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Eric Feigl-Ding Profile picture
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15 Dec, 5 tweets, 3 min read
Don’t count on monoclonal antibody drugs to save you—German researchers have found that #COVID19 synthetic antibody therapies developed by Eli Lilly and Regeneron lose most of their effectiveness when exposed in laboratory tests to the #Omicron variant.
reuters.com/business/healt…
2) While many drugs work, I don’t think they will end the pandemic. Stopping transmission and opportunities for mutation will be what saves us in the end. Not just milder cases with expensive pharma treatment.
3) Many monoclonal antibody drugs are now in trouble against #Omicron
4) not all vaccines created alike. And not all vaccines have the same neutralization capacity against #Omicron — see detailed thread 🧵 below… 👇
5) Let this sink in — if convalescent blood from #COVID19 survivors can’t even neutralize #Omicron well, then do you really think monoclonal antibodies will be the magic cure? Don’t rely on MABs — vaccinate and get boosted and wear masks and ventilate.

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More from @DrEricDing

Eric Feigl-Ding Profile picture
16 Dec
The #Omicron variant is surging in the US exponentially… CDC data shows that New York / New Jersey region is now over 10% Omicron of all #COVID19 cases. The rest of US is not far behind—likely dominant by Christmas 🎄 — please be careful during holidays.

Figure by @DrWilliamKu. Image
2) I’m glad that NYC will be distributing free COVID tests and KN95 masks. Thank you @NYCHealthCommr @davechokshi!
3) NYC positivity has doubled in just 2 days. That’s bad bad bad. Image
Read 5 tweets
Eric Feigl-Ding Profile picture
15 Dec
📍The coronavirus is airborne. Very airborne. Even if you don’t see anyone—doesn’t mean the aerosols aren’t in the air. WATCH📺

➡️ you need high quality N95 / KN95 / KF94 / FFP2/ FFP3 masks.

➡️ also please ventilate, get HEPA filters, get upper room UV.
2) VENTILATION is key. Both ventilation and masks needed to reduce risk indoors. But most buildings not ventilated well enough.

3) AEROSOLS ARE AIRBORNE.

“Until we recognise that #COVID19 is airborne we are setting ourselves up for repeated failure”
Read 7 tweets
Eric Feigl-Ding Profile picture
15 Dec
💡New VACCINE RANKING of ability to neutralize #Omicron—Moderna appears to be the strongest against Omicron in this study, but still big drop. Pfizer next best (but we know infection efficacy is 30-34%), AstraZeneca & Sinopharm poor. J&J & Sputnik = zero.🧵biorxiv.org/content/10.110… Image
2) Natural infection immunity is on the left … “convalescent” = practically no neutralization against #Omicron in this study by itself without vaccine. Image
3) Meanwhile for SinoVac —one of the world’s most widely used vaccines, doesn’t provide sufficient antibodies to neutralize the #omicron variant, said 🇭🇰 researchers. But a 3rd shot booster seemed up help. bloomberg.com/news/articles/…
Read 13 tweets
Eric Feigl-Ding Profile picture
15 Dec
HIGHEST kids COVID hospitalization ever in England 🏴󠁧󠁢󠁥󠁮󠁧󠁿 of the whole pandemic… ➡️ But but but… I thought some politicians & economist had once said “kids are practically immune” to #COVID19. 🤦🏻‍♂️
2) Kids are known transmitters. They are not just like vaccinated adults. Kids are kids. Every hospitalization is a tragedy.
3) a 3 million person Danish study shows more kids in a household, more transmission. This is why we need to vaccinate to both protect kids and protect others in the household.
Read 10 tweets
Eric Feigl-Ding Profile picture
14 Dec
BREAKING—Largest study of 2-shot Pfizer vaccine effectiveness against #Omicron from largest health insurer in 🇿🇦:

📌33% VE against #Omicron (symptomatic?) infection

📌70% VE against #Omicron hospitalization (93% against #DeltaVariant before in 🇿🇦)

➡️Urgently need boosters.🧵
2) the new study also mentions 20% greater risk of hospitalization among kids with #Omicron compared to an older strain last year.
3) Also, the protective effects of prior infection has waned and further erode by #Omicron. ➡️ Bottomline: don’t rely on past infection immunity!
Read 13 tweets
Eric Feigl-Ding Profile picture
14 Dec
📌 “Omicron is mild” dismissiveness = same energy as the “It’s just the flu” downplaying from Jan-March 2020. Learn from history. Don’t repeat it.

HT @danaparish #Omicron #COVID19
2) Exponential surge in cases is what will kill more people in the end. And while boosters work against #Omicron, the rollout of boosters wont be able to keep up with the exponential rise. We need to do more ASAP. See thread 🧵 below.
3) Anyone who touts “Omicron is milder” (not proven) also doesn’t understand epidemiology and exponential math. Even if it is 1/10th deadlier, but just merely 2x more contagious (we think #Omicron is 4-6x more), more people will die even with the 1/10th milder virus. See 🧵below
Read 4 tweets

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