Just 3️⃣simple acts of compassion can go a long way
Important RCT just published in @TheLancet shows that a family support strategy consisting of 3 extra family meetings can substantially reduce family grief 6mo after the death of a loved one in the ICU thelancet.com/journals/lance…
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Pre-pandemic, ICU mortality was often ~20%
In the US, 30-60% of ICU deaths were preceded by a decision to withdraw life support
We are experts at providing comfort focused care for patients but in many cases, families feel grief months afterwards
What can we do about this? 2/
The COSMIC RCT studied this.
The intervention was 3 family meetings held following a decision to withdraw life support:
1️⃣family conference to prepare relatives for the imminent death
2️⃣ICU-room visit to provide support
3️⃣meeting after death to offer condolences & closure
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COSMIC was done at 34 🇫🇷ICUs
Between 2017-2019, they enrolled n=484 relatives of ICU patients to the intervention group & n=391 to the control group. ICUs were cluster randomized to the 3 part intervention case SOC.
Most (78-79%) completed the 6-month telephone interview.
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The effect was pretty impressive:
The median PG-13 score (an instrument used to measure grief, not movie ratings) was lower in the intervention group: 19 vs 21
More importantly, it reduced the number of relatives with prolonged grief symptoms: 57 (15%) vs 66 (21%)
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So why tweet this? Because it will change my practice!
Pre-pandemic, I always meet with families *before* transitioning to comfort. I often informally talked to relatives afterwards. I didn’t always meet at the bedside (thinking I was giving them “space”)
COSMIC changes that.
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The combination of a large effect size (NNT 4 to prevent one person from having severe persistent grief) & being fairly easy to implement (hold two more family meetings), makes this the ideal trial to change my practice in the ICU.
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The ivermectin crazies are now recommending hydroxychloroquine too.
Their “protocol” includes a dangerously high dose of diuretics & recommends high dose steroids in people not on supplemental O2.
This has crossed the line from (mostly) harmless nonsense to actual harm.
Supporting Evidence:
A 2021 Cochrane meta-analysis (the 🥇standard) concluded that HCQ “has little or no effect on the risk of death and probably no effect on progression to mechanical ventilation. Adverse events are tripled compared to placebo…”
A more recent meta-analysis in @NatureComms that included unpublished studies went further, concluding “that treatment with hydroxychloroquine is associated with increased mortality in COVID-19 patients”
To those who are unvaccinated because of worries about “unproven mRNA technology” you know you can get:
- the J&J vaccine (🇺🇸)
- the Oxford-AZ vaccine (🇬🇧&🇪🇺)
Both can prevent hospitalization or death from COVID. Neither are mRNA vaccines. So why not get vaxxed today?
To those worried about blood clots after J&J, as of April 2021:
-there were 15 cases of TTS
-out of 8 million J&J doses
The vaccine efficacy (VE) of the J&J vaccine *is* slightly less than the mRNA alternatives: 68-71% VE to prevent hospitalization (compared to ~90% for mRNA vaccines). That’s still much much better than being Unvaxxed.
Remdesivir (RDV) is in the “We suggest no remdesivir” category.
At some level, this isn’t too surprising & is old news.
Despite initial hype, RDV never moved the needle much on patient centered outcomes (risk of mortality or requiring IMV) & many of us had stopped using it. 2/
In #ACTT1 RDV did improve outcomes on an ordinal scale, but the effect was modest. It shortened time to clinical improvement but not hospital LOS (patients stayed in the hospital longer to receive it).
RDV did NOT improve mortality or risk of IMV. ncbi.nlm.nih.gov/pubmed/32445440 3/
It’s not that it’s a spiral - one of my favorite types of graphs is the Condegram spiral. (Named after Mark Conde)
It’s used in astronomy/meteorology to show changes the Earths magnetic fields (Kp index) & is used to visualize space weather.
2/
Another awesome spiral graph - and one of the best examples of #dataviz ever IMO - is the Rose plots by Florence Nightingale.
These 1858 plots show the causes of mortality in Crimean war & make a compelling case that for improving conditions (particularly shelter in winter). 3/