had 5X more COVID-infections than vaccinated individuals AND had 29X more COVID-19 hospitalizations than fully vaccinated individuals.
The Delta variant became the predominant variant in Los Angeles County during May-July 2021. During this period, SARS-CoV-2 cases and hospitalizations increased substantially, most notably amongst unvaccinated individuals: cdc.gov/mmwr/volumes/7…
Another study, this time out of New York shows the current COVID-19 vaccines were highly effective against hospitalization (VE >90%) for fully vaccinated New York residents, even during a period during which prevalence of the Delta variant increased from
<2% to >80% in the U.S. region that includes New York, societal public health restrictions eased, AND adult full-vaccine coverage in New York neared 65%. You can read more here: cdc.gov/mmwr/volumes/7…
Lastly, data out the Indiana Department of Health. For the week of September 30th, there were 1,447 new COVID-19 hospital admissions. LESS THAN 15 of those were vaccinated individuals. You can find their dashboard here: coronavirus.in.gov/vaccine/2680.h…
The CDC is NOW posting national data on vaccination status for hospitalization and death due to COVID-19 and it IS stratified by age. In August unvaccinated individuals were:
•6X more likely to test positive for COVID-19
•11X more likely to die of COVID-19 related illness
You can find this information here: covid.cdc.gov/covid-data-tra…. Even in the face of the Delta variant, these vaccines are indeed effective against preventing symptomatic infection, severe disease, hospitalization AND death due to COVID-19.
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Just a friendly reminder. Despite what you might hear, there has yet to be a variant that isn’t susceptible to the vaccines.
Why are variants unlikely to FULLY evade vaccine-induced immunity?
•Vaccines are polyclonal
•CD8+ T-cells covering 52 epitopes across the spike protein
•CD4+ T-cells covering 23 epitopes across the spike protein
You can learn about epitopes here: news-medical.net/life-sciences/…
Regarding the concerns about waning immunity. Please remember, this is likely referring to infection. Not effectiveness against symptomatic infection, not effectiveness against severe illness. See: bmj.com/content/374/bm…
This is what we have been waiting for! A study out of NIH shows heterologous COVID-19 booster vaccinations of Moderna, Pfizer, and Johnson & Johnson induce strong humoral immune responses (up to a 76X increase in nAbs) with acceptable reactogenicity profiles. Let’s discuss. 🧵
This particular study involved 458 participants. They were divided into nine groups with roughly around 50 participants in each group. Those who initially got Moderna’s vaccine got either another dose of Moderna, a dose of Pfizer, or a dose of Johnson & Johnson as a booster four
to six months after their primary immunization. Those who got Pfizer’s vaccine got either another dose of Pfizer or a dose of Moderna or a J&J booster. And those who received one dose of J&J initially either got another dose of J&J or a Moderna or Pfizer booster dose.
After 548 days of restrictions to limit the spread of COVID-19, Denmark's high vaccination rate has enabled the country to become one of the first European Union nations to lift ALL domestic health measures. More than 85% of the eligible Danish population is fully vaccinated. 🧵
The return to normality has been gradual, but as of October 8th, the digital pass- proof of having been vaccinated- is no longer required when entering nightclubs, making it the LAST virus safeguard to fall. The Danish government NO LONGER considers COVID-19
a socially critical disease. “Denmark is lifting the restrictions because the vaccine rollout has been very successful," said Jens Lundgren, Professor of Viral Diseases, Copenhagen University Hospital. “As a consequence, we have the pandemic under control in this country and can
An analysis of ~250,000 in Canada found two doses of any of the three COVID-19 vaccines (Moderna, Pfizer, AstraZeneca) led to strong protection from infection, hospitalization, AND death -even against Delta- REGARDLESS of the vaccination combination and showed NO signs of waning.
Preliminary data from researchers at the British Columbia Centre for Disease Control (BCCDC) and the Quebec National Institute of Public Health (INSPQ) shows the decision to vaccinate more Canadians sooner by delaying second shots by up to four months saved lives.
The researchers excluded long-term care residents from the data, who are generally at increased risk of hospitalization and death from COVID-19, in order to get a better sense of vaccine effectiveness in the general population. Needless to say the results were exceptional.
Yes, the vaccines ARE effective against the Delta variant. Yes, you will want both doses for maximum protection. Yes, they’re effective against preventing symptomatic infection, severe disease, AND hospitalization. Several studies have proven this now. Stop the misinformation.
Also, yes, this does include Johnson & Johnson. Why are variants unlikely to FULLY evade vaccine-induced immunity?
•Vaccines are polyclonal (Abs)
•CD8+ T-cells covering 52 epitopes across the spike protein
•CD4+ T-cells covering 23 epitopes across the spike protein
“Breakthrough” infections DO NOT mean vaccines don’t work. Remember, they are preventives, NOT cures. One can still contract COVID once vaccinated. As long as that vaccine is preventing you from facing severe disease and worse, it IS working and doing what it was designed to do.
Regarding the concerns about waning immunity. Please remember, this is likely referring to infection. NOT effectiveness against symptomatic infection, NOT effectiveness against severe illness. While neutralizing antibodies decrease over time (as they ARE supposed to) protective
immunity provided by memory B-cells and T-cells is STILL present. Remember: Immunological memory consists of antibodies, memory B-cells, memory CD8+ T-cells, and memory CD4+ T-cells. These responses give us enduring protection even against newly emerging SARS-CoV-2 variants.