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Dave Feldman Profile picture
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Jan 19 • 10 tweets • 3 min read
1/ One of the toughest skills to master is avoiding sarcasm save those moments where you're pretty sure it will be well received by almost everyone.

Occasionally, I do a self check to see how that's going. Gotta say, I'm pretty pleased with some of the most recent ones...
2/ Everyone can related to the "I'm doing Diet X..." challenge. This one from May...

3/ This one is my trolling the trolling. 😂

4/ See whole thread to get the joke...

5/ These next ones are more just puns and/or lame humor (mostly "and")...

6/

7/
8/

9/ Okay, but seriously, there are many times I think of something to say online that sounds humorous in the moment, but on deeper thought I realize could come off as hurtful or mean. Sarcasm can be on of the easiest ways to trick yourself into assuming it is more valid to express
10/ ... Obviously, this is very much contextual, but I'd offer it's usually well worth the second, third, or tenth thought. If you can easily see how someone would be offended by a sarcastic remark, it might be worth finding a better way to say it -- or just not saying it at all.

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More from @realDaveFeldman

Dave Feldman Profile picture
Dec 23, 2021
1/ #ReminderThread -

One thing that still surprises me is when I'm tweeting or retweeting opinion, articles, etc that are generally pro #LDL #Cholesterol-lowering or LDL-as-problematic (such as recently) I get some pushback...
2/ If you've followed me a long time, you should know this is something I'm proactive about doing -- in fact, I'm more active at doing it now than ever.

If you've only heard the ⬆️LDL isn't-so-bad case, please hear out the mainstream case on how ⬆️LDL *is* bad...
#NoEchoChambers
3/ If you somehow hadn't already heard, I literally spearheaded a crowdfunding campaign for an IRB-approved study with longitudinal CCTAs to track plaque development

Why? Because we don't know what the risk levels are for this context. If we did, there'd be no need for the study
Read 11 tweets
Dave Feldman Profile picture
Dec 22, 2021
1/ Yes, will comment on it in time as I have some follow up questions and comments -- but for the moment, I want to reemphasize how much I appreciate @deirdre_tobias publishing the baseline charts, making the code available, and overall devoting her time to this project...
2/ Seeing this progress and unfold over a matter of weeks is fantastic. I'm used to either getting a "sneak preview" of what an analysis might show with a given dataset or be told it will require full publication (many months and dollars down the road) in order to be public...
3/ In other words, I wish we could get this kind of turnaround and transparency on every major dataset. @deirdre_tobias has effectively done something I've been asking after for years -- and she did so at no cost.

That's worth its own distinction and one I certainly laud.
Read 4 tweets
Dave Feldman Profile picture
Dec 17, 2021
1/ Yes -- if you're curious as to why @nicknorwitz and I are chatting so often about ANGPTLs, it's worth working our way backwards...

If you're powered by fat, your tissues are getting it from free fatty acids or triglycerides (which is really three FAs bundled together)...
2/ Recently I was much more focused on fasting (see ) and lipoprotein lipase (LPL) dynamics (see ) Image
3/ And indeed, the regulatory strings behind LPL up and down regulation is a much bigger part of the story with regard to VLDL turnover -- and thus potential resulting effects on LDL-C, HDL-C, and Triglycerides (TG).
Read 5 tweets
Dave Feldman Profile picture
Dec 13, 2021
1/ If you want to hear a great discussion on the #LMHRstudy from my colleague,@DrNadolsky (who is most definitely pro-#LDL #Cholesterol lowering), I highly recommend this podcast that just dropped via @Plant_proof.

I'll add just a few quick thoughts...
2/ Firstly, this may be the most I've heard myself talked about in a podcast I wasn't in (😂 weird, but understandable given the context).

But while certainly critical in many respects, I felt both @DrNadolsky and @Plant_proof provided a lot of good context...
3/ @DrNadolsky bring up my oft-repeated phrase, "cautiously optimistic" [in the context of higher LDL/ApoB as a seemingly resulting from metabolic fat-adaption]

Worth repeating that mine is a hypothesis and should be treated as such, hence the "cautious" part of the phrase...
Read 8 tweets
Dave Feldman Profile picture
Nov 24, 2021
1/ One of the biggest challenges in discussing these tough topics is that it can sometimes have a greater polarization effect on those listening.

I want to reiterate (as I have many times) that I strongly appreciate @ethanjweiss and our many great conversations public & private
2/ Our last conversation on @chadinabhan’s podcast certainly stirred a lot of emotion, and in that sense, it was unusual given our typical rapport.

But regardless, I have and continue to hope we can move forward with a mutual interest toward cordial conversation.
3/ As a rule, I generally avoid criticizing behavior of others given it creates a standard of perpetual policing.

That said, I’d like to ask a personal favor. I’d love if there were less personal attacks on all sides— particularly to @ethanjweiss
Read 4 tweets
Dave Feldman Profile picture
Nov 21, 2021
1/ I want to take a moment to have a back-and-forth exchange with @MichaelMindrum in a thread, and I’m just gonna keep it to us (Tweet setting) I’m confident we can keep it productive. 👍

First, I think we should get on the same page with where I’m coming from..
2/ I’m not just interested in high LDL for LMHRs. I’m interested in whether it’s meaningful to distinguish high LDL from what appears to be lipid metabolic dysregulation versus high LDL in the context of metabolic fat adaptation.
3/ Much of those following this account know this already from following my work, but often critics do not.

That’s why I’d love to specificity talk to a critic I like, such as yourself, and really unpack this so we can better narrow down where the real disagreements are.
Read 9 tweets

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