1/ If you want to hear a great discussion on the #LMHRstudy from my colleague,@DrNadolsky (who is most definitely pro-#LDL#Cholesterol lowering), I highly recommend this podcast that just dropped via @Plant_proof.
2/ Firstly, this may be the most I've heard myself talked about in a podcast I wasn't in (😂 weird, but understandable given the context).
But while certainly critical in many respects, I felt both @DrNadolsky and @Plant_proof provided a lot of good context...
3/ @DrNadolsky bring up my oft-repeated phrase, "cautiously optimistic" [in the context of higher LDL/ApoB as a seemingly resulting from metabolic fat-adaption]
Worth repeating that mine is a hypothesis and should be treated as such, hence the "cautious" part of the phrase...
4/ Or to be a bit more explicit -- we may well find there is considerable increase in non-calcified plaque for these LMHRs and borderline LMHRs within this study. This is definitely something I consider possible, hence the intense interest to find out either way.
5/ @Plant_proof mentions people can also consider a more #plantbased#lowcarb approach as it tends to associate with lower LDL, and FWIW, I tweet and retweet on this often. (search #PlantBasedKeto in my history to find tweets like these:
6/ I'm particularly proud of @DrNadolsky making the crucial case as to why we need to get this data from a pro-#LipidHypothesis perspective.
We're finally gathering data on the phenomenon in low carb that was debated long before I began this diet or began researching lipids.
7/ I did want to add a quick correction for my good friend, Spence -- the "gym hypothesis" hypothetical of converting lean folks to LMHRs isn't agnostic of the type of low carb (re M/PUFA), it's more about demonstrating the outcome as less likely genetic.
1/ I want to take a moment to have a back-and-forth exchange with @MichaelMindrum in a thread, and I’m just gonna keep it to us (Tweet setting) I’m confident we can keep it productive. 👍
First, I think we should get on the same page with where I’m coming from..
2/ I’m not just interested in high LDL for LMHRs. I’m interested in whether it’s meaningful to distinguish high LDL from what appears to be lipid metabolic dysregulation versus high LDL in the context of metabolic fat adaptation.
3/ Much of those following this account know this already from following my work, but often critics do not.
That’s why I’d love to specificity talk to a critic I like, such as yourself, and really unpack this so we can better narrow down where the real disagreements are.
1/ this one minute clip was released by @chadinabhan an hour ago, and when I watched it I got a bit concerned that it takes a clip out of context and DMed Chadi about it.
He rightly pointed out my reaction was misplaced as this was strictly a teaser.
As many of you know, we're conducting a study on #LMHRs (link later in thread) who not only have extremely high #LDL#Cholesterol, but many (likely most) have diets quite contrary to this advice by the @American_Heart.
2/ First, and most importantly, we do not know what the outcome of this prospective study is. So while I'll be outlining commonalities we observe with #LMHRs, this isn't an explicit endorsement of the diet nor any altered lipid levels as a result.
With that said...
3/ We have a lot of data between our standing survey, submissions to CholesterolCode.com, and CC and LMHR Facebook groups (7.7k and 7.5k members, respectively).
Diets are often: 1) Low to no fruits & veg 2) Low to no grains 3) High animal protein 4) Low in plant oils