Thread by @BUPRESTOStudy

New findings on #CovidVaccination and #Fertility!

Using the @BUPRESTOStudy, we show no association between #CovidVaccination in either partner and fertility among couples #TryingToConceive

A 🧵 on our new study in @AmJEpi #EpiTwitter (1/12)
doi.org/10.1093/aje/kw…

We enrolled couples who were #TryingToConceive without fertility treatment. Female and male partners completed questionnaires on lifestyle, health, and #covid19 infection and vaccination. We followed couples for up to 12 months to determine whether and when they conceived (2/12)

Then, we measured whether #TimeToPregnancy differed by vaccination status or infection history. We accounted for many factors (like occupation, income, etc.) that may be related to fertility and vaccination or infection (3/12)

For the #EpiTwitter crowd, we implemented propensity score fine stratification weighting by vaccination status to improve the validity of our results – unweighted and weighted models yielded similar results (4/12)

We found that #CovidVaccination in either partner was unrelated to fertility, regardless of time since vaccination or vaccine brand (5/12)

On the other hand, men who recently had #COVID19 infection had a short-term decline in fertility for ~2 months (6/12)

Given what we know about the adverse effects of getting #COVID19 during #pregnancy on maternal and perinatal health, #CovidVaccination during the #preconception period is important (7/12)

But what about concerns that #CovidVaccination influences #MenstrualCycles?

@NICHD_NIH funded 5 studies to look at this (including ours!). New paper from @greenjrnl shows some small, short-term changes in cycle length after vax... (8/12)

But our results here indicate that even if these changes are happening, there are no subsequent effects on fertility. (9/12)

This paper adds to the growing literature showing that #CovidVaccination does not cause #infertility (10/12)

This project took a village. Big thanks to authors @AKWesselink @ken_rothman @marydotwillis @HollyMCrowe @JenniferYland @RuthJGeller @SydneyWillis9 @AnnetteKRegan @LaurenAnneWise @dceaarhus @BUSPH, funders @NICHD_NIH, and @BUPRESTOStudy participants (11/12)

PRESTO is ongoing, and we are currently enrolling participants from all over the U.S. and Canada. If you want to learn more about @BUPRESTOStudy, check out our website:
presto.bu.edu (12/12)