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17 Dec, 5 tweets, 3 min read
1/ Yes -- if you're curious as to why @nicknorwitz and I are chatting so often about ANGPTLs, it's worth working our way backwards...

If you're powered by fat, your tissues are getting it from free fatty acids or triglycerides (which is really three FAs bundled together)...
2/ Recently I was much more focused on fasting (see ) and lipoprotein lipase (LPL) dynamics (see ) Image
3/ And indeed, the regulatory strings behind LPL up and down regulation is a much bigger part of the story with regard to VLDL turnover -- and thus potential resulting effects on LDL-C, HDL-C, and Triglycerides (TG).
4/ Enter @nicknorwitz who quickly expanded on this crucial aspect of the #LipidEnergyModel/#LEM (among many other aspects) and we connect the extremely relevant ANGPTLs of 3, 4, and 8. Check in on his feed for many fantastic insights as he's been covering it in real time...
5/ But in short, the key component with ANGPTLs as they relate to #LEM is in their elegant interplay for tissue-specific triglyceride uptake from ApoB lipoproteins.

👉 They achieve higher TG uptake into fat stores when fed, higher TG uptake into oxidative tissues when fasting.

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More from @realDaveFeldman

Dave Feldman Profile picture
13 Dec
1/ If you want to hear a great discussion on the #LMHRstudy from my colleague,@DrNadolsky (who is most definitely pro-#LDL #Cholesterol lowering), I highly recommend this podcast that just dropped via @Plant_proof.

I'll add just a few quick thoughts...
2/ Firstly, this may be the most I've heard myself talked about in a podcast I wasn't in (😂 weird, but understandable given the context).

But while certainly critical in many respects, I felt both @DrNadolsky and @Plant_proof provided a lot of good context...
3/ @DrNadolsky bring up my oft-repeated phrase, "cautiously optimistic" [in the context of higher LDL/ApoB as a seemingly resulting from metabolic fat-adaption]

Worth repeating that mine is a hypothesis and should be treated as such, hence the "cautious" part of the phrase...
Read 8 tweets
Dave Feldman Profile picture
24 Nov
1/ One of the biggest challenges in discussing these tough topics is that it can sometimes have a greater polarization effect on those listening.

I want to reiterate (as I have many times) that I strongly appreciate @ethanjweiss and our many great conversations public & private
2/ Our last conversation on @chadinabhan’s podcast certainly stirred a lot of emotion, and in that sense, it was unusual given our typical rapport.

But regardless, I have and continue to hope we can move forward with a mutual interest toward cordial conversation.
3/ As a rule, I generally avoid criticizing behavior of others given it creates a standard of perpetual policing.

That said, I’d like to ask a personal favor. I’d love if there were less personal attacks on all sides— particularly to @ethanjweiss
Read 4 tweets
Dave Feldman Profile picture
21 Nov
1/ I want to take a moment to have a back-and-forth exchange with @MichaelMindrum in a thread, and I’m just gonna keep it to us (Tweet setting) I’m confident we can keep it productive. 👍

First, I think we should get on the same page with where I’m coming from..
2/ I’m not just interested in high LDL for LMHRs. I’m interested in whether it’s meaningful to distinguish high LDL from what appears to be lipid metabolic dysregulation versus high LDL in the context of metabolic fat adaptation.
3/ Much of those following this account know this already from following my work, but often critics do not.

That’s why I’d love to specificity talk to a critic I like, such as yourself, and really unpack this so we can better narrow down where the real disagreements are.
Read 9 tweets
Dave Feldman Profile picture
21 Nov
1/ this one minute clip was released by @chadinabhan an hour ago, and when I watched it I got a bit concerned that it takes a clip out of context and DMed Chadi about it.

He rightly pointed out my reaction was misplaced as this was strictly a teaser.
2/ However, this did provide me an opportunity to expand on the point, given I understand where @ethanjweiss would feel this was “meaningful”.

In our exchange from several months ago (too lazy to link), Ethan pressed as to whether I’d take a statin post heart attack…
3/ I said then (and I’ll say today) – I don’t know, but I feel it would be irresponsible for me to say one way or another.

But what came up in this podcast, is it would be meaningful to Ethan if I pointed out that post MI-research I’d see a scenario where I would.
Read 6 tweets
Dave Feldman Profile picture
14 Nov
🚨🚨🚨BREAKING - $20k Analysis Effort🚨🚨🚨
1/2
Since my tweet last night, a donor has now come forward looking to fund 👉👉👉$20,000👈👈👈 toward this effort for publication!!! 🤯🤯🤯

Reaching out to any #DataScientist who is serious about making this happen.

(See next 👇)
2/2
 👉👉👉 Here's our newly released post on this project: cholesterolcode.com/announcement-2…

If you're like me and feel this is waaaaay overdue, please help us find the Rockstar(s) who can make this a reality!
Hey #UnitedKingdom docs like @lowcarbGP and @DrScottMurray -- know anyone data scientists on #UKBiobank who'd be interested in this project? 👆👆👆
Read 4 tweets
Dave Feldman Profile picture
3 Nov
1/ This is especially important timing.

As many of you know, we're conducting a study on #LMHRs (link later in thread) who not only have extremely high #LDL #Cholesterol, but many (likely most) have diets quite contrary to this advice by the @American_Heart.

Let's unpack...
2/ First, and most importantly, we do not know what the outcome of this prospective study is. So while I'll be outlining commonalities we observe with #LMHRs, this isn't an explicit endorsement of the diet nor any altered lipid levels as a result.

With that said...
3/ We have a lot of data between our standing survey, submissions to CholesterolCode.com, and CC and LMHR Facebook groups (7.7k and 7.5k members, respectively).

Diets are often:
1) Low to no fruits & veg
2) Low to no grains
3) High animal protein
4) Low in plant oils
Read 6 tweets

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