1/ #ReminderThread -

One thing that still surprises me is when I'm tweeting or retweeting opinion, articles, etc that are generally pro #LDL #Cholesterol-lowering or LDL-as-problematic (such as recently) I get some pushback...
2/ If you've followed me a long time, you should know this is something I'm proactive about doing -- in fact, I'm more active at doing it now than ever.

If you've only heard the ⬆️LDL isn't-so-bad case, please hear out the mainstream case on how ⬆️LDL *is* bad...
#NoEchoChambers
3/ If you somehow hadn't already heard, I literally spearheaded a crowdfunding campaign for an IRB-approved study with longitudinal CCTAs to track plaque development

Why? Because we don't know what the risk levels are for this context. If we did, there'd be no need for the study
4/ Yes, I'm interested in cholesterol levels and how they are affected by metabolic fat-adaptation, and with that specific context I'm "cautiously optimistic" with regard to risk. But is that anywhere close to "confidently certain"?

Here's a more explicit breakdown w @Lpa_Doc 👇
5/ Let me repeat that for extra emphasis, "it's certainly possible it is very dangerous" for those of us allowing for high LDL as a result of metabolic fat adaptation.

The default opinion of conventional medicine could be right and should be considered...
6/ Also worth revisiting 13/14/15 of my pinned About Me tweet.

But even better, please visit @DrNadolsky's article on The Case for Lower LDL on Low Carb here: cholesterolcode.com/guest-post-the…
7/ If I can get you to at least read one short thread I posted recently (okay, "short" for me), consider this one (7 tweets):

8/ And again, be likewise aware of #PlantBasedKeto (or at least, mostly plant-based) where wishing to be low carb, yet trying to lower LDL. (typically effective)

(Side note: I'll be doing a #FiberExperiment soon as I think fiber has a much bigger impact than previously assumed)
9/ Point is -- there's a lot that is unknown with this new context of LDL rising on a ketogenic diet, but the possibility of it being substantially causal in a rapid rise of atherosclerosis could be exactly right, and our LMHR study may provide strong evidence on this.
10/ Critics giving me pushback (whatever I'm posting) is something I'm definitely used to.

But this thread is for the supporters of my work. By this point, no one should be surprised by this -- even if I did a dozen of these kinds of tweets in a row.
11/ ... Which is kinda what this is. It's an important reminder.

If there were a Twitter competition for accounts that most re/tweet opinions and analysis counter to their own*, I'd want to be a strong contender.

(*Ideally, constructive & productive challenge, of course)

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More from @realDaveFeldman

22 Dec
1/ Yes, will comment on it in time as I have some follow up questions and comments -- but for the moment, I want to reemphasize how much I appreciate @deirdre_tobias publishing the baseline charts, making the code available, and overall devoting her time to this project...
2/ Seeing this progress and unfold over a matter of weeks is fantastic. I'm used to either getting a "sneak preview" of what an analysis might show with a given dataset or be told it will require full publication (many months and dollars down the road) in order to be public...
3/ In other words, I wish we could get this kind of turnaround and transparency on every major dataset. @deirdre_tobias has effectively done something I've been asking after for years -- and she did so at no cost.

That's worth its own distinction and one I certainly laud.
Read 4 tweets
17 Dec
1/ Yes -- if you're curious as to why @nicknorwitz and I are chatting so often about ANGPTLs, it's worth working our way backwards...

If you're powered by fat, your tissues are getting it from free fatty acids or triglycerides (which is really three FAs bundled together)...
2/ Recently I was much more focused on fasting (see ) and lipoprotein lipase (LPL) dynamics (see ) Image
3/ And indeed, the regulatory strings behind LPL up and down regulation is a much bigger part of the story with regard to VLDL turnover -- and thus potential resulting effects on LDL-C, HDL-C, and Triglycerides (TG).
Read 5 tweets
13 Dec
1/ If you want to hear a great discussion on the #LMHRstudy from my colleague,@DrNadolsky (who is most definitely pro-#LDL #Cholesterol lowering), I highly recommend this podcast that just dropped via @Plant_proof.

I'll add just a few quick thoughts...
2/ Firstly, this may be the most I've heard myself talked about in a podcast I wasn't in (😂 weird, but understandable given the context).

But while certainly critical in many respects, I felt both @DrNadolsky and @Plant_proof provided a lot of good context...
3/ @DrNadolsky bring up my oft-repeated phrase, "cautiously optimistic" [in the context of higher LDL/ApoB as a seemingly resulting from metabolic fat-adaption]

Worth repeating that mine is a hypothesis and should be treated as such, hence the "cautious" part of the phrase...
Read 8 tweets
24 Nov
1/ One of the biggest challenges in discussing these tough topics is that it can sometimes have a greater polarization effect on those listening.

I want to reiterate (as I have many times) that I strongly appreciate @ethanjweiss and our many great conversations public & private
2/ Our last conversation on @chadinabhan’s podcast certainly stirred a lot of emotion, and in that sense, it was unusual given our typical rapport.

But regardless, I have and continue to hope we can move forward with a mutual interest toward cordial conversation.
3/ As a rule, I generally avoid criticizing behavior of others given it creates a standard of perpetual policing.

That said, I’d like to ask a personal favor. I’d love if there were less personal attacks on all sides— particularly to @ethanjweiss
Read 4 tweets
21 Nov
1/ I want to take a moment to have a back-and-forth exchange with @MichaelMindrum in a thread, and I’m just gonna keep it to us (Tweet setting) I’m confident we can keep it productive. 👍

First, I think we should get on the same page with where I’m coming from..
2/ I’m not just interested in high LDL for LMHRs. I’m interested in whether it’s meaningful to distinguish high LDL from what appears to be lipid metabolic dysregulation versus high LDL in the context of metabolic fat adaptation.
3/ Much of those following this account know this already from following my work, but often critics do not.

That’s why I’d love to specificity talk to a critic I like, such as yourself, and really unpack this so we can better narrow down where the real disagreements are.
Read 9 tweets
21 Nov
1/ this one minute clip was released by @chadinabhan an hour ago, and when I watched it I got a bit concerned that it takes a clip out of context and DMed Chadi about it.

He rightly pointed out my reaction was misplaced as this was strictly a teaser.
2/ However, this did provide me an opportunity to expand on the point, given I understand where @ethanjweiss would feel this was “meaningful”.

In our exchange from several months ago (too lazy to link), Ethan pressed as to whether I’d take a statin post heart attack…
3/ I said then (and I’ll say today) – I don’t know, but I feel it would be irresponsible for me to say one way or another.

But what came up in this podcast, is it would be meaningful to Ethan if I pointed out that post MI-research I’d see a scenario where I would.
Read 6 tweets

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