1/ One of the biggest challenges in discussing these tough topics is that it can sometimes have a greater polarization effect on those listening.

I want to reiterate (as I have many times) that I strongly appreciate @ethanjweiss and our many great conversations public & private
2/ Our last conversation on @chadinabhan’s podcast certainly stirred a lot of emotion, and in that sense, it was unusual given our typical rapport.

But regardless, I have and continue to hope we can move forward with a mutual interest toward cordial conversation.
3/ As a rule, I generally avoid criticizing behavior of others given it creates a standard of perpetual policing.

That said, I’d like to ask a personal favor. I’d love if there were less personal attacks on all sides— particularly to @ethanjweiss
4/ He’s a husband, proud father, and a great doctor. Whatever our differences, we have a very cordial relationship and I literally just DMed him a few days ago that I wish a happy Thanksgiving to him and his family.

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More from @DaveKeto

21 Nov
1/ I want to take a moment to have a back-and-forth exchange with @MichaelMindrum in a thread, and I’m just gonna keep it to us (Tweet setting) I’m confident we can keep it productive. 👍

First, I think we should get on the same page with where I’m coming from..
2/ I’m not just interested in high LDL for LMHRs. I’m interested in whether it’s meaningful to distinguish high LDL from what appears to be lipid metabolic dysregulation versus high LDL in the context of metabolic fat adaptation.
3/ Much of those following this account know this already from following my work, but often critics do not.

That’s why I’d love to specificity talk to a critic I like, such as yourself, and really unpack this so we can better narrow down where the real disagreements are.
Read 9 tweets
21 Nov
1/ this one minute clip was released by @chadinabhan an hour ago, and when I watched it I got a bit concerned that it takes a clip out of context and DMed Chadi about it.

He rightly pointed out my reaction was misplaced as this was strictly a teaser.
2/ However, this did provide me an opportunity to expand on the point, given I understand where @ethanjweiss would feel this was “meaningful”.

In our exchange from several months ago (too lazy to link), Ethan pressed as to whether I’d take a statin post heart attack…
3/ I said then (and I’ll say today) – I don’t know, but I feel it would be irresponsible for me to say one way or another.

But what came up in this podcast, is it would be meaningful to Ethan if I pointed out that post MI-research I’d see a scenario where I would.
Read 6 tweets
14 Nov
🚨🚨🚨BREAKING - $20k Analysis Effort🚨🚨🚨
1/2

Since my tweet last night, a donor has now come forward looking to fund 👉👉👉$20,000👈👈👈 toward this effort for publication!!! 🤯🤯🤯

Reaching out to any #DataScientist who is serious about making this happen.

(See next 👇)
2/2
👉👉👉 Here's our newly released post on this project: cholesterolcode.com/announcement-2…

If you're like me and feel this is waaaaay overdue, please help us find the Rockstar(s) who can make this a reality!
Hey #UnitedKingdom docs like @lowcarbGP and @DrScottMurray -- know anyone data scientists on #UKBiobank who'd be interested in this project? 👆👆👆
Read 4 tweets
3 Nov
1/ This is especially important timing.

As many of you know, we're conducting a study on #LMHRs (link later in thread) who not only have extremely high #LDL #Cholesterol, but many (likely most) have diets quite contrary to this advice by the @American_Heart.

Let's unpack...
2/ First, and most importantly, we do not know what the outcome of this prospective study is. So while I'll be outlining commonalities we observe with #LMHRs, this isn't an explicit endorsement of the diet nor any altered lipid levels as a result.

With that said...
3/ We have a lot of data between our standing survey, submissions to CholesterolCode.com, and CC and LMHR Facebook groups (7.7k and 7.5k members, respectively).

Diets are often:
1) Low to no fruits & veg
2) Low to no grains
3) High animal protein
4) Low in plant oils
Read 6 tweets
22 Oct
1/ 👉 "HDL Triglycerides"
or rather HDL-TG
-- As in, triglycerides onboard HDL particles

↗️ Highly associated with: total TG, glycerol, fatty liver index. ↘️Opposite w/ HDL-C/-P

And ofc 👉"Patients with carotid plaques also showed higher HDL-TG."...

pubmed.ncbi.nlm.nih.gov/31252694/
2/ @josefagirona, @lluismasana et al conclude the abstract with:

"HDL-TG should be considered a biomarker of metabolic and cardiovascular risk and could be a marker of HDL dysfunction."

If I can offer a different hypothesis (again, consistent with the #LipidEnergyModel)...
3/ Consider these HDL particles with higher levels of triglycerides aren't really that unique.

They more likely a downstream result of metabolic dysfunction as opposed to a distinct species of particle.
Read 8 tweets
12 Oct
1/ Posting this hypothesis for posterity:

I now suspect #PlantBasedLowCarb (PBLC) isn't as low carb as originally thought.

Before getting started in this thread, I should emphasize I wouldn't consider this a good or bad thing in and of itself, but it is of interest, ofc... Image
2/ Moreover, I've regularly pointed to people following my work who are both (1) very interested in a low carb diet, but (2) would prefer to keep their #LDL low to consider PBLC as a "third option", as I commonly see it associates with this outcome.

Now to my hypothesis...
3/ PBLC generally has two major features separating it from "typical" #keto/#lchf:

1) More fat sourced from mono and polyunsaturated fatty acids (M/PUFA) instead of saturated fatty acids (SFA)

2) A lot more soluble and insoluble fiber via plants
Read 11 tweets

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